Primary Care

Latest AI and machine learning research in primary care for healthcare professionals.

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Environmental toxicant exposure and diabetes risk: An exposome-wide association study integrating mixture effects and molecular mechanisms.

Environmental toxicant exposure has emerged as a potential contributor to diabetes, yet systematic investigations integrating multiple chemicals and biological mechanisms remain limited. This study employed a hypothesis-generating, exposome-toxicogenomic framework to examine the associations between diverse environmental toxicants and diabetes risk and to explore underlying biological pathways. Da...

Feb 23 2026 41734627

Machine Learning Integration of MRI Intratumoral and Peritumoral Radiomics Features for Predicting PNSTs Postoperative Complications.

RATIONALE AND OBJECTIVES: Postoperative complications (15-76%) substantially affect patients with peripheral nerve sheath tumors (PNSTs), yet objective preoperative risk tools are lacking. Magnetic resonance imaging (MRI) radiomics has focused mainly on intratumoral regions, while the predictive value of the peritumoral microenvironment remains unclear. MATERIALS AND METHODS: In this retrospective...

Feb 23 2026 41735109
The Predictive Value of Machine Learning for Postoperative Delirium in Cardiac Surgery: Systematic Review and Meta-Analysis.

BACKGROUND: Postoperative delirium (POD) following cardiac surgery is a severe complication, and early identification of delirium risk remains a chall...

Feb 23 2026 41730167
AI-Driven Patient Screening for Clinical Trials in Pancreatic Cancer: The PANCR-AI Pilot Retrospective Comparative Study.

BACKGROUND: Screening for clinical trials is challenging for clinicians due to its time-consuming and repetitive nature. The rise of artificial intell...

Feb 23 2026 41730173
Cardiorespiratory Markers of Type 2 Diabetes: Machine Learning-Based Analysis.

BACKGROUND: The global prevalence of type 2 diabetes mellitus (T2DM) poses significant challenges due to its association with increased cardiovascular...

Feb 23 2026 41730180
Artificial Intelligence-Enabled ECG Analysis to Predict Incident Heart Failure.

BACKGROUND: ECG-based artificial intelligence may enable efficient prediction of incident heart failure (HF) risk to facilitate preventive efforts. Pr...

Feb 23 2026 41730522
Multivariate feature analysis of early-stage laryngeal cancer serum components using surface-enhanced Raman spectroscopy.

Laryngeal cancer is a common head-and-neck malignant tumor with geographically variable incidence. Its lack of specific early clinical symptoms often ...

Feb 21 2026 41740394
Efficient self-supervised Barlow Twins from limited tissue slide cohorts for colonic pathology diagnostics.

Colorectal cancer (CRC) is one of the few cancers that have an established dysplasia-carcinoma sequence that benefits from screening. Everyone over 50...

Feb 21 2026 41793844
Multicentre development and validation of a risk model integrating immunotherapy and coagulation biomarkers for thrombosis in autoimmune neurological disorders.

PURPOSE: Patients with Autoimmune Neurological Disorders (ANDs) require routine immunomodulatory therapy, which inherently increases thrombosis risk. ...

Feb 21 2026 41723895
Subtypes of newly diagnosed type 2 diabetes and risk of complications: analysis of electronic health records in the USA.

AIMS/HYPOTHESIS: Data-driven subtyping of type 2 diabetes has not been translated into clinical practice due to the lack of routine fasting glucose an...

Feb 21 2026 41723302
Machine learning-based prediction of persistent diabetic macular edema using OCT-derived structural biomarkers and clinical features.

BACKGROUND: Persistent diabetic macular edema (DME) remains a leading cause of vision loss in diabetic retinopathy, even with anti-VEGF therapy. About...

Feb 21 2026 41723562
Machine learning-assisted abstract screening on learning analytics: a step-by-step tutorial.

Systematic reviews are crucial for synthesizing evidence, but their manual processes, particularly abstract screening, are labor-intensive and prone t...

Feb 21 2026 41721428
Multidimensional analysis of postoperative nursing challenges in oral cancer surgery: a retrospective study of 245 patients and proposal of the PROTECT mode.

PURPOSE: The quality of postoperative care for oral tumors critically influences patient prognosis and quality of life; however, current nursing syste...

Feb 20 2026 41718893
Probiotic therapeutics: A critical review of mechanisms, clinical efficacy, and the frontier of precision microbiome modulation.

Probiotic therapeutics are evolving from generalized wellness supplements to precision Live Biotherapeutic Products aimed at specific disease targets....

Feb 20 2026 41722541
Inadequate Preventive Dental Care Is Associated With Higher Cardiovascular Risk Identified by ECG-Based Artificial Intelligence Algorithms.

BACKGROUND: Inadequate preventive dental care may contribute to inflammatory conditions such as periodontitis, increasing cardiovascular disease risk....

Feb 20 2026 41717947
Integrated Human Organic Pollutant Exposome and Metabolome Analysis Reveals Biomarkers and Health Risks from Electronic Waste Exposure.

Escalating global electronic waste (e-waste) generation contrasts with <20% formal recycling rates. Policy gaps and inadequate enforcement exacerbate ...

Feb 20 2026 41718006
Co-Designed Mental Health Screening App (Here for You) for University Students: Pilot Feasibility Mixed Methods Study.

BACKGROUND: Mental health disorders are a growing public health concern among university students globally and in India, exacerbated by stigma and lim...

Feb 20 2026 41719540
Ensemble Machine Learning Models for Predicting Patients With High Usage: Model Validation and Economic Impact Analysis.

BACKGROUND: Machine learning models are increasingly used to predict patients at risk of high health care usage for targeted interventions. OBJECTIVE:...

Feb 20 2026 41719547
Assessment of GFR Estimation Methods in Patients With Obesity.

CONTEXT: Obesity is an independent risk factor for chronic kidney disease, and accurate estimation of the glomerular filtration rate (GFR) is crucial....

Feb 20 2026 40930519
Prediction of COVID-19 hospitalisation, ICU admission or death following ChAdOx1 vaccination using artificial intelligence: A clinical predictive model from the English RAVEN study.

OBJECTIVES: This study identifies predictors of severe COVID-19 following completion of two-dose primary series of the AZD1222 COVID-19 vaccine, emplo...

Feb 20 2026 41719246
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