Pulmonology

Latest AI and machine learning research in pulmonology for healthcare professionals.

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De novo design of a safe and potent respiratory syncytial virus immuno-focusing antigen

Respiratory syncytial virus (RSV) remains the leading cause of severe respiratory infections in infants, the elderly, and the immunocompromised. Although stabilized full-length pre-fusion (pre-F) protein vaccines are promising, enhanced respiratory disease (ERD) remains a critical safety concern. Here, we used artificial intelligence to design a de novo immuno-focused antigen that structurally pre...

Why Large Language Models' Clinical Reasoning Fails: Insights from Explainable Deep Learning

BACKGROUND Medical large language models (LLMs) achieving high benchmark accuracy exhibit unexplained variability in clinical tasks, producing errors that clinicians cannot safeguard against. Sparse autoencoders offer a mechanistic interpretability approach to reveal how models represent medical knowledge and why they fail. METHODS We evaluated clinical reasoning stability in GPT-5, MedGemma-27B-T...

Foundation Model Robustness to Technical Acquisition Parameters in Chest X-Ray AI A Multi-Architecture Comparative Study with External Validation

Background Foundation models have emerged as a promising paradigm for medical imaging AI [7], with claims of improved generalization and reduced bias....

Deep Learning-Based Spatial Immunoprofiling of Multiplex Immunofluorescence Images Distinguishes Tuberculosis Disease States in Diversity Outbred Mice

Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb), remains a major global health challenge, with approximately 10.8 million new cases and...

Tri-Reader: An Open-Access, Multi-Stage AI Pipeline for First-Pass Lung Nodule Annotation in Screening CT

Using multiple open-access models trained on public datasets, we developed Tri-Reader, a comprehensive, freely available pipeline that integrates lung...

Jan 27 2026 2601.19380v1
LungCRCT: Causal Representation based Lung CT Processing for Lung Cancer Treatment

Due to silence in early stages, lung cancer has been one of the most leading causes of mortality in cancer patients world-wide. Moreover, major sympto...

Jan 26 2026 2601.18118v1
Generative Diffusion Augmentation with Quantum-Enhanced Discrimination for Medical Image Diagnosis

In biomedical engineering, artificial intelligence has become a pivotal tool for enhancing medical diagnostics, particularly in medical image classifi...

Jan 26 2026 2601.18556v1
A Hybrid Rule-Based and Deep Learning Framework for Ventilator Waveform Segmentation and Delineation

Accurate assessment of patient-ventilator interaction is critical for optimizing respiratory support and detecting harmful dyssynchronies linked to ad...

PC-MCL: Patient-Consistent Multi-Cycle Learning with multi-label bias correction for respiratory sound classification

Automated respiratory sound classification supports the diagnosis of pulmonary diseases. However, many deep models still rely on cycle-level analysis ...

Jan 23 2026 2601.17080v1
AI-Powered Acoustic Surveillance for Early Detection of Calf Respiratory Disease

Effective management of Bovine Respiratory Disease Complex (BRDC) requires timely, non-invasive diagnostic tools to protect calf health and welfare. A...

Quantifying the oxygen preferences of bacterial communities using a metagenome-based approach

Oxygen is a primary driver of the distribution and activity of microbial life. Since oxygen levels are often difficult to measure in situ, one potenti...

Technical Acquisition Parameters Dominate Demographic Factors in Chest X-ray AI Performance Disparities: A Multi-Dataset External Validation Study

Artificial intelligence systems for chest radiograph interpretation are increasingly deployed in clinical practice, yet current fairness frameworks em...

AI-generated data contamination erodes pathological variability and diagnostic reliability

Generative artificial intelligence (AI) is rapidly populating medical records with synthetic content, creating a feedback loop where future models are...

Transfer Learning from One Cancer to Another via Deep Learning Domain Adaptation

Supervised deep learning models often achieve excellent performance within their training distribution but struggle to generalize beyond it. In cancer...

Jan 21 2026 2601.14678v1
LLM Augmented Intervenable Multimodal Adaptor for Post-operative Complication Prediction in Lung Cancer Surgery

Postoperative complications remain a critical concern in clinical practice, adversely affecting patient outcomes and contributing to rising healthcare...

Jan 20 2026 2601.14154v1
Spatial Decoding of Tertiary Lymphoid Structure Maturation in Non-Small Cell Lung Cancer Using Deep Neural Networks

Understanding the role of tertiary lymphoid structures (TLS) is crucial in non-small cell lung cancer (NSCLC), as they are associated with patient pro...

ComPRePS: Unlocking Scalable AI Analysis for Computational Renal Pathology

Digital pathology using whole slide imaging (WSI) and artificial intelligence (AI) has the potential to transform diagnostic workflows, but adoption r...

Seeing Isn't Always Believing: Analysis of Grad-CAM Faithfulness and Localization Reliability in Lung Cancer CT Classification

Explainable Artificial Intelligence (XAI) techniques, such as Gradient-weighted Class Activation Mapping (Grad-CAM), have become indispensable for vis...

Jan 19 2026 2601.12826v1
AI-generated data contamination erodes pathological variability and diagnostic reliability

Generative artificial intelligence (AI) is rapidly populating medical records with synthetic content, creating a feedback loop where future models are...

Jan 19 2026 2601.12946v1
GEOGRAPHIC DOMAIN SHIFT PRECIPITATES DIVERGENT FAILURE MODES IN DEEP LEARNING BASED TUBERCULOSIS SCREENING: A MULTI-NATIONAL EXTERNAL VALIDATION STUDY

Background: Deep learning algorithms for tuberculosis (TB) screening frequently achieve radiologist-level performance during internal evaluation, yet ...

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