Primary Care

Latest AI and machine learning research in primary care for healthcare professionals.

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Aortic and Cardiac Structure From Routine CT Predict Cardiovascular Risk Beyond PREVENT and Coronary Calcium.

BACKGROUND: Cardiovascular disease prevention relies on accurate risk assessment; however, existing scores are imprecise. Routine imaging may be opportunistically used to predict risk. OBJECTIVES: The authors tested whether computed tomography (CT)-derived cardiac and aortic structure predicts major adverse cardiac events (MACE) beyond standard-of-care scores. METHODS: The authors developed a leas...

Feb 19 2026 41718510

Non-invasive screening for ovarian cancer by combining serum SERS with interpretable machine learning models.

Early identification of malignant ovarian tumors is critical for informing treatment decisions and enhancing patients' quality of life. As the third most prevalent gynecologic cancer globally, ovarian cancer remains challenging to diagnose due to the high cost, limited accessibility, and radiation exposure associated with current screening techniques. This study integrates surface-enhanced Raman s...

Feb 19 2026 41724105
AI-driven CRISPR screening: optimizing gene editing through automation and intelligent decision support.

BACKGROUND: CRISPR-based genetic screening has become a central methodology in functional genomics, enabling systematic interrogation of gene function...

Feb 19 2026 41715150
Mapping the integration of artificial intelligence and digital technologies in health technology assessment: a scoping review protocol of global knowledge and practices.

BACKGROUND: Health Technology Assessment (HTA) is a cornerstone of evidence for informing health policy and resource allocation globally. Rapid advanc...

Feb 19 2026 41715226
The future of periodontology: Emerging technologies and conceptual shifts.

Periodontology is entering a transformative era driven by advances in diagnostics, therapeutics, and digital integration. Emerging technologies and co...

Feb 19 2026 41711187
Healthcare applications of 0-1 neural networks in prescriptive problems with observational data.

A key challenge in medical decision making is learning treatment policies for patients with limited observational data. This challenge is particularly...

Feb 19 2026 41712078
Smart Kiosk for Nutritional Management of People With Diabetes in Underserved Communities: Development and Technical Evaluation.

BACKGROUND: Diabetes is a chronic disease with a high global prevalence, increasing from 200 million people in 1990 to 830 million in 2022, with a hig...

Feb 19 2026 41712775
Screening for Clinically Significant Nephrolithiasis Based on Simple Health Checkup Clinical and Urine Parameters in General Populations: Multicenter Machine Learning Study.

BACKGROUND: Nephrolithiasis affects approximately 15% of the population and often remains undetected in asymptomatic individuals. Current diagnostic a...

Feb 19 2026 41712857
Analysis of Associated Factors and Construction of Risk Prediction Models for Frailty in Hospitalized Older Adults Living With HIV: Protocol for a Prospective Observational Study.

BACKGROUND: The aging trend of people living with HIV or AIDS in China is increasing day by day. Frailty is a common condition among older adults livi...

Feb 19 2026 41712913
Securing Federated Learning With Blockchain in the Medical Field: Systematic Literature Review.

BACKGROUND: The exponential growth of medical data and advancements in artificial intelligence (AI) have accelerated the development of data-driven he...

Feb 19 2026 41712960
Finding the forest in the trees: Using machine learning and online cognitive and perceptual measures to predict adult autism diagnosis.

Traditional subjective measures are limited in the insight they provide into underlying behavioral differences associated with autism and, accordingly...

Feb 19 2026 41714590
Bulk and single-cell transcriptomics for identification of potential diagnostic biomarkers associated with pulmonary arterial hypertension and integrated stress response and experimental validation.

BACKGROUND: Pulmonary arterial hypertension (PAH) is a lethal vascular disorder characterized by irreversible remodeling of the pulmonary arteries, bu...

Feb 18 2026 41706425
Integrating machine learning and SHAP analysis to identify the risk of cognitive frailty in older adults with chronic heart failure.

BACKGROUND: Accurately identifying older adults with chronic heart failure (CHF) at high risk of cognitive frailty is crucial for timely preventive in...

Feb 18 2026 41886834
Novel Systemic Associations of Idiopathic Epiretinal Membrane Identified via Machine Learning.

PURPOSE: To discover novel systemic associations that may lead to idiopathic epiretinal membrane (iERM) using interpretable machine learning models. D...

Feb 18 2026 41908500
Landmark-based deep learning for radiographic screening for developmental dysplasia of the hip in infants: Development and external evaluation with IHDI-guided triage.

BACKGROUND: In Japan, secondary screening for developmental hip dysplasia has expanded. However, the capacity of screening programs has outpaced the a...

Feb 18 2026 41714232
Hepatic and abdominal adiposity in type 2 diabetes as assessed with machine learning on computed tomography scans.

AIMS: The combined assessment of multiple abdominal imaging traits in relation to type 2 diabetes remains incompletely characterised. The study examin...

Feb 18 2026 41705581
A machine learning approach to predicting severe diabetes distress in adults with type 1 diabetes mellitus.

BACKGROUND: Diabetes distress is common in patients with type 1 diabetes mellitus (T1DM). The aim of this study was to construct and validate predicti...

Feb 18 2026 41705740
Artificial intelligence enhances screening efficiency for inflammatory bowel disease clinical trials: a prospective study.

An LLM-based AI tool significantly improved identification of potentially eligible patients and screening efficiency for IBD clinical trials, outperfo...

Feb 18 2026 41706015
Vulnerability and short clinical outcomes in patients on the deceased-donor kidney transplant waiting list.

BACKGROUND: With prolonged waiting times for deceased-donor kidney transplantation (DDKT) in Japan, objective data on frailty among wait-listed patien...

Feb 18 2026 41706301
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