Latest AI and machine learning research in primary care for healthcare professionals.
The retinoblastoma (RB1) gene is a critical tumor suppressor that regulates cell cycle progression and genomic stability. Although RB1 alterations have been reported in hepatocellular carcinoma (HCC), the biological and clinical consequences of biallelic RB1 inactivation (RB1-Bi) remain poorly defined. We performed a comprehensive allele-specific genomic analysis of HCC patients from the TCGA-LIHC...
Pesticide residues with diverse toxicities and synergistic effects demand rapid, multiplexed discrimination methods beyond conventional single-analyte assays. Here, we report a machine-learning-enhanced three-channel colorimetric sensor array based on Cu-Pt bimetallic nanozymes for multi-class pesticide fingerprint recognition. The single CuPtBN receptor integrates oxidase-, laccase-, and superoxi...
BACKGROUND: Mental health apps are frequently used as platforms for delivering digital health interventions to young people. New technology such as ge...
Robot-assisted vascular intervention may reduce occupational radiation exposure, improve procedural stability, and expand access to specialized endova...
IMPORTANCE: Basal cell carcinoma (BCC) is the most common type of skin cancer worldwide. Particularly on the face, its locally destructive growth lead...
The Cardiovascular-Kidney-Metabolic (CKM) syndrome reframes cardiovascular, kidney, and metabolic disease as an integrated continuum, yet its manageme...
BACKGROUND: Screening for atherosclerosis is essential for early intervention, but conventional screening methods are often invasive and resource-inte...
Diabetic encephalopathy (DE) is a serious complication of diabetes mellitus characterized by progressive cognitive dysfunction; but its underlying mec...
OBJECTIVE: Adiposity rebound (AR), the second rise in BMI during growth, increases the risk of obesity and metabolic diseases when it occurs early. We...
AIM: To investigate whether artificial intelligence (AI) models trained on standard 12-lead electrocardiograms (ECG) can identify symptom-defined diab...
Artificial intelligence (AI) is transforming healthcare delivery globally, with increasing applications in public health dentistry. This scoping revie...
BACKGROUND: With growing prevalence of mild cognitive impairment and dementia, online self-administered pre-screening tests hold the promise to more o...
Although preventable oral diseases are still very common among school-aged children worldwide, dental caries remains a significant public health conce...
Traditional research ethics governance was designed for bounded protocols, identifiable investigators, and temporally limited encounters with human pa...
Diabetes represents a significant global health challenge, underscoring the need for enhanced methodologies in glycemic monitoring and risk assessment...
Interval breast cancers are diagnosed between screening rounds. Because they portend a worse diagnosis than screen-detected cancers, decreasing the in...
BACKGROUND: Advanced HIV disease remains a major global health concern, with nearly 40.8 million people living with HIV as of 2024. Antiretroviral the...
BACKGROUND: Automated multimedia analysis of remotely recorded tasks offers a scalable approach to screening and remote monitoring of movement disorde...
OBJECTIVE: To systematically compare the differences in urinary organic acid metabolic profiles between patients with urinary calculi and non-calculi ...
Red blood cell (RBC) transfusion is a core clinical intervention. However, hypothermic storage induces progressive biochemical, structural, and functi...