Psychiatry

Latest AI and machine learning research in psychiatry for healthcare professionals.

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Electroconvulsive Therapy Drives Sensorimotor Network Segregation in Depression: A Multiscale Edge-Centric Connectomic Study

Background: Electroconvulsive therapy (ECT) induces widespread brain effects and remains the most effective intervention for severe major depressive disorder (MDD). However, how ECT reshapes the global organization of functional connectomes remains poorly understood. Edge-centric connectomics offers a framework for characterizing large-scale reconfiguration beyond conventional node-based analyses....

A Neuro-Symbolic Knowledge Graph and Large Language Model Hybrid Architecture for Multi-Modality Mental Health Counseling

Background: Depression and anxiety are managed largely between clinical visits, yet outpatient care lacks scalable, accountable mechanisms for between-visit support. Large language models converse fluently but fuse clinical reasoning with language generation in one opaque process, so they cannot reliably deliver evidence-based psychotherapy and typically operate outside clinician oversight. Object...

An interpretable omnigenic neural network architecture for the human genome

Genetic prediction of complex phenotypes typically relies on additive linear models, which scale well but cannot capture non-additive effects or deepl...

Neurai-VN Benchmark: Standardized Machine Learning Models for Multimodal Digital Phenotyping in Mental Health Classification

Digital phenotyping (DP) using smartphones and wearable devices has shown considerable potential for mental health monitoring. However, progress remai...

Jul 28 2026 2607.25232v1
Deep Learning for Individual-Level Classification of Schizophrenia Versus Healthy Controls from Trial-Level Auditory Oddball ERP Waveforms

Machine learning approaches may support individual-level classification in psychiatry, but many EEG-based schizophrenia studies have relied on small s...

EMG-BIDS: an extension to the Brain Imaging Data Structure for electromyography

Electromyography (EMG) is fundamental to clinical assessment, rehabilitation, neuromuscular research, and human-machine interfaces. Despite decades of...

Synthetic Speech, Real Signal: Paralinguistic Preservation and Cross-Lingual Augmentation via Voice Cloning

Synthetic data augmentation in speech is common practice for linguistic tasks like ASR, but has seen far less work for paralinguistic ones, especially...

Jul 24 2026 2607.22304v1
Translational Study of using FOCM/TS Metabolites for Supporting Autism Spectrum Disorder Diagnosis

Purpose Several clinical studies have shown correlations between certain physiological measure-ments and an ASD diagnosis. Such findings, however, hav...

How does CBT work? Causal discovery modelling locates the mechanisms of change in cognitive behavioural treatment for eating disorders

Background: Cognitive behavioural therapy (CBT) is the most frequently used and recommended therapy program for mental health conditions, including fo...

Context-dependent facial-expression patterns during affective film viewing in patients with bipolar depression

Background: Emotion dysregulation is a core feature of bipolar disorder (BD), yet its behavioral expression during depressive episodes, and potential ...

PocketPPD: Screening for Postpartum Depression Risk Using Passive Smartphone Sensing

Postpartum depression (PPD) is a serious perinatal mental health condition affecting approximately 20% of new mothers worldwide. Common screening appr...

Jul 19 2026 2607.17185v1
A Preoperative Electroencephalography Signature for Predicting Treatment Response to Deep Brain Stimulation in Obsessive-Compulsive Disorder

Deep brain stimulation (DBS) is effective for treatment-refractory obsessive-compulsive disorder (OCD), but outcomes are heterogeneous and non-respond...

Prompt Engineering Limitations: Preliminary Evaluation of Large Language Models for Psychotherapy Safety

Large Language Models are increasingly used in consumer-facing mental health tools, many of which claim that prompt engineering alone can ensure safe ...

Reconsidering the case against risk prediction in self-harm: routinely collected health data distinguishes groups at higher and lower risk of adverse outcomes following paracetamol overdose

Background. UK clinical guidance recommends that structured risk prediction tools and risk stratification should not be used in self-harm, to predict ...

The topology of adolescent mental health

The increased vulnerability to mental health problems in adolescence is frequently reported but poorly understood, hampered by a rigid diagnostic syst...

Life-Stage Heterogeneity in the Mental Health Treatment Gap: An Unsupervised Machine Learning Profiling of Symptomatic US Adults

Abstract Background Despite a rising global psychiatric burden, a treatment gap persists where the majority of symptomatic individuals remain unmedica...

Conversational trajectory degrades large language model detection of suicidal ideation relative to clinicians: a preregistered study

Background General-purpose large language models increasingly encounter emotional and therapy-like conversation, yet are not developed or evaluated as...

Auditing Construct Overlap in Explainable Machine Learning: Evidence from Burnout-Depression Prediction Across Student Cohorts

Explainable machine learning (XML) pipelines applied to composite mental health outcomes can produce apparently-robust, cross-population-stable risk h...

Jul 12 2026 2607.10633v1
OmicFormer: a statistical priors-informed transformer for accurate and generalizable omics prediction of diseases and complex traits

Precision medicine faces a critical challenge in translating high-dimensional omics data into robust disease predictions across diverse populations. C...

A placental transcriptional signature for autism

Autism development involves multiple genetic and early-life environmental factors. Studying the placenta's gene expression profile may reveal key mech...

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