Psychiatry

Latest AI and machine learning research in psychiatry for healthcare professionals.

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Personalized Insights Derived from Wearable Device Data and Large Language Models to Improve Well-Being

Health behaviors such as physical activity and sleep affect mental health, but the effect of each health behavior varies substantially across individuals, limiting the usefulness of generic behavioral recommendations. We collected one year of continuous wearable and ecological momentary assessment data from 3,139 participants in the Intern Health Study (2018-2023), and examined individual-level as...

Developmental and genetic modulation of evidence integration dynamics in zebrafish sensorimotor decision-making

Animals integrate information over time and maintain persistent internal representations of cues to guide decision-making. How the underlying behavioral algorithms of individual animals depend on factors such as experience, developmental stage, or genotype remains poorly understood. Drift-diffusion models provide a powerful theoretical framework to describe and predict performance metrics across a...

Bias and Fairness in Self-Supervised Acoustic Representations for Cognitive Impairment Detection

Speech-based detection of cognitive impairment (CI) offers a promising non-invasive approach for early diagnosis, yet performance disparities across d...

Mar 3 2026 2603.02937v1
Decomposing response inhibition: a POMDP model

Inhibition is a core cognitive control function whose competence is distributed across the population, with more extreme impairments in psychiatric co...

Global Interpretability via Automated Preprocessing: A Framework Inspired by Psychiatric Questionnaires

Psychiatric questionnaires are highly context sensitive and often only weakly predict subsequent symptom severity, which makes the prognostic relation...

Feb 26 2026 2602.23459v1
Disentangling Symptom Heterogeneity in Large-Scale Psychiatric Text: Domain-Adapted vs. Instruction-Tuned Transformers

Psychiatric disorders are fundamentally challenged by symptom heterogeneity, high comorbidity, and the absence of objective biomarkers, which together...

Precision stratification of risk for suicidal behavior in people with bipolar depression

Patients with bipolar depression are at the highest risk for suicidal behavior, comprising ~10% of all deaths. In the critical period preceding attemp...

Transforming Behavioral Neuroscience Discovery with In-Context Learning and AI-Enhanced Tensor Methods

Scientific discovery pipelines typically involve complex, rigid, and time-consuming processes, from data preparation to analyzing and interpreting fin...

Feb 19 2026 2602.17027v1
Life-course comorbidity patterns and integrated prediction of postpartum depression, multimorbidity, and symptom progression

Perinatal depression (PD) is common and disabling, yet its longitudinal comorbidity patterns and predictability remain poorly understood. This study l...

Development and cross-tissue validation of a methylation profile score for the cortisol response to stress

Hypothalamic-pituitary-adrenal axis (HPA axis) dysregulation is a risk factor for poor mental and physical health. Animal studies indicate that DNA me...

Disparities, Perceived Discrimination, and Patient-Clinician Communication in Alcohol Use Disorder Treatment: An All of Us Cohort Study

Background and Aims: Alcohol use disorder (AUD) remains a major public health concern, with persistent disparities in access to evidence-based treatme...

Brain morphological pattern is associated with the presence, severity, and transition of transdiagnostic psychiatric disorders in preadolescents

Cognitive function, psychological processes, mental states, and behaviors are key dimensions of human subjective experience that separately relate to ...

Reproducible symptom subtypes of depression identified using unsupervised machine learning

Depression is a heterogeneous disorder, often diagnosed based on symptom co-occurrence. However, individuals may present with markedly different sympt...

Application of Explainable AI in Neuroscience: Enhancing Autism Screening

The main challenges in the life of a child with autism are difficulties in communication, behavior, and social interaction. Early diagnosis of this ne...

Generating Biologically Relevant Subtypes of Autism Spectrum Disorder with differential responses to Acute Oxytocin Administration in a Randomized Trial using Random Forest Models and K-means Clustering

Autism Spectrum Disorder (ASD) is a heterogenous condition that has no biologically relevant subtypes yet. Here, we utilized a multidimensional approa...

Development and validation of neurological health score using machine learning algorithms

Neurological health score (NHS), indicating the health of brain and nervous system, helps in identifying high risk individuals, and in recommending li...

Exploring the Influence of Lifestyle, Social Health, and Demographic Factors on Psychological Well-being and Engagement Levels

Loneliness and psychological well-being are increasingly recognized as critical public health concerns, yet their multi-factorial determinants remain ...

When attention falters: brain, breathing, and behavioral signals of lapses in interoceptive attention

Mind-body practices like meditation and yoga, which are widely used to support mental health, involve paying attention to internal bodily sensations l...

Diagnostic Accuracy and Clinical Reasoning of Multiple Large Language Models in Psychiatry

Importance: Large language models (LLMs) have demonstrated diagnostic potential in several medical specialties, but their application to psychiatry - ...

Early Pregnancy DNA Methylation Signatures as Predictors of Antenatal Depressive Symptoms: A longitudinal study of DNA methylation changes

Background. Antenatal depressive symptoms (ADS) are common and underdiagnosed, particularly in low and middle income countries, and are associated wit...

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