Pulmonology

Latest AI and machine learning research in pulmonology for healthcare professionals.

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Multi-Omics Integration for Identification of Prognostic Molecular Signatures for Survival Stratification in Lung Cancer

Lung cancer is characterized by profound intratumoral and inter-patient heterogeneity, spanning histological subtypes, molecular landscapes, and the tumor microenvironment. While multi-omics integration is essential for capturing this complexity, leveraging these data to explicitly define survival-associated subpopulations remains a significant challenge. In this study, we developed NeuroMDAVIS-FS...

A Diffusion-Driven Fine-Grained Nodule Synthesis Framework for Enhanced Lung Nodule Detection from Chest Radiographs

Early detection of lung cancer in chest radiographs (CXRs) is crucial for improving patient outcomes, yet nodule detection remains challenging due to their subtle appearance and variability in radiological characteristics like size, texture, and boundary. For robust analysis, this diversity must be well represented in training datasets for deep learning based Computer-Assisted Diagnosis (CAD) syst...

Mar 2 2026 2603.01659v1
DiffusionXRay: A Diffusion and GAN-Based Approach for Enhancing Digitally Reconstructed Chest Radiographs

Deep learning-based automated diagnosis of lung cancer has emerged as a crucial advancement that enables healthcare professionals to detect and initia...

Mar 2 2026 2603.01686v1
Development of a Multi-Trait Polygenic Score for Intrinsic Capacity

Background: Intrinsic capacity (IC) is a key marker of healthy ageing, which captures an individuals physical and mental capacities, measured across f...

Multimodal EHR-Based Prediction of Pediatric Asthma Exacerbations

Pediatric asthma exacerbations are a frequent cause of emergency department (ED) visits and hospitalizations, yet accurate risk prediction remains lim...

Quantification of the effects of single nucleotide variants in NKX2.1 transcription factor binding sites

Transcription factors recognise and bind specific DNA sequence patterns in promoters and enhancers thereby regulating gene expression. Variations in t...

Identifying severe COVID-19 risk variants modulating enhancer reporter activity in lung cells

Common genetic variants contribute to risk for complex human diseases. However, despite thousands of associations, variants modulating disease risk an...

Can Agents Distinguish Visually Hard-to-Separate Diseases in a Zero-Shot Setting? A Pilot Study

The rapid progress of multimodal large language models (MLLMs) has led to increasing interest in agent-based systems. While most prior work in medical...

Feb 26 2026 2602.22959v1
What Topological and Geometric Structure Do Biological Foundation Models Learn? Evidence from 141 Hypotheses

When biological foundation models such as scGPT and Geneformer process single-cell gene expression, what geometric and topological structure forms in ...

Feb 25 2026 2602.22289v1
Large-Language Models for data extraction from written kidney biopsy reports

Introduction: Kidney biopsy reports contain rich information that is clinically actionable and useful for research. However, the narrative format hind...

Data-Driven Hybrid Model of SARIMA-CNNAR For Tuberculosis Incidence Time Series Analysis in Nepal

Abstract Background Tuberculosis (TB) remains a major public health challenge in Nepal, with incidence rates substantially higher than global estimate...

Deep learning extracts MoA-specific signatures from high-throughput images of chemically and genetically perturbed Corynebacteria

Tuberculosis (TB) is the worldwide leading infectious killer due to a single pathogen and increasing antimicrobial resistance (AMR) makes it imperativ...

Using Unsupervised Domain Adaptation Semantic Segmentation for Pulmonary Embolism Detection in Computed Tomography Pulmonary Angiogram (CTPA) Images

While deep learning has demonstrated considerable promise in computer-aided diagnosis for pulmonary embolism (PE), practical deployment in Computed To...

Feb 23 2026 2602.19891v1
IPv2: An Improved Image Purification Strategy for Real-World Ultra-Low-Dose Lung CT Denoising

The image purification strategy constructs an intermediate distribution with aligned anatomical structures, which effectively corrects the spatial mis...

Feb 22 2026 2602.19314v1
Deep learning-derived quantitative interstitial abnormalities in early rheumatoid arthritis and healthy controls: A multicenter, prospective cross-sectional study

Objective: Quantitative computed tomography (QCT) can automatically quantify parenchymal abnormalities on chest CT imaging using deep learning. We lev...

CardioPulmoNet: Modeling Cardiopulmonary Dynamics for Histopathological Diagnosis

Objective: This study investigates whether incorporating physiological coupling concepts into neural network design can support stable and interpretab...

GPAS: an online AI system for rapid and accurate pathogen identification and LLM-based interpretation

Accurate identification of unknown pathogens is critical for medicine and public health, yet current metagenomic workflows remain heavily dependent on...

Obscuration to Clarity: Bone Suppression for Enhanced Localization in Pneumothorax Segmentation of Chest Radiographs

Chest radiography (CXR) is a primary modality for assessing cardiopulmonary conditions, but its effectiveness is limited by anatomical obstructions (e...

3D, multi-omic imaging reveals molecular biomarkers of the pre-metastatic niche in lung cancer

The recurrence rate following complete surgical resection of primary non-small cell lung cancer is as high as 55%, yet no approach currently exists to...

Comparing Modelling Architectures in the context of EGFR Status Classification in Non Small Cell Lung Cancer

Radiogenomics enables the non invasive characterisation of the genomic and molecular properties of tumours, with epidermal growth factor receptor (EGF...

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