Pulmonology

Latest AI and machine learning research in pulmonology for healthcare professionals.

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Early Identification of High-Risk Individuals for Mortality after Lung Transplantation: A Retrospective Cohort Study with Topological Transformers

Lung transplantation remains the only definitive treatment for patients with end-stage respiratory failure; however, it is burdened by a substantial risk of post-operative mortality. Current risk stratification methods, such as the Lung Transplant Risk Index, offer limited predictive performance and interpretability. This study introduces a novel predictive model based on topological transformers ...

Systems Vaccinology Reveals Distinct Immune Signatures of Inhaled and Intramuscular SARS-CoV-2 Vaccination in Humans

Mucosal vaccines may reduce both infection and transmission by engaging local immunity, yet the immunological pathways they activate in humans remain poorly defined. Here, we present a comprehensive systems vaccinology analysis of a Modified Vaccinia virus Ankara (MVA)-based SARS-CoV-2 vaccine candidate tested in two distinct phase 1 clinical trials as a booster vaccination with either inhaled or ...

Combination AI-Machine Learning to Diagnose Pulmonary Hypertension: A Real-World Evidence Cohort Study

Pulmonary hypertension (PH) is a highly morbid disease, but underdiagnosis is common outside of expert referral centers. Consequentially, there may be...

A Prospective Real-time Early Warning System to Anticipate Onsets and Peaks of Respiratory Diseases Outbreaks at the State Level in the U.S. A Transfer Learning Approach Leveraging Digital Traces

Respiratory disease outbreaks burden U.S. healthcare systems with over one million hospitalizations annually, yet current surveillance systems lag 1-2...

Admission photoplethysmography-based mortality prediction in hospitalized Ugandan children with suspected or confirmed infection: a feasibility study

Sepsis remains a major cause of preventable pediatric hospital deaths in developing countries, with progress hindered by the lack of effective risk id...

Neural network-based identification of easily-obtainable demographic and clinical characteristics to identify people with tuberculosis

We consider the application of machine learning to the classification of tuberculosis (TB) based on clinical and demographic data. Such data is routin...

From text to tables: Zero-shot extraction of structured clinical data from free-text CT scan reports using foundational large language models

Large language models (LLMs) are being explored for multiple applications in medical research, including medical text classification. We evaluate the ...

Validation of virtual trichrome stains for kidney fibrosis evaluation using dual-mode emission and transmission microscopy

Assessment of interstitial fibrosis is essential in the diagnosis and prognosis of kidney diseases. However, current histologic scoring methods using ...

Prediction of Pulmonary Vein Isolation and Gap Recurrence on 12-Lead ECG Using Deep Learning

Pulmonary vein isolation (PVI) is key to atrial fibrillation (AF) ablation, but arrhythmia often recurs due to conduction gaps permitting pulmonary ve...

Real-world before-and-after evaluation of AI support for lung cancer diagnosis at three US lung nodule clinics

Health systems and payers require evidence that artificial intelligence (AI)-enabled decision support improves care delivery. Integrating AI into lung...

Employing Consensus-Based Reasoning with Locally Deployed LLMs for Enabling Structured Data Extraction from Surgical Pathology Reports

Surgical pathology reports provide essential diagnostic information critical for cancer staging, treatment planning, and cancer registry documentation...

A photoplethysmography-based aging clock reveals genetic determinants of arterial aging

Arterial aging, marked by progressive vascular stiffening, is a contributor to cardiovascular disease. Photoplethysmography (PPG) waveforms offer an e...

Microscale Multiplexed Antigen-Specific Antibody Fc Profiling for Point-of-Care Diagnosis of Tuberculosis

Accurate, affordable tuberculosis (TB) diagnostics that do not require sputum samples are urgently needed for TB control and elimination. Prior serolo...

Radiologic, Pathologic, and Deep Learning Predictors of Response to Immune Checkpoint Blockade in Renal Cell Carcinoma Patients Undergoing Post-Treatment Nephrectomy

Response assessment of primary kidney tumors in the consolidation cytoreductive and neoadjuvant settings offers a unique opportunity to inform postope...

Brain activity as a candidate biomarker for personalised caffeine treatment in premature neonates

Medication in hospitalised infants is often prescribed using a ‘one-size-fits-all’ approach due to lack of clinical biomarkers. Caffeine is one of the...

Wearable Sleep Measures May Improve Machine Learning Prediction of Home-based Pulmonary Rehabilitation Engagement Among Patients With Chronic Obstructive Pulmonary Disease: A Proof-of-Concept Study

To evaluate whether incorporating baseline sleep measures from a wrist-worn activity monitor in machine learning (ML) models improved the prediction o...

Optimizing Lightweight Medical AI for Chest CT Classification: A Distillation and Quantization Approach

Medical imaging has been crucial in the diagnostics of pulmonary diseases and the use of chest CT scans is a fundamental diagnostic tool in lung cance...

Scaling genetic discovery for organ volumes using machine learning-assisted imputation and bias-corrected GWAS

MRI-derived organ and tissue volumes are powerful endophenotypes for studying complex disease, but their availability is limited by cost and throughpu...

Development of a Multi-Model Ensemble Tool for Early Prediction of 48-Hour Respiratory Failure Risk in CAP Patients

To develop a predictive tool capable of early identification of the risk of acute respiratory failure within 48 hours of hospital admission in patient...

Developing an Early Diagnostic Signature and Deciphering the Microbial-Host Dynamics in Lower Respiratory Tract Infection (LRTI) in Paediatric Intensive Care Unit (PICU) Patients

Lower respiratory tract infection (LRTI) is a leading cause of morbidity and mortality among children admitted to paediatric intensive care units (PIC...

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