Psoriasis

Artificial intelligence in dermatologic pharmacokinetics: quantitative modeling, clinical translation, and optimization of precision therapeutics.

INTRODUCTION: Dermatology is rapidly transitioning from broad-spectrum therapies toward biologics, nanotechnology-based drug delivery, and precision therapeutics, placing pharmacokinetics (PK) at the center of treatment optimization. Conventional PK approaches are limited by the complexity of skin biology, inter-individual variability, and heterogeneous real-world clinical settings. Artificial int...

Covariance-Inverse Fusion: Toward Comprehensive Proxies for Zero-Shot Neural Architecture Search.

Zero-cost proxy fusion for neural architecture search (NAS) shows potential for efficient architecture evaluation. However, current proxy fusion methods still require extensive ground-truth samples for proxy generation and validation, incurring high computational cost. One of the keys to overcoming this challenge lies in developing automated fusion mechanisms that efficiently integrate the complem...

CoSP: Reconfigurable Metamaterial Inverse Design via Contrastive Pretrained Large Language Model.

Metamaterials for light manipulation at subwavelength scales face significant design challenges due to their complex and sophisticated structures, lea...

EnerBridge-DPO: Energy-Aware Markov Bridge Inverse Folding for Protein Sequence Design.

Designing protein sequences with favorable predicted energetic properties is an important challenge in protein inverse folding, because many existing ...

Sex-specific associations of the bilirubin-to-albumin ratio with lung cancer risk: evidence from Cox regression and causal survival forest analysis.

BACKGROUND: The bilirubin-to-albumin (BA) ratio may reflect the balance between circulating bilirubin and albumin-related binding capacity, but its as...

Artificial Intelligence, Machine Learning, and Multi-Omics Biomarker Discovery in Ectopic Pregnancy: A Comprehensive Review.

BACKGROUND: Ectopic pregnancy is a major cause of first-trimester maternal morbidity and mortality, with diagnosis and management posing persistent cl...

Deep Learning-based Automated Segmentation of Ultra-Widefield Retinal Vasculature for Cardiometabolic Disease Association Analysis.

Retinal vessel analysis in ultra-widefield (UWF) images provides a unique opportunity for large-scale assessment of systemic microvascular health. How...

Response to letter regarding…letter to the editor-Evaluation of the clinical applicability of artificial intelligence in determining systemic therapy indications and treatment selection in psoriasis.

Interpretable AI to predict anal cancer local failure at 3 years with the FFCD Anabase prospective multicentric cohort.

PURPOSE: Machine learning (ML) has transformed oncological risk prediction by enabling personalized therapeutic strategies. Local tumor control remain...

Systems biology integration of miR-mRNA profiles identifies steroid refractoriness mechanisms and biomarker candidates in ulcerative colitis.

Approximately 60% of patients with ulcerative colitis (UC) show steroid resistance or dependence, underscoring the need for biomarkers predicting ther...

Reference-Free large language model agents for physician-guided radiotherapy treatment planning.

BACKGROUND: Large language models (LLMs) have recently demonstrated exceptional capabilities, offering the potential to streamline workflows and enhan...

Application of a novel age estimation model based on permanent maxillary canine morphometric features in a Japanese population.

OBJECTIVES: This study aims to clarify the growth curves of the long axis and apical foramen diameter of permanent maxillary canines (PMCs), and to cr...

From Uniformity to Individuality: Computational Modelling Provides a Mechanistic Rationale for Weight-Adjusted Botulinum Neurotoxin A Dosing.

Fixed-dose Botulinum neurotoxin type A regimens ignore patient-specific variables, such as body weight, despite allometric principles governing the di...

Transdermal delivery of biologics.

Biologics, including peptides, proteins, antibodies, vaccines and nucleic acid-based therapeutics, have transformed the management of chronic, metabol...

Association Between Inflammatory Biomarkers And Carotid Ultrasound Parameters In The Northern Manhattan Stroke Study.

Inflammation contributes to atherosclerosis and vascular remodeling, but the immune pathways associated with distinct carotid ultrasound phenotypes, i...

The High-Intensity Zone: A Dynamic Inflammatory Hub in Lumbar Disc Degeneration.

The lumbar intervertebral disc high-intensity zone (HIZ), a focal hyperintensity within the annulus fibrosus on T2-weighted magnetic resonance imaging...

AI-enabled lyophilization of advanced biologics: process intelligence, quality assessment, and formulation opportunities.

Lyophilization is a key stabilization strategy for advanced biologics, including protein therapeutics, nucleic-acid-based products, extracellular vesi...

Development and validation of an interpretable machine learning model for predicting hypertension risk in patients with psoriasis.

OBJECTIVE: Hypertension is a common yet frequently underdiagnosed comorbidity in psoriasis patients. Early identification and blood pressure control a...

Metabolomic Profiling and Machine Learning-Based Prediction of High-Dose Methotrexate-Induced Liver Injury in Pediatric Acute Lymphoblastic Leukemia.

BACKGROUND: High-dose methotrexate (HD-MTX) is essential for pediatric acute lymphoblastic leukemia (ALL) but frequently causes hepatotoxicity. To add...

[Sarcoidosis-associated uveitis: Current status and future prospects].

Sarcoidosis-related uveitis is the most common manifestation of ocular sarcoidosis. It can occur at any age but preferentially affects adults aged 30 ...