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Emerging trends in post-translational modification: Shedding light on Glioblastoma multiforme.

Recent multi-omics studies, including proteomics, transcriptomics, genomics, and metabolomics have revealed the critical role of post-translational modifications (PTMs) in the progression and pathogenesis of Glioblastoma multiforme (GBM). Further, PTMs alter the oncogenic signaling events and offer a novel avenue in GBM therapeutics research through PTM enzymes as potential biomarkers for drug tar...

Oct 18 2023 37858622

Polygenic modelling and machine learning approaches in pharmacogenomics: Importance in downstream analysis of genome-wide association study data.

Genome-wide association studies (GWAS) have identified genetic variations associated with adverse drug effects in pharmacogenomics (PGx) research. However, interpreting the biological implications of these associations remains a challenge. This review highlights 2 promising post-GWAS methods for PGx. First, we discuss the polygenic architecture of the PGx traits, especially for drug-induced liver ...

Oct 11 2023 37743713
Inherently interpretable position-aware convolutional motif kernel networks for biological sequencing data.

Artificial neural networks show promising performance in detecting correlations within data that are associated with specific outcomes. However, the b...

Oct 11 2023 37821530
Multi-omics integration strategy in the post-mortem interval of forensic science.

Estimates of post-mortem interval (PMI), which often serve as pivotal evidence in forensic contexts, are fundamentally based on assessments of variabi...

Sep 29 2023 37839320
The Effect of Using a Rehabilitation Robot for Patients with Post-Coronavirus Disease (COVID-19) Fatigue Syndrome.

The aim of this study was to compare the effectiveness of traditional neurological rehabilitation and neurological rehabilitation combined with a reha...

Sep 27 2023 37836950
Comparison of post reconstruction- and reconstruction-based deep learning denoising methods in cardiac SPECT.

. The quality of myocardial perfusion SPECT (MPS) images is often hampered by low count statistics. Poor image quality might hinder reporting the stud...

Sep 13 2023 37666231
Determinants of Attitude to a Humanoid Social Robot in Care for Older Adults: A Post-Interaction Study.

BACKGROUND While there is a growing body of research examining opinions on social robots in elderly care, there is a lack of comprehensive studies inv...

Sep 8 2023 37679949
Identifying the serious clinical outcomes of adverse reactions to drugs by a multi-task deep learning framework.

Adverse Drug Reactions (ADRs) have a direct impact on human health. As continuous pharmacovigilance and drug monitoring prove to be costly and time-co...

Aug 24 2023 37620651
pBRICS: A Novel Fragmentation Method for Explainable Property Prediction of Drug-Like Small Molecules.

Generative artificial intelligence algorithms have shown to be successful in exploring large chemical spaces and designing novel and diverse molecules...

Aug 16 2023 37585609
Will artificial intelligence chatbots replace clinical pharmacologists? An exploratory study in clinical practice.

PURPOSE: Recently, there has been a growing interest in using ChatGPT for various applications in Medicine. We evaluated the interest of OpenAI chatbo...

Aug 11 2023 37566133
Post-Processing Fairness Evaluation of Federated Models: An Unsupervised Approach in Healthcare.

Modern Healthcare cyberphysical systems have begun to rely more and more on distributed AI leveraging the power of Federated Learning (FL). Its abilit...

Aug 9 2023 37097792
Domain Agnostic Post-Processing for QRS Detection Using Recurrent Neural Network.

Deep-learning-based QRS-detection algorithms often require essential post-processing to refine the output prediction-stream for R-peak localisation. T...

Aug 7 2023 37018588
Enhancing the prediction of IDC breast cancer staging from gene expression profiles using hybrid feature selection methods and deep learning architecture.

Prediction of the stage of cancer plays an important role in planning the course of treatment and has been largely reliant on imaging tools which do n...

Aug 2 2023 37530887
Teeth Lesion Detection Using Deep Learning and the Internet of Things Post-COVID-19.

With a view of the post-COVID-19 world and probable future pandemics, this paper presents an Internet of Things (IoT)-based automated healthcare diagn...

Jul 31 2023 37571620
Post-chemotherapy robot-assisted retroperitoneal lymph node dissection for metastatic germ cell tumors: safety and perioperative outcomes.

PURPOSE: To evaluate the feasibility, safety, and early oncologic outcomes after post-chemotherapy robot-assisted retroperitoneal lymph node dissectio...

Jul 28 2023 37507528
Initial Testing of Robotic Exoskeleton Hand Device for Stroke Rehabilitation.

The preliminary test results of a novel robotic hand rehabilitation device aimed at treatment for the loss of motor abilities in the fingers and thumb...

Jul 12 2023 37514633
Will the future of pharmacovigilance be more automated?

INTRODUCTION: Artificial intelligence (AI) based tools offer new opportunities for pharmacovigilance (PV) activities. Nevertheless, their contribution...

Jul 12 2023 37435796
Home-based upper limb stroke rehabilitation mechatronics: challenges and opportunities.

Interest in home-based stroke rehabilitation mechatronics, which includes both robots and sensor mechanisms, has increased over the past 12 years. The...

Jul 9 2023 37424017
Implementation of totally robotic right hemicolectomy: lessons learned from a prospective cohort.

Robotics facilitates the realization of intra-corporeal anastomosis during right hemicolectomy and allows extracting the operative specimen through a ...

Jun 21 2023 37341877
Harnessing artificial intelligence in the post-COVID-19 era: A global health imperative.

Despite the World Health Organization's declaration that the COVID-19 global emergency has ended, the threat of future pandemics remains a significant...

Jun 20 2023 37340738
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