Latest AI and machine learning research in pulmonology for healthcare professionals.
The upper airway epithelium in humans is maintained in homeostasis by a resident population of basal stem cells. In the presence of tobacco smoke these gain mutations that significantly increase their risk of transformation to lung squamous cell carcinoma. A small proportion of stem cells avoid the mutational damage caused by carcinogens in tobacco and are more abundant in the lungs of former smok...
Accurate fibrosis quantification is essential for understanding muscle and cardiac disease, yet current manual and semi–automated methods remain slow, subjective, and poorly reproducible. We introduce FibroTrack, a standalone deep learning platform with a graphical user interface (GUI) that fully automates fibrosis analysis across Sirius Red (SR), Masson’s Trichrome (MT), and immunohistochemistry ...
The nasopharyngeal microbiome acts as a dynamic interface between the human body and environmental exposures, modulating immune responses and helping ...
The liver’s microenvironment consists of interconnected vascular, biliary, and neural networks that regulate homeostasis and disease progression. Howe...
Rigorous and reproducible evaluation of lung tissue under different conditions is necessary to interpret development, injury, and pharmacologic interv...
Antibodies play a central role in neutralizing pathogens through direct interference with viral entry and recruitment of effector immune cells. Howeve...
Genome-scale DNA methylation (DNAm) profiles capture organismal physiology, but most predictive models lack transparency and multi-level applicability...
Protein language models (PLMs) are often assumed to capture evolutionary information by training on large protein sequence datasets. Yet it remains un...
Pyrazinamide is an important first-line antibiotic for treating tuberculosis and resistance is primarily caused by mutations in the pncA gene. Traditi...
Inflammation is central to pulmonary arterial hypertension (PAH) pathogenesis. The liver regulates systemic immunity, yet its contribution to PAH rema...
Hemoglobin (Hb), a well-characterized protein central to oxygen transport and molecular medicine, serves as a model for studying how sequence variatio...
Histologically stained tissue sections are considered the gold standard for studying microscopic anatomy and diagnosing disease in clinical practice. ...
Despite growing evidence implicating cellular senescence in tumor progression, methodological challenges in objectively quantifying senescent cell bur...
Histological analysis is a cornerstone of preclinical respiratory disease research, enabling assessment of pathology, therapeutic effects, and mechani...
Cystic fibrosis (CF) alters gut physiology, yet its impact on microbial communities across colonic regions (ascending, transverse, descending colon) a...
The first malaria parasite Plasmodium falciparum genome published in 2002 jump-started functional studies, but a large fraction of all predicted prote...
Each stage of neuronal development (i.e., proliferation, differentiation, migration, neurite outgrowth and synapse formation) requires functional and ...
Predicting heterogeneous and non-linear processes remains a fundamental challenge in Earth sciences. Here, we present an artificial intelligence (AI)-...
Primary ciliary dyskinesia (PCD) is a genetic condition that results in dysmotile cilia and abnormal mucociliary clearance. Despite advances in unders...
Immune checkpoint blockade has emerged as a promising form of cancer therapy. However, only some patients respond to checkpoint inhibitors, while a si...