Public Health & Policy

Toward Timely Diagnosis of Pancreatic Cancer: Revolutionizing Early Detection Through Genomics, Artificial Intelligence, and Noninvasive Biomarkers.

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive cancers, typically diagnosed at an advanced stage due to its subtle and often absent early symptoms. Despite representing only 3% of new cancer cases, it is projected to become the second leading cause of cancer-related deaths by 2030. Currently, early diagnosis remains a significant challenge, and survival rate...

Artificial intelligence in combating challenges in antimicrobial resistance: a narrative review.

Antimicrobial resistance (AMR) is a major global health challenge that threatens the effective prevention and treatment of infections. It arises from increasing resistance rates, limited diagnostic capacity, inappropriate antimicrobial use, and a declining pipeline of new antibiotics. These challenges highlight the need for innovative approaches to complement existing AMR control strategies. Artif...

Development of a Predictive Calculator for the Need for Abdominoperineal Resection after Chemoradiation Therapy in Anal Squamous Cell Carcinoma.

BACKGROUND: Chemoradiation therapy (CRT) is standard treatment for anal squamous cell carcinoma (ASCC). Abdominoperineal resection (APR) is usually re...

Prevalence and factors associated with suicidal ideation based on the Malaysia National Health and Morbidity Survey: A machine learning analysis.

BACKGROUND: This study estimated the prevalence of past-two-week suicidal ideation and examined its demographic, clinical, and health-related correlat...

Early Detection and Surveillance of Infectious Disease Outbreaks in Nigeria  : Integrating Nigerian Pidgin English (NPE) into the EPIWATCH® Platform.

This study aimed to integrate Nigerian Pidgin English (NPE) into the Artificial Intelligence system EPIWATCH®, with the aim of providing early detecti...

Empowering Alzheimer's and Related Dementia Prevention Through Primary Care Using Responsible AI: A Pilot Walk-in Memory Sync Booth.

Alzheimer's disease and related dementias (ADRD) remain underdiagnosed early due to reliance on costly, invasive, and time-intensive assessments, prom...

Early detection of female-specific cancers using longitudinal healthcare records with a multichannel convolutional neural network.

OBJECTIVES: Female-specific cancers, including breast, ovarian, cervical and uterine malignancies, lack comprehensive early detection approaches, part...

Drone-based geospatial prediction modeling identifies Fasciola hepatica infection risk in the Cusco Highlands of Peru.

BACKGROUND: Fascioliasis is a neglected infectious disease affecting agricultural communities worldwide, with the Peruvian Andes among the most severe...

[Sudden cardiac death in structural heart disease : Update on prevention].

Sudden cardiac death (SCD) remains one of the leading causes of death despite major advances in cardiovascular diagnostics and treatment. Evidence sup...

Unraveling immune evasion in the tumor microenvironment: Mechanisms, therapeutic strategies, and future directions in cancer immunotherapy.

The immune evasion that is encouraged by the tumor microenvironment (TME) is a key factor in the failure of cancer immunotherapies. This review addres...

Expert Consensus on Ethical Governance for Clinical Applications of Generative Medical Artificial Intelligence(2025 Edition).

The research and innovative applications of generative medical artificial intelligence(GMAI)are rapidly advancing in the healthcare field.Significant ...

Criteria to Assess the Predictive and Clinical Utility of Novel Models, Biomarkers, and Tools for Risk of Cardiovascular Disease: A Scientific Statement From the American Heart Association.

Risk prediction has been used in the primary prevention of cardiovascular disease for >3 decades. Contemporary cardiovascular risk assessment relies o...

Sleep Disorders and Male Infertility: Integrated Mechanisms and Precision Therapeutic Strategies.

BACKGROUND: Male factor infertility accounts for nearly half of infertility cases worldwide, yet modifiable lifestyle-related risk factors remain insu...

Facing the Silent Crisis: Suicidal Ideation and Suicide in the Nursing Profession.

BACKGROUND: This manuscript explores the silent yet urgent crisis of suicidal ideation and suicide within the nursing profession. Despite being one of...

Clinical impact of adopting an AI-driven opportunistic bone health screening software using routine X-ray.

OBJECTIVES: To evaluate the clinical impact of an artificial intelligence device, Rho, that opportunistically screens X-rays for low bone mineral dens...

AI-Enabled Surveillance and Modelling for Counterfeit Botulinum Toxin A: Risk Projection, Patient Safety, and Systemic Reform of Pharmacovigilance.

BACKGROUND: Counterfeit Botulinum Toxin A (BoNT-A) poses a growing global threat, particularly in aesthetic medicine where regulatory oversight is min...

Strategies for Safer Cefepime Use to Prevent Neurotoxicity Using the Electronic Health Record.

Cefepime, a cornerstone antibiotic in critical care, is associated with underrecognized cefepime-induced neurotoxicity (CIN), particularly in patients...

Multi-model large-scale AI framework for avian influenza surveillance and preparedness: Harnessing large language models to enhance risk communication, real-time decision support, and public health response strategies.

Avian influenza remains a persistent threat to global health security, with serious consequences for food systems, trade, and pandemic preparedness. T...

Data-driven subgroups for 3-year risk stratification of incident diabetes and complications in diabetes-free Chinese adults.

BACKGROUND: Substantial metabolic heterogeneity exists prior to the development of diabetes, creating opportunities for earlier and more precise inter...

Atopic Dermatitis in Denmark: Regional Variation.

Using national registers, this study investigates regional variations in the number of individuals with and treatment of atopic dermatitis (AD) in Den...