Rheumatoid Arthritis

Deep learning to automatically evaluate HER2 gene amplification status from fluorescence in situ hybridization images.

Human epidermal growth factor receptor 2 (HER2) gene amplification helps identify breast cancer patients who may respond to targeted anti-HER2 therapy. This study aims to develop an automated method for quantifying HER2 fluorescence in situ hybridization (FISH) signals and improve the working efficiency of pathologists. An Aitrox artificial intelligence (AI) model based on deep learning was constr...

Anti-Synchronization of Discrete-Time Fuzzy Memristive Neural Networks via Impulse Sampled-Data Communication.

This work is concerned with the anti-synchronization (A-S) of drive-response (D-R) memristive neural networks (MNNs) based on fuzzy rules. A novel impulsive sampled-data communication mechanism is proposed by considering information security of the MNNs, in which the random response delay of sensors caused by the impulse signal is also investigated. As the state of MNNs cannot be outputted accurat...

Self-Adhesive, Anti-Freezing MXene-Based Hydrogel Strain Sensor for Motion Monitoring and Handwriting Recognition with Deep Learning.

Flexible strain sensors based on self-adhesive, high-tensile, super-sensitive conductive hydrogels have promising application in human-computer intera...

Biologically Interpretable Deep Learning To Predict Response to Immunotherapy In Advanced Melanoma Using Mutations and Copy Number Variations.

Only 30-40% of advanced melanoma patients respond effectively to immunotherapy in clinical practice, so it is necessary to accurately identify the res...

Anti-Biofilm: Machine Learning Assisted Prediction of IC Activity of Chemicals Against Biofilms of Microbes Causing Antimicrobial Resistance and Implications in Drug Repurposing.

Biofilms are one of the leading causes of antibiotic resistance. It acts as a physical barrier against the human immune system and drugs. The use of a...

Interpretable attention-based deep learning ensemble for personalized ovarian cancer treatment without manual annotations.

Inhibition of pathological angiogenesis has become one of the first FDA approved targeted therapies widely tested in anti-cancer treatment, i.e. VEGF-...

Static anti-windup compensator design for locally Lipschitz systems under input and output delays.

This paper proposes a static anti-windup compensator (AWC) design methodology for the locally Lipschitz nonlinear systems, containing time-varying int...

Artificial intelligence in communication impacts language and social relationships.

Artificial intelligence (AI) is already widely used in daily communication, but despite concerns about AI's negative effects on society the social con...

Anti-inflammatory therapy enables robot-actuated regeneration of aged muscle.

Robot-actuated mechanical loading (ML)-based therapies ("mechanotherapies") can promote regeneration after severe skeletal muscle injury, but the effe...

Advances in materials-based therapeutic strategies against osteoporosis.

Osteoporosis is caused by the disruption in homeostasis between bone formation and bone resorption. Conventional management of osteoporosis involves s...

Anti-Jamming Strategy for Federated Learning in Internet of Medical Things: A Game Approach.

Federated learning (FL) is a new dawn of artificial intelligence (AI), in which machine learning models are constructed in a distributed manner while ...

Qualitative and Artificial Intelligence-based Sentiment Analyses of Anti-LGBTI+ Hate Speech on Twitter in Turkey.

The aim of this study was to evaluate hate speech in Turkish LGBTI+-related tweets during a one-month period of artificial intelligence-based sentimen...

Lorcaserin and phentermine exert anti-obesity effects with modulation of the gut microbiota.

Although drugs have been reported to modulate the gut microbiota, the effects of anti-obesity drugs on the gut microbiota remain unclear. Lorcaserin (...

Research progress on the structure and biological diversities of 2-phenylindole derivatives in recent 20 years.

The privileged structure binds to multiple receptors with high affinity, which is helpful to the development of new bioactive compounds. Indole is cla...

Rapid simultaneous analysis of anti human immunodeficiency virus drugs in pharmaceutical formulation by smart spectrophotometry based on multivariate calibration and least squares support vector machine methods.

In this study, two chemometrics methods, including partial least squares regression (PLS) and least squares support vector machine (LS-SVM) were appli...

Integrated Damage Location Diagnosis of Frame Structure Based on Convolutional Neural Network with Inception Module.

Accurate damage location diagnosis of frame structures is of great significance to the judgment of damage degree and subsequent maintenance of frame s...

The design of compounds with desirable properties - The anti-HIV case study.

Efficacy and safety are among the most desirable characteristics of an ideal drug. The tremendous increase in computing power and the entry of artific...

Scratch-AID, a deep learning-based system for automatic detection of mouse scratching behavior with high accuracy.

Mice are the most commonly used model animals for itch research and for development of anti-itch drugs. Most laboratories manually quantify mouse scra...

GPS Spoofing Detection Method for Small UAVs Using 1D Convolution Neural Network.

The navigation of small unmanned aerial vehicles (UAVs), such as quadcopters, significantly relies on the global positioning system (GPS); however, UA...

Frame Structure Fault Diagnosis Based on a High-Precision Convolution Neural Network.

Structural health monitoring and fault diagnosis are important scientific issues in mechanical engineering, civil engineering, and other disciplines. ...