Rheumatology

Latest AI and machine learning research in rheumatology for healthcare professionals.

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A Scoping Review of Machine Learning Applications for Diagnosis, Classification, and Prognosis in Lupus Nephritis.

BACKGROUND: Over the past decade, machine learning (ML) has transformed histopathology, yet its application in lupus nephritis (LN) remains underexplored. Earlier reviews have centered on pathologist concordance in LN classification, biomarkers, and AI-enabled diagnosis and treatment-response prediction. Here, we conducted the first comprehensive scoping review of ML in LN, spanning across diagnos...

Mar 18 2026 41848794

Detection of sample swapping in anti-doping investigations using machine learning.

The substitution of a urine sample that may result in an adverse analytical finding with a previously collected, clean sample is strictly prohibited under the World Anti-Doping Agency (WADA) regulations and is referred to as sample swapping. When an athlete reuses their own clean sample, detection becomes particularly difficult through conventional analytical methods. In this paper, we propose a s...

Mar 17 2026 41844716
Immune checkpoint molecules beyond PD-1 and CTLA-4: emerging targets in autoimmune diseases and cancer immunotherapy.

BACKGROUND: Immune checkpoint molecules are pivotal regulators of immune activation and tolerance, playing critical roles in cancer, autoimmunity, inf...

Mar 17 2026 41842954
Ultrasonic-assisted extraction, purification, identification, and bioactivity evaluation of phlorotannins from Sargassum fusiforme: A comparative study of RSM and SVM-GA.

Sargassum fusiforme is a medicinal and edible species present in China, Korea, and Japan, and its phlorotannins are considered valuable bioactive comp...

Mar 16 2026 41863963
Self-organizing neural network-based generative AI with embedded error inflation control enhances effective knowledge extraction from preclinical studies with reduced sample size.

Small sample sizes in preclinical research limit the extraction of reliable knowledge and hinder translational progress. We propose genESOM, a generat...

Mar 13 2026 41833766
Infrared thermography in the detection of arthritis: a systematic review of diagnostic performance compared with joint ultrasound.

Early detection of arthritis in autoimmune rheumatic diseases (ARDs) is critical to prevent irreversible damage. Joint ultrasound (US) offers high sen...

Mar 12 2026 41817825
DeepStackVEGF a stacking ensemble deep learning framework for vascular endothelial growth factor prediction.

Vascular Endothelial Growth Factor (VEGF) plays a central role in angiogenesis, regulating both physiological processes such as wound healing, tissue ...

Mar 11 2026 41807480
Machine learning-based prediction model for fall risk among individuals with arthritis in China: an analysis using the China Health and Retirement Longitudinal Study (CHARLS) database.

BACKGROUND: Falling has become a global public health problem. Individuals with arthritis have a higher risk of falling because of joint pain, poor mu...

Mar 10 2026 41808237
Use of synthetic data, a novel paradigm for immunopathology.

The complexity and heterogeneity of autoimmune diseases are only partially captured by current analytic tools, even when deep learning techniques are ...

Mar 10 2026 41812346
Assessment of quantum chemical predictors for anti-colorectal cancer agents using QSAR modeling.

Optimizing the prediction of anti-colorectal cancer agent activity is essential aspect in the identification and creation of medications. Machine lear...

Mar 10 2026 41803390
[Plasma proteomics in age-related macular degeneration].

BACKGROUND: Neovascular age-related macular degeneration (nAMD) shows a heterogeneous treatment response to anti-vascular endothelial growth factor (V...

Mar 10 2026 41805864
Bridging Population Patterns and Individual Prediction: Framework for Prospective Multimorbidity Study.

BACKGROUND: Multimorbidity has become a major global public health challenge. However, existing research primarily emphasizes the identification of di...

Mar 10 2026 41806366
Precision immunotherapies for systemic lupus erythematosus: From pathogenic targets to translational horizons.

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disorder in which aberrant B-cell activation, persistent autoantibody production, and...

Mar 9 2026 41812738
Generative Artificial Intelligence Tools: Evaluating Ways to Automate Your SALT (GATEWAYS) Scoring of Alopecia Areata.

BACKGROUND: Alopecia areata (AA) is an autoimmune disease affecting hair follicles that results in nonscarring hair loss. AA impacts 0.1%-0.2% of the ...

Mar 9 2026 41802724
Pharmacokinetic modeling to optimize development and therapeutic potential of mAb-based therapies.

Monoclonal antibody (mAb)-based therapies have revolutionized modern medicine, offering highly specific and effective treatments for a wide range of d...

Mar 6 2026 41796750
Development of a Classifier for Metabolic Subtypes of Nasopharyngeal Carcinoma to Guide Personalized Immunotherapy Strategies: Biomarker Analysis of the Phase III CONTINUUM and DIPPER Trials.

PURPOSE: Personalized immunotherapy strategies are urgently needed for patients with locoregionally advanced nasopharyngeal carcinoma (NPC). We aim to...

Mar 6 2026 41791006
Predicting VRE Infection After Liver Transplantation With a Time-Updated Colonization Score.

BACKGROUND: Vancomycin-resistant Enterococcus (VRE) infection is a life-threatening complication after liver transplantation (LT). This study aimed to...

Mar 6 2026 41792590
An algorithm for automated femoral leg length and offset calculations on pelvis radiographs.

INTRODUCTION: Manual measurement of leg length (LL) and offset can be tedious. This study developed an automated algorithm for measuring LL and offset...

Mar 5 2026 41786668
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