Primary Care

An interpretable machine learning model for predicting stroke in patients with hypertension: insights from the SPRINT.

Stroke is a leading cause of mortality worldwide, with hypertension being its most significant risk ...

Adapting the REVEAL Lite 2 score to the pediatric population through machine learning: insights from the REHIPED registry for pediatric pulmonary hypertension.

INTRODUCTION AND OBJECTIVES: Risk scores for pulmonary hypertension (PH) have been proven useful in ...

Optimizing Timeliness of Healthcare Delivery in Diagnostic Radiology at U.S. Academic Centers.

RATIONALE AND OBJECTIVES: Timely radiology access is essential for accurate diagnosis, treatment pla...

Empowering Patients and Clinicians: LLMs in Hypertension Care: A Scoping Review.

Large language models have emerged as potential tools to support hypertension care, including diagno...

Machine Learning Analysis of Serum Metabolomics for Multi-Disease Classification and Proteome-Metabolome Pathway Insights in T2D, IBD, and CRC.

Type 2 diabetes (T2D), inflammatory bowel disease (IBD), and colorectal cancer (CRC) share overlappi...

A structure-based virtual screening approach to identify novel anaplastic lymphoma kinase inhibitors.

CONTEXT: Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that plays a crucial role in...

Unsupervised Agglomerative Cluster Phenotyping of Young Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention.

BACKGROUND: Young patients with acute coronary syndrome (ACS) exhibit diverse demographic, clinical ...

Screening of metabolic-related biomarkers linking intervertebral disc degeneration and type 2 diabetes based on comprehensive bioinformatics analysis and machine learning.

BACKGROUND: Intervertebral disc degeneration (IVDD) is a prominent etiology of lower back pain. Type...

Precision nutrition in breast cancer: Towards patient- and tumour-informed dietary strategies.

Dietary strategies are increasingly recognized as important modulators of breast cancer outcomes, ac...

Monitoring airline pilot mental health: a 3PM framework utilising digital phenotyping and AI.

The aeromedical certification of commercial airline pilots relies on periodic, self-disclosure-depen...

Comparative evaluation of obesity-related indices for predicting incident hypertension: evidence from Chinese and UK longitudinal cohorts with machine learning interpretation.

Modelling the epidemic dynamics of HPV among women in China and optimization of ongoing cervical cancer elimination strategies.

BACKGROUND: The infection of high-risk human papillomavirus (hr-HPV) and related cervical cancer hav...

Association of epigenetic trajectory with development of clinical rheumatoid arthritis in anti-citrullinated protein antibody positive individuals: Targeting Immune Responses for Prevention of Rheumatoid Arthritis (TIP-RA).

OBJECTIVE: The presence of anti-citrullinated protein antibodies (ACPAs) in the absence of clinical ...

Urinary Proteomics: Biological Foundations, Analytical Frameworks, and Clinical Translation Across Human Diseases.

Urinary proteomics has swiftly emerged as a formidable tool for the identification of non-invasive b...

Detection of young-onset type 2 diabetes using deep learning across primary and secondary care: a nationwide, retrospective cohort study.

BACKGROUND: Once considered a disease observed in older adults, type 2 diabetes is now increasingly ...

Macrocyclic peptides as protein-protein interaction modulators: a review.

Protein-protein interactions (PPIs) govern essential cellular processes, such as signal transduction...

Urinary extracellular vesicle miRNA signature reflects pancreatic islet stress in type 2 diabetes.

INTRODUCTION: Type 2 diabetes (T2D) is a progressive metabolic disorder characterized by insulin res...

FOSL2 regulates endothelial cell state and chromatin accessibility in systemic sclerosis pulmonary vascular remodeling.

Systemic sclerosis (SSc) is characterized by fibrosis and vasculopathy affecting the skin and intern...

Precision biomarker discovery in hypertension through explainable AI and proteomics.

Hypertension is a major global health burden and a leading driver of cardiovascular disease, yet rel...

A Multicenter Prospective Study to Develop a Prediction Model for Postherpetic Neuralgia Using Clinical and Laboratory Indicators.

INTRODUCTION: Postherpetic neuralgia (PHN) is the most common and difficult-to-treat complication of...

Comparative study on the predictive value of PNI and GNRI for all-cause mortality rates of elderly patients in cardiac care unit and cardiovascular intensive care unit.

BACKGROUND: The prognostic nutritional index (PNI) and geriatric nutritional risk index (GNRI) are r...