Primary Care

Latest AI and machine learning research in primary care for healthcare professionals.

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Advancing continuous in-situ quantification of microbial contamination in environmental waters using tryptophan-like fluorescence-Sensor design and validation.

Microbial contamination of recreational and source waters poses persistent public health risks, yet conventional monitoring based on laboratory culture methods provides delayed results and limited temporal resolution. These constraints hinder timely identification of short-duration contamination events and effective management of recreation advisories. This study evaluates the performance of a con...

May 15 2026 42156217

Crash root-cause identification via trace-rewarded causation chain reasoning large language model.

Road traffic crash is one of the top leading causes of death worldwide. To support the deployment of modern safety improvements such as Highly Automated Driving (HAD), collision analysis requires to reveal crash formation and find the root-causes. This study explores Large Language Model (LLM)-based techniques to reconstruct the crash causation chain, and reveal the root-causes underlying crash oc...

May 15 2026 42140126
Unveiling the gap in heart failure: a Brazilian Unified Health System study.

BACKGROUND: Heart failure (HF) decompensation is the leading cause of hospitalisations in developed countries and the third most common cause in Brazi...

May 15 2026 42138265
Obesity, microRNA circulating microRNA signatures reveal core and reversible dysregulations in obesity via machine learning.

Obesity is a complex metabolic disease characterized by systemic metabolic and inflammatory dysregulation, yet the molecular signatures underlying the...

May 15 2026 42139044
Complication Risk Classification in Children and Adolescents With Type 1 Diabetes: Interpretable Machine Learning Study Based on Saudi Clinical Guidelines.

BACKGROUND: Complication risks in children and adolescents with type 1 diabetes (T1D) can lead to serious health outcomes if not detected early. Despi...

May 15 2026 42139456
Using Digital Phenotyping for Depression Screening in Community-Dwelling Older Adults: Bayesian Multilevel Hurdle Model Machine Learning Approach.

BACKGROUND: With the rapidly aging population, mental health among older adults has received growing attention. Although the likelihood of experiencin...

May 15 2026 42139722
Clinical setting-dependent diagnostic accuracy of artificial intelligence and store-and-forward diabetic retinopathy screening: a systematic review and meta-analysis.

Population-based diabetic retinopathy (DR) screening requires diagnostic strategies that optimize clinical utility by balancing missed disease against...

May 15 2026 42141103
Leveraging artificial intelligence to predict non-adherence to pediatric immunization schedules: a systematic review.

UNLABELLED: Immunization is one of the most effective interventions to prevent infectious diseases. Identifying individuals at risk of non-adherence t...

May 15 2026 42141249
Interpretable machine learning model integrating MRI-derived paraspinal muscle parameters for predicting new vertebral compression fractures after vertebral augmentation.

OBJECTIVES: To develop and validate interpretable machine learning (ML) models incorporating MRI-derived paraspinal muscle parameters to predict new v...

May 15 2026 42141290
Development and validation of an explainable machine learning model using routine laboratory biomarkers for identifying prevalent MASLD: Evidence from two observational studies.

Although many predictive models for metabolic dysfunction-associated steatotic liver disease (MASLD) have been developed, their performance remains su...

May 15 2026 42141301
Noninvasive early detection and grading of pneumoconiosis via plasma proteomics and machine learning: PRSS3 as a potential biomarker.

BACKGROUND: Coal-dust, a persistent airborne pollutant, induces dose-related pulmonary fibrosis; however, plasma biomarkers for pre-clinical toxicity ...

May 15 2026 42141418
Construction of a predictive model for the risk of non-alcoholic fatty liver disease in patients with sleep apnea syndrome based on multiple machine learning algorithms: a multicenter study.

BACKGROUND: Sleep apnea syndrome (SAS) is closely related to an increased risk of non-alcoholic fatty liver disease (NAFLD), but current clinical tool...

May 15 2026 42141448
Co-application of pan-genomics and machine learning uncovers novel insights into the maintenance and evolution of microcystins production trait in Microcystis.

Microcystins (MCs), the potent hepatotoxins produced by toxic strains of Microcystis and other cyanobacteria, pose a major threat to freshwater ecosys...

May 14 2026 42595398
Beyond eGFR and Albuminuria: Biological Pathways and Multiomics in Cardiovascular-Kidney-Metabolic Disease.

Cardiovascular-kidney-metabolic disease (CKM) represents a growing public health challenge driven by the convergence of obesity, diabetes, and cardiov...

May 14 2026 42290908
PL-PatchSurfer3: improved structure-based virtual screening for structure variation using 3D Zernike descriptors.

Structure-based virtual screening (SBVS) is a widely used approach in in silico drug discovery, requiring a receptor structure or binding site to pred...

May 14 2026 42135840
Phenotyping Preeclampsia Using Unsupervised Machine Learning: A Prospective Cohort Study.

OBJECTIVE: To explore clinically meaningful phenotypes of preeclampsia using unsupervised machine learning. DESIGN: Prospective cohort study. SETTING:...

May 14 2026 42136148
Editorial Commentary: Traveling to A New Dimension in Anterior Cruciate Ligament Injury Risk Stratification: Holistic 3-Dimensional Knee Phenotyping via Automated Artificial Intelligence Pipelines.

Morphologic risk stratification for anterior cruciate ligament injury has historically relied upon isolated two-dimensional radiographic parameters (e...

May 14 2026 42136217
Global Trends and Research Hotspots in Soccer Injury Literature: A Bibliometric Analysis (1904-2025).

IMPORTANCE: Soccer is associated with a substantial global injury burden, particularly involving lower-extremity and head injuries. Despite extensive ...

May 14 2026 42140438
Performance and Utility of the Sybil Deep Learning Model for Lung Cancer Risk Prediction in Asian High- and Low-Risk Populations.

BACKGROUND: Sybil is a deep learning model designed to predict future lung cancer risk based on a single low-dose chest CT (LDCT) scan, facilitating a...

May 14 2026 42140481
Plasma extracellular vesicle proteins biomarker for cerebral small vessel disease related cognitive impairment.

BACKGROUND: Cerebral small vessel disease (CSVD) is a major contributor to vascular dementia. Given the absence of effective treatments, the developme...

May 14 2026 42129839
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