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Electrocardiogram Abnormality Classification From Summary Statistics With Patient-Level Validation and Process-Focused Evaluation.

BACKGROUND: Machine learning (ML) applications in clinical medicine are vulnerable to data leakage, particularly temporal leakage from post-diagnostic features and patient-level leakage from improper partitioning, compromising electrocardiogram (ECG) abnormality detection systems. This study addresses these vulnerabilities through patient-level data splitting and systematic evaluation across multi...

Sep 1 2026 42578331

Large Language Models as Clinical Support Tools in Drug Information Services: Performance Comparison With Pharmacists.

BACKGROUND: Large language models (LLMs) are increasingly explored for drug information support, yet their reliability and clinical applicability remain uncertain. This study evaluated multiple LLMs in responding to real-world drug information questions retrieved from a university hospital in Thailand, focusing on clarity in Thai, concordance with pharmacist responses, relevance, context awareness...

Sep 1 2026 42591004
Deep learning auto-contouring of target and organs-at-risk on post-catheter implant CT images for prostate HDR brachytherapy.

BACKGROUND: Accurate delineation of the prostate and surrounding organs-at-risk (OARs) is essential for HDR prostate brachytherapy. Manual contouring ...

Sep 1 2026 42613795
QwenCryoMarker: a universal post-processing framework for contamination-aware particle cleaning.

Cryo-electron microscopy (cryo-EM) micrographs are frequently contaminated by carbon edges, ice crystals, ethane bubbles and other high-contrast artif...

Sep 1 2026 42621759
Artificial intelligence in prior authorization and coverage decisions: A systematic review of methods, evidence gaps, and future implications for patient access.

BACKGROUND: Prior authorization (PA) is intended to support appropriate use and spending of services and medications, yet 1 in 6 insured adults report...

Sep 1 2026 42640127
Multisite Implementation of a Digital Wound Model of Care: A Post-Implementation Multimethods Evaluation of Patient and Clinician Perspectives and Lessons Learned.

This study evaluated district-wide implementation of a digital wound model of care combining an artificial intelligence-enabled application with a vir...

Sep 1 2026 42660862
Unsupervised Ensemble Learning for Active Drug-Induced Liver Injury Surveillance: Integrating Pharmacokinetic Burden With Enzyme Trajectories.

PURPOSE: Traditional drug-induced liver injury (DILI) surveillance relying on static laboratory thresholds frequently misses early kinetic evolution. ...

Sep 1 2026 42666122
The Digital Transformation of Rehabilitation Medicine: A Narrative Review of Artificial Intelligence Innovations, Clinical Integration, and Future Paradigms.

BACKGROUND: Traditional rehabilitation medicine, primarily dependent on qualitative clinical assessment and static therapeutic protocols, faces signif...

Sep 1 2026 42671200
Detecting short-term post-traumatic stress disorder symptom increases among veterans: machine-learning analysis integrating wearable sensor and daily self-report data.

BACKGROUND: Post-traumatic stress disorder (PTSD) symptoms can fluctuate substantially over short periods, yet routine screening typically relies on i...

Sep 1 2026 42676155
Predicting Call Abandonment in a Health Care Call Center Using Nonpersonal Operational Data: Machine Learning Study.

BACKGROUND: Call abandonment is a critical barrier to patient access in health care call centers; yet, predictive modeling efforts are limited by stri...

Aug 31 2026 42673578
The Role of Artificial Intelligence Models in Predicting Post-Prosthetic Facial Esthetics in Edentulous Patients: Clinical and Anthropometric Comparative Study.

OBJECTIVES: Artificial intelligence (AI) is increasingly used in esthetic dentistry; however, its accuracy in predicting post-prosthetic facial outcom...

Aug 29 2026 42667931
Development of a machine-learning risk stratification tool for vasoactive medication need after two-bolus fluid resuscitation in pediatric suspected sepsis.

BACKGROUND: Timely vasopressor initiation is critical in fluid-refractory pediatric septic shock, yet clinicians lack objective tools to identify chil...

Aug 29 2026 42668278
Development and validation of a machine learning-based model for predicting fall-related injury risk in hospitalized patients.

BACKGROUND: Falls are among the most common adverse events in hospitalized patients, with about 30% leading to injury. We developed a machine learning...

Aug 28 2026 42664072
ERP-XTTN: interpretable prototype-guided cross-attention for cross-subject ERP classification.

OBJECTIVE: Interpretable brain-computer interface classifiers that generalize across subjects without calibration remain an open challenge. We evaluat...

Aug 27 2026 42660175
Stigmatizing Language in Gender-Expansive Patient Records: Corpus Development, Disparity Analysis, and Natural Language Processing-Based Detection Study.

BACKGROUND: Stigmatizing language (SL) in electronic health records (EHRs) can influence clinical decision-making, propagate bias across care encounte...

Aug 27 2026 42660538
Clinician-led, AI-assisted clinical software development: multi-domain verification of a deployed ePROM application.

BACKGROUND: Generative AI lowers the technical barrier to clinician-led software development, but functional success and usability do not establish cl...

Aug 27 2026 42664732
CLIN-LLM: A safety-constrained hybrid framework for clinical diagnosis and treatment generation.

Accurate symptom-to-disease classification and clinically-grounded treatment recommendations remain challenging, particularly in heterogeneous patient...

Aug 27 2026 42658861
Deciphering Post-surgery Gut Microbial Dynamics in Colorectal Cancer through Multi-cohort Machine Learning.

Surgical resection, and its associated bowel preparation, remain the primary treatment for colorectal cancer (CRC), yet the associated effects on post...

Aug 26 2026 42645508
Artificial Intelligence in Pharmacovigilance: Guiding Principles from the CIOMS Working Group XIV.

Artificial intelligence (AI) is increasingly being explored to support pharmacovigilance activities including processes involving individual case safe...

Aug 26 2026 42645766
Multichamber Myocardial Strain for Cardiovascular Risk Stratification in Liver Transplant Recipients Using Interpretable Machine Learning.

BACKGROUND: Cardiovascular events are a leading cause of mortality after liver transplantation (LT), and existing risk scores incompletely capture myo...

Aug 26 2026 42648277
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