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Permutation-calibrated stability discovery under ???? >> ????: A leak-controlled Machine Learning framework identifies candidate proteomics panels in antiseizure medication-related side effects

We investigated whether the plasma proteome distinguishes people with epilepsy who report central nervous system (CNS) side effects from antiseizure medications (ASMs) from those who do not. In 161 patients profiled using proximity extension assay-based proteomics Neurology and Inflammation panels (~1,447 proteins), we applied an ensemble leak-controlled machine-learning (ML) workflow based on LAS...

Space Syntax-guided Post-training for Residential Floor Plan Generation

Pre-trained generative models for residential floor plans are typically optimized to fit large-scale data distributions, which can under-emphasize critical architectural priors such as the configurational dominance and connectivity of domestic public spaces (e.g., living rooms and foyers). This paper proposes Space Syntax-guided Post-training (SSPT), a post-training paradigm that explicitly inject...

Feb 26 2026 2602.22507v1
Early Risk Stratification of Dosing Errors in Clinical Trials Using Machine Learning

Objective: The objective of this study is to develop a machine learning (ML)-based framework for early risk stratification of clinical trials (CTs) ac...

Feb 25 2026 2602.22285v1
Evaluation of six different tests for Schistosoma haematobium diagnosis in a near-elimination setting: a prospective observational diagnostic accuracy study

Background Accurate diagnostic tools are needed in schistosomiasis elimination settings to determine prevalence thresholds for assigning or stopping i...

Biomedical Large Language Models and Prompt Engineering for Causality Assessment of Individual Case Safety Reports in Pharmacovigilance

Background: Biomedical Large Language Models (LLMs) combined with prompt engineering offer domain-specific reasoning, yet their application to individ...

Mobile-O: Unified Multimodal Understanding and Generation on Mobile Device

Unified multimodal models can both understand and generate visual content within a single architecture. Existing models, however, remain data-hungry a...

Feb 23 2026 2602.20161v2
Genomic Evolution of SARS-CoV-2 Delta Variants Pre- and Post-Omicron Emergence using Alignment-free Machine Learning models

The SARS-CoV-2 Delta variant (B.1.617.2), initially classified as a variant of concern due to its enhanced transmissibility and vaccine-escape mutatio...

Mobile-O: Unified Multimodal Understanding and Generation on Mobile Device

Unified multimodal models can both understand and generate visual content within a single architecture. Existing models, however, remain data-hungry a...

Feb 23 2026 2602.20161v1
Life-course comorbidity patterns and integrated prediction of postpartum depression, multimorbidity, and symptom progression

Perinatal depression (PD) is common and disabling, yet its longitudinal comorbidity patterns and predictability remain poorly understood. This study l...

FAIL: Flow Matching Adversarial Imitation Learning for Image Generation

Post-training of flow matching models-aligning the output distribution with a high-quality target-is mathematically equivalent to imitation learning. ...

Feb 12 2026 2602.12155v1
In-Hospital Stroke Prediction from PPG-Derived Hemodynamic Features

The absence of pre-hospital physiological data in standard clinical datasets fundamentally constrains the early prediction of stroke, as patients typi...

Feb 10 2026 2602.09328v1
ECG-IMN: Interpretable Mesomorphic Neural Networks for 12-Lead Electrocardiogram Interpretation

Deep learning has achieved expert-level performance in automated electrocardiogram (ECG) diagnosis, yet the "black-box" nature of these models hinders...

Feb 10 2026 2602.09566v1
Early Detection of Absurdity Signals in Pharmacovigilance: A Machine Learning Ensemble Approach to Identify Rare Adverse Drug Reactions

Background: Traditional pharmacovigilance methods based on biostatistical approaches systematically exclude outliers and rare events, potentially miss...

MeDocVL: A Visual Language Model for Medical Document Understanding and Parsing

Medical document OCR is challenging due to complex layouts, domain-specific terminology, and noisy annotations, while requiring strict field-level exa...

Feb 6 2026 2602.06402v1
GaussianPOP: Principled Simplification Framework for Compact 3D Gaussian Splatting via Error Quantification

Existing 3D Gaussian Splatting simplification methods commonly use importance scores, such as blending weights or sensitivity, to identify redundant G...

Feb 6 2026 2602.06830v1
GRP-Obliteration: Unaligning LLMs With a Single Unlabeled Prompt

Safety alignment is only as robust as its weakest failure mode. Despite extensive work on safety post-training, it has been shown that models can be r...

Feb 5 2026 2602.06258v1
Drug Safety Agents Using Graphs and Ontologies

In pharmacovigilance, analyzing drug safety cases is often time consuming due to the abundance of laboratory data, complex medical histories, and intr...

Predicting Post-Stroke Aphasia Speech Performance from Multimodal Data with Explainable Machine Learning

Aphasia, an acquired language deficit, is the most common post-stroke focal cognitive impairment, and roughly 60% cases become chronic (duration >6 mo...

Community Detection and Patient Experience Analysis in Reddit Conversations on Janus Kinase Inhibitors using Large Language Models

The emergence of Janus kinase (JAK) inhibitors, a relatively new class of medications for autoimmune and inflammatory conditions, has been accompanied...

Stroke Lesions as a Rosetta Stone for Language Model Interpretability

Large language models (LLMs) have achieved remarkable capabilities, yet methods to verify which model components are truly necessary for language func...

Feb 3 2026 2602.04074v1
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