Rheumatology

OCT-based deep learning algorithm for the evaluation of treatment indication with anti-vascular endothelial growth factor medications.

PURPOSE: Intravitreal injections with anti-vascular endothelial growth factor (anti-VEGF) medications have become the standard of care for their respective indications. Optical coherence tomography (OCT) scans of the central retina provide detailed anatomical data and are widely used by clinicians in the decision-making process of anti-VEGF indication. In recent years, significant progress has bee...

Novel T-C@AgNPs mediated biocidal mechanism against biofilm associated methicillin-resistant (Bap-MRSA) 090, cytotoxicity and its molecular docking studies.

is a commonly found pathogen that can cause food-spoilage and life threatening infections. However, the potential molecular effects of natural active thymol molecules and chitosan silver nanoparticles (C@AgNPs) in bacteria remain unclear. This gap in the literature has prompted us to study the effects of thymol loaded chitosan silver nanoparticles (T-C@AgNPs) against biofilm associated proteins i...

Lupus pneumonitis presenting with high titre of anti-Ro antibody.

Lupus pneumonitis carries high mortality and is a rare manifestation of systemic lupus erythematosus (SLE). However, it is difficult to diagnose and i...

Co-stimulation of the fc receptor and interleukin-12 receptor on human natural killer cells leads to increased expression of cd25.

Natural killer (NK) cells serve a critical role in the immune response against microbes and developing tumors. We have demonstrated that NK cells prod...

Upgrade Combination Response Is Limited by Prolonged Nucelos(t)ide Analogue Therapy in HBeAg-positive Chronic Hepatitis B: A Real-life Study.

Few previous studies have reported on a combination response (hepatitis B virus (HBV) DNA undetected, alanine aminotransferase normalization and hepa...

Anti- Effects of Methanol Extracts of , and .

OBJECTIVES: The currently available agents for use against toxoplasmosis have serious limitations. Thus, the aim of the present study was to investiga...

Interstitial inflammation and interstitial fibrosis and tubular atrophy predict renal survival in lupus nephritis.

BACKGROUND: This study examines the effect of interstitial inflammation and interstitial fibrosis and tubular atrophy on renal survival in lupus nephr...

Clopidogrel-Induced Insulin Autoimmune Syndrome: A Newly Recognized Cause of Hypoglycemia in a Patient Without Diabetes.

Insulin autoimmune syndrome (IAS), defined as hyperinsulinemic hypoglycemia with high titers of anti-insulin antibodies, is frequently reported in Jap...

Word2Vec inversion and traditional text classifiers for phenotyping lupus.

BACKGROUND: Identifying patients with certain clinical criteria based on manual chart review of doctors' notes is a daunting task given the massive am...

Antioxidant and xanthine oxidase inhibitory activities of total polyphenols from onion.

Onions ( L.) comprise a valuable vegetable crop in many countries. Modern scientific research has shown that onions possess many biological activities...

Effects of Oleo Gum Resin of L. on Senescence in Human Dermal Fibroblasts: - Asafoetida reverses senescence in fibroblasts.

OBJECTIVES: Based on data from Chinese and Indian traditional herbal medicines, gum resin of (sometimes referred to asafetida or asafoetida) has seve...

Identification of non-activated lymphocytes using three-dimensional refractive index tomography and machine learning.

Identification of lymphocyte cell types are crucial for understanding their pathophysiological roles in human diseases. Current methods for discrimina...

Antiphospholipid Antibodies and Heart Valve Disease in Systemic Lupus Erythematosus.

Evaluation of antiphospholipid antibodies (aPL) and correlation with heart valve abnormalities among patients with systemic lupus erythematosus (SLE)....

Virtual-screening workflow tutorials and prospective results from the Teach-Discover-Treat competition 2014 against malaria.

The first challenge in the 2014 competition launched by the Teach-Discover-Treat (TDT) initiative asked for the development of a tutorial for ligand-b...

Data mining and pathway analysis of glucose-6-phosphate dehydrogenase with natural language processing.

Human glucose-6-phosphate dehydrogenase (G6PD) is a crucial enzyme in the pentose phosphate pathway, and serves an important role in biosynthesis and ...

Evaluating the impact of vitreomacular adhesion on anti-VEGF therapy for retinal vein occlusion using machine learning.

Vitreomacular adhesion (VMA) represents a prognostic biomarker in the management of exudative macular disease using anti-vascular endothelial growth f...

Beta-2 Microglobulin in Whole Unstimulated Saliva Can Effectively Distinguish Between Sjögren's Syndrome and Non-Autoimmune Sicca Symptoms.

OBJECTIVES: This study aims to describe salivary beta-2 microglobulin (sB2M) levels in our setting and to assess the performance of sB2M for the diagn...

Performance of Machine Learning Algorithms for Qualitative and Quantitative Prediction Drug Blockade of hERG1 channel.

Drug-induced abnormal heart rhythm known as (TdP) is a potential lethal ventricular tachycardia found in many patients. Even newly released anti-arrh...

Hepatitis B reactivation in psoriasis patients treated with anti-TNF agents: prevention and management.

The risk of hepatitis B virus (HBV) reactivation (HBVr) in chronic HBV carriers, in occult HBV patients or in acute HBV patients affected by psoriasis...

Evaluation of the Ph. Eur. anti-A and anti-B assay on a pipetting robot in combination with a camera guided reading mode.

The main objective of this study was the standardization of the direct anti-A, anti-B haemagglutination assay for immunoglobulin products in microtitr...