Psoriasis

Dual computational systems in the development and evolution of mammalian brains.

Analyses of brain sizes across mammalian taxonomic groups reveal a consistent pattern of covariation between major brain components, including a robust inverse relationship between the limbic system and the neocortex. To find the functional basis of this relationship, we mapped the multidimensional representations of task-optimized artificial neural networks onto two-dimensional surfaces resemblin...

Racial Differences in the Longitudinal Association Between Perceived Neighborhood Disorder and Allostatic Load.

BACKGROUND AND OBJECTIVES: Neighborhood disorder represents an environmental stressor that contributes to physiological wear and tear on the body, known as allostatic load. This study examines racial differences in the longitudinal associations between perceived neighborhood disorder and allostatic load among middle-aged and older adults. RESEARCH DESIGN AND METHODS: Utilizing a nationally represe...

SOHO State of the Art Updates and Next Questions | Management of Primary Central Nervous System Lymphoma.

Primary Central Nervous System Lymphoma (PCNSL) is a rare and aggressive form of extranodal non-Hodgkin lymphoma. Recent insights into the molecular c...

Development and Validation of Machine Learning Models to Identify Emergency Department Patients at Increased Risk of New or Progressive Acute Kidney Injury.

OBJECTIVES: Acute kidney injury (AKI) is a common and serious condition associated with prolonged hospitalization, chronic kidney disease, and increas...

Fingerprinting organic molecules for the inverse design of two-dimensional hybrid perovskites with target energetics.

Artificial intelligence (AI)-assisted workflows have transformed materials discovery, enabling rapid exploration of chemical spaces of functional mate...

Personalizing treatment of pancreatitis-associated chronic pain: the need for an integrated omics approach.

BACKGROUND: Chronic pancreatitis (CP) is a progressive inflammatory disorder characterized by debilitating chronic pain and substantial healthcare bur...

Overcoming barriers to delivery of biologics by novel approaches and, advanced delivery systems.

Biologics is emerging as fastest growing field of drug development offering specificity and high therapeutic potential. However, their therapeutic eff...

Scenario-based evaluation of large language models for reference accuracy in dermatology: literature retrieval on latent tuberculosis in psoriasis patients on anti-IL-17/23 therapy.

BACKGROUND: Large language models (LLMs) could accelerate clinical literature searches, but their reliability is compromised by "hallucinations" gener...

Cell-type-specific causal effects of CEBPD in CD8 + S100B + Tcells and ZFP36 in monocytes modulate the protective and risk phenotypes in psoriasis.

Psoriasis is a chronic immune-mediated inflammatory skin disease characterized by dysregulated keratinocyte proliferation, immune cell infiltration, a...

AI-guided discovery of the IRF4-PAICS-LDHA axis as a multitarget hub linking tumor metabolism to CD8+ T cell exhaustion in DLBCL.

Diffuse large B-cell lymphoma (DLBCL) features an immunosuppressive tumor microenvironment (TME), yet the molecular drivers connecting metabolic repro...

Unveiling gene perturbation effects through gene regulatory networks inference from single-cell transcriptomic data.

Physiological and pathological processes are governed by networks of genes called gene regulatory networks (GRNs). By reconstructing GRNs, we can accu...

Imaging Immune Heterogeneity in Nasopharyngeal Carcinoma: A Multidimensional Radiomics Perspective.

RATIONALE AND OBJECTIVES: Nasopharyngeal carcinoma (NPC) is characterized by a distinctive virologic and immunologic profile, in which Epstein-Barr vi...

Imaging and genomics in stroke.

Imaging after ischemic and hemorrhagic stroke may allow measurement of key phenotypes of injury and recovery for which targeted therapies are still la...

Identification and validation of KLRB1-related biomarkers in rheumatoid arthritis.

BACKGROUND: Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory disorder. KLRB1 (killer cell lectin like receptor B1), which is intricatel...

ACAT1-mediated lactylation reprogramming governs immune-stromal crosstalk in ulcerative colitis.

Ulcerative colitis (UC), a chronic inflammatory bowel disorder characterized by progressive colonic inflammation, presents escalating global incidence...

Inverse design of an ultra-wideband endfire grooved half-mode waveguide (G-HMWG) antenna based on the CNN approach.

This study presents an AI-assisted inverse design methodology for a compact and ultra-wideband grooved half-mode waveguide (G-HMWG) end-fire antenna. ...

Accelerating photonic gas sensor design: machine learning-driven inverse optimization of silicon photonics Bragg gratings.

Optical gas sensors based on photonic structures offer label-free, real-time detection with high sensitivity, but their design optimization remains co...

Accelerating the Design of High-Entropy Alloys for Hydrogen Storage via Generative Adversarial Networks.

High-entropy alloys (HEAs) have emerged as promising candidates for solid-state hydrogen storage, yet the vast compositional space poses a major chall...

Machine Learning to Predict Remission Between Six and 24 Months in Rheumatoid Arthritis: Insights from the JAK-pot Collaboration.

OBJECTIVE: To develop, externally validate, and simplify a machine-learning (ML) model to predict remission between six and 24 months in rheumatoid ar...

Autonomous inverse modeling of complex groundwater systems via a physics-integrated large language model multi-agent framework.

Inverse modeling of groundwater flow and transport in subsurface systems is fundamentally restricted by the conceptual-numerical gap, where translatin...