Rheumatoid Arthritis

The Overlooked Autoantibody Repertoire: Exploring the Biomarker Potential of Downregulated Autoantibodies in NSCLC.

Autoantibodies (AAbs) represent promising biomarkers in cancer. While most AAbs are elevated in cancer, a substantial subset is downregulated, and their diagnostic and prognostic potential remains largely unexplored. Here we used the HuProt protein microarray to identify downregulated AAbs in non-small cell lung cancer (NSCLC) serum. Indirect ELISA quantified serum levels in 781 samples. Ten machi...

Fragment-based drug design coupled with AI/ML prediction enables identification of novel PARP-1 inhibitors against triple-negative breast cancer.

Triple-negative breast cancer occurs as a formidable challenge in cancer research due to the characteristically aggressive behaviour, poor prognosis, and scarce availability of treatment options. The approval of PARP-1 inhibitors against Triple-negative Breast Cancer (TNBC) paves the way for drug discovery endeavours in this arena. The research work aimed to identify PARP-1 targeting novel inhibit...

Deep-Q-Network in Multiview Ensemble Learning to Predict Anti-diabetic Peptide and Diabetic Types.

Diabetes mellitus disease has become a significant human health concern globally, causing cardiovascular complications, kidney disease, cerebrovascula...

The Anti-proliferative and Pro-apoptotic Effects of Iranian Viper Venom (Vipera raddei kurdistanica) on Human Gastric Cancer Cells (C615) are Mediated by PI3K/AKT/mTOR Signalling Pathway Inhibition.

OBJECTIVE: Gastric cancer (GC) is one of the most common malignancies worldwide. Since the PI3K/AKT/mTOR signalling pathway plays a crucial role in tu...

Diagnostic model and identification of IGFBP2 as an aging-related biomarker and therapeutic target for systemic sclerosis-associated interstitial lung disease through integrated bioinformatics and machine learning approaches.

BACKGROUND: Cellular senescence is a critical contributor to the pathogenesis of systemic sclerosis-associated interstitial lung disease (SSc-ILD). Ho...

Computational Evolution of Anti-PD-1 Antibodies Induces Structural Refolding for High-Affinity Interactions.

Checkpoint inhibitors targeting the PD-1/PD-L1 axis are key immunotherapies, but the dynamic and flexible nature of PD-1 complicates rational antibody...

Bioinformatics approach to identifying molecular targets of Danlou tablet against atherosclerosis: a machine learning pharmacology study.

This research aims to identify novel molecular targets and generate mechanistic hypotheses for Danlou Tablet (DLT) in the treatment of atherosclerosis...

Inhibition of the p38/JNK MAPK pathway mediated by circadian rhythm genes: Study of the mechanism of Linggan Wuwei Jiangxin decoction in the treatment of COPD.

ETHNOPHARMACOLOGICAL RELEVANCE: Chronic obstructive pulmonary disease (COPD) is a frequently encountered respiratory disease. Its clinical symptoms ar...

Development and validation of a machine learning stratified prediction model for early warning of anti-tuberculosis drug-induced liver injury risk based on real-world data: a retrospective cohort study.

OBJECTIVE: This study aimed to develop and validate stratified machine learning models for early prediction of anti-tuberculosis drug-induced liver in...

Updates on Kidney Transplantation From the World Transplant Congress 2025.

The World Transplant Congress 2025 showcased pivotal advances shaping the future of transplantation. Global efforts to expand access to transplantatio...

Machine Learning Model Development and Validation in Individuals With Suggestive Hypersensitivity to Nonsteroidal Anti-inflammatory Drugs.

BACKGROUND AND OBJECTIVES: Nonsteroidal anti-inflammatory drugs (NSAIDs) are the main triggers of drug hypersensitivity reactions (HSRs). NSAID-induce...

Unraveling the Mechanistic Spectrum of Myhre Syndrome: SMAD4 Signaling Disruption, Skeletal Phenotypes, and Translational Innovation.

Myhre syndrome (MYHRS) is an ultra-rare, progressive multisystem disorder caused by recurrent heterozygous missense variants in the SMAD4 gene, a cent...

TFAP2A transcriptionally regulates B3GALT2 to affect gouty arthritis progression through pyroptosis: a study based on machine learning and multi-omics integration analysis.

BACKGROUND: Gouty arthritis (GA) is an inflammatory joint disease driven by monosodium urate (MSU) crystal deposition. The NOD-like receptor thermal p...

Xanthine oxidase inhibitors for gout: Applications and novel drug development.

Hyperuricemia is a well-established direct trigger of gouty arthritis. Xanthine oxidase (XO), the rate-limiting enzyme in uric acid production, repres...

Development of an AI Image Recognition-Based Lateral Flow Immunochromatographic Test Strip for Higenamine Detection.

Higenamine (HM) is a naturally occurring benzylisoquinoline alkaloid found in plants and is classified as an S3 prohibited substance in the 2020 World...

Screening for Tumor Microtube-Targeting Drugs Identifies PKC Modulators as Multipotent Inhibitors of Glioblastoma Progression.

UNLABELLED: Glioblastomas are incurable primary brain tumors that depend on neural-like cellular processes, tumor microtubes (TM), to invade the brain...

Combating Antiviral Drug Resistance: A Multipronged Strategy.

ConspectusViral proteases are essential enzymes required for viral replication and assembly, making them prime antiviral drug targets. However, under ...

Intravitreal faricimab in patients with refractory diabetic macular edema: 6-month fluid analysis using artificial intelligence.

PURPOSE: Diabetic macular edema (DME) is a leading cause of vision loss in patients with diabetes. In developed countries, intravitreal (IVT) anti-vas...

The future of PCOS management: Disease modification through regenerative, metabolic, and digital therapeutics.

Polycystic ovary syndrome (PCOS) represents the leading endocrine problem affecting women of reproductive age, leading to serious complications relate...

Mechanism of action of piperine in the treatment of retinal ischemic injury based on bioinformatics and network pharmacology.

Piperine is a common anti-ischemic compound and an active ingredient of herbal medicine for various ailments. It is widely sourced and affordable. How...