Rheumatoid Arthritis

Antioxidant, Anti-Melanogenic and Anti-Wrinkle Effects of .

In this study, the antioxidant, anti-xanthine oxidase, anti-melanogenic and anti-wrinkle effects of methanol (ME) and hot water (HE) extracts from the fruiting bodies of were investigated. The 1,1-diphenyl-2-picryl-hydrazyl free radical scavenging activity of 2.0 mg/mL HE (95.38%) was comparable to that of butylated hydroxytoluene (96.97%), the reference standard. The hydroxyl radical scavenging ...

Serum lactoferrin concentration of primiparous sow during gestation and lactation, and comparison between sow-fed and formula-fed piglets.

Lactoferrin (LF) is a sialylated iron-binding glycoprotein, occurring in several biological secretions like milk, saliva, and seminal fluids and is a major component of a mammalian innate immune system. It plays multiple protective roles against large group of microorganisms and performs anti-inflammatory and anti-cancer activities. The concentration of serum LF in gilt (primiparous sow) and their...

Novel small molecule retrograde transport blocker confers post-exposure protection against ricin intoxication.

Ricin is a highly toxic type 2 ribosome-inactivating protein (RIP) which is extracted from the seeds of castor beans. Ricin is considered a potential ...

Strategies to Tackle the Global Burden of Diabetic Retinopathy: From Epidemiology to Artificial Intelligence.

Diabetes is a global public health disease projected to affect 642 million adults by 2040, with about 75% residing in low- and middle-income countries...

Alkaline conditions better extract anti-inflammatory polysaccharides from winemaking by-products.

Winemaking generates large amounts of by-products, a well recognized source of phenolic compounds. However, less attention has been paid to the polysa...

HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.

Recent data indicate that up-to 30-40% of cancers can be prevented by dietary and lifestyle measures alone. Herein, we introduce a unique network-base...

Sorghum Fermented by NK Enhances Inhibition of Vascular Inflammation in TNF-α-stimulated Human Aortic Smooth Muscle Cells.

Sorghum bicolor L. Moench is widely grown all over the world for food and feed. The effects of sorghum extracts on general inflammation have been pr...

A new M23-based ELISA assay for anti-aquaporin 4 autoantibodies: diagnostic accuracy and clinical correlation.

PURPOSE: Although many assays have been developed to detect anti-aquaporin-4 (AQP4) antibodies, most of these assays require sophisticated techniques ...

Quantitative Structure-Activity Relationships for Structurally Diverse Chemotypes Having Anti- Activity.

Small-molecule compounds that have promising activity against macromolecular targets from occasionally fail when tested in whole-cell phenotypic assa...

Pre-Treatment Biomarkers of Anti-Tumour Necrosis Factor Therapy Response in Crohn's Disease-A Systematic Review and Gene Ontology Analysis.

The most prominent treatment for the serious cases of Crohn's disease (CD) are biological tumour necrosis factor (TNF) inhibitors. Unfortunately, ther...

Anti-Synchronization in Fixed Time for Discontinuous Reaction-Diffusion Neural Networks With Time-Varying Coefficients and Time Delay.

This paper studies the fixed-time anti-synchronization (FTAS) of discontinuous reaction-diffusion neural networks (DRDNNs) with both time-varying coef...

Machine Learning Methods to Predict Social Media Disaster Rumor Refuters.

This research provides a general methodology for distinguishing disaster-related anti-rumor spreaders from a non-ignorant population base, with strong...

Acute renal failure in systemic sclerosis revealing Goodpasture syndrome: "All that glitters is not scleroderma renal crisis".

The most common cause of acute renal failure in systemic sclerosis patients is scleroderma renal crisis but other etiologies have to be considered suc...

Quantification of apixaban in human plasma using ultra performance liquid chromatography coupled with tandem mass spectrometry.

Apixaban, an inhibitor of direct factor Xa, is used for the treatment of venous thromboembolic events or prevention of stroke. Unlike many other antic...

Reinforcement learning-based control of tumor growth under anti-angiogenic therapy.

BACKGROUND AND OBJECTIVES: In recent decades, cancer has become one of the most fatal and destructive diseases which is threatening humans life. Accor...

PPI-Detect: A support vector machine model for sequence-based prediction of protein-protein interactions.

The prediction of peptide-protein or protein-protein interactions (PPI) is a challenging task, especially if amino acid sequences are the only informa...

Hydroxytyrosol: The Phytochemical Responsible for Bioactivity of Traditionally used Olive Pits.

The fruits of L. is widely consumed as food, and olive pits are utilized in folk medicine to relieve gastric disturbances. In the present study, the ...

Synthesis of chitosan nanoparticles, chitosan-bulk, chitosan nanoparticles conjugated with glutaraldehyde with strong anti-cancer proliferative capabilities.

In recent years, natural and synthetic polymers have attracted much attention due to their great potentials in medical science. In the present study, ...

Synthesis, characterization, antimicrobial and antimetastatic activity of silver nanoparticles synthesized from Ficus ingens leaf.

Cancer incidence is still increasing due to inadequate responsive treatments. Inertness and biocompatibility of nanoparticles synthesized using plant ...

Anti-tumorigenic and Platinum-Sensitizing Effects of Apolipoprotein A1 and Apolipoprotein A1 Mimetic Peptides in Ovarian Cancer.

Apolipoprotein A1 (ApoA1) is remarkably decreased in serum and ovarian tissues of ovarian cancer patients. ApoA1 and ApoA1 mimetic peptides can seque...