Rheumatology

Multidimensional analysis of tumour immune microenvironment in HCC: prognostic significance and implications for immunotherapy.

BACKGROUND: The combination of immune checkpoint inhibitors (ICIs) and anti-angiogenic agents represents the standard first-line therapy for patients with unresectable hepatocellular carcinoma (HCC). However, most patients do not derive sustained clinical benefit. Emerging evidence has underscored a strong association between immunotherapy efficacy and the tumor immune microenvironment (TIME) in H...

Research progress on debridement, antibiotics, and implant retention (DAIR) for the treatment of periprosthetic joint infection after artificial joint replacement.

Periprosthetic joint infection (PJI) is one of the most serious complications following artificial joint replacement, posing significant treatment challenges and a heavy clinical burden. Debridement, antibiotics, and implant retention (DAIR) has become the preferred treatment strategy for acute PJI due to its advantages of minimal invasiveness, functional preservation, and cost-effectiveness. This...

Shiyiwei Shenqi Pian-derived quercetin reactivates apoptosis in clear cell renal cell carcinoma by destabilizing survivin and x-linked inhibitor of apoptosis protein.

BACKGROUND: Clear cell renal cell carcinoma (ccRCC) strongly resists apoptosis via baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5) and ...

Dihydroberberine regulates the ferroptosis-autophagy positive feedback loop in colorectal cancer by targeting PANX2.

BACKGROUND: Colorectal cancer (CRC) is one of the most common malignancies worldwide and remains a major clinical challenge, underscoring the urgent n...

Early prediction of joint space narrowing in rheumatoid arthritis using AI-quantified bilateral joint space asymmetry on hand radiography.

PURPOSE: Joint space narrowing (JSN) in rheumatoid arthritis (RA) can progress even during clinical remission. Conventional imaging lacks sensitivity ...

Psoriatic Disease Across Dimensions: Global Epidemiology, Comorbidity, and Artificial Intelligence in Treatment Prediction.

The Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) 2025 annual meeting featured a new "Soapbox: Rapid fire presentati...

Review of the SWIR Windows to Study Osteoarthritis.

Due to minimal absorption and scattering, light at select wavelengths in the short wavelength infrared (SWIR: 1000-2500 nm) region can be utilized for...

Machine learning reveals X chromosome transcriptional signatures that classify systemic lupus erythematosus in females.

BACKGROUND: Systemic lupus erythematosus (SLE) has a significant female bias; however, it remains unclear whether X-chromosomal dysregulation increase...

Multi-omics Signature Predicts Anti-EGFR Therapy Benefit in Colorectal Cancer Liver Metastases: A Multi-center Cohort Study.

INTRODUCTION: Clinical management of RAS wild-type colorectal cancer liver metastases (CRLM) remains challenging because many patients exhibit primary...

Discovery of biomarkers for primary Sj ögren's syndrome based on multi-omics data, construction of diagnostic models, and clinical correlation analysis.

OBJECTIVE: Primary Sjogren's syndrome(pSS) exhibits significant clinical heterogeneity, which poses challenges for accurately assessing disease activi...

Real-world integration of an autonomous artificial intelligence system for diabetic retinopathy screening in an endocrinology outpatient clinic.

AIM: To evaluate a real-world clinical integration of an autonomous artificial intelligence (AI) system (AEYE Diagnostic Screening (AEYE-DS), AEYE Hea...

The influence of anti-involution training on the critical thinking of young healthcare professionals in dental outpatient clinics: a pre-post quasi-experimental study.

BACKGROUND: This study evaluates changes in critical thinking among dental healthcare workers after anti-involution training (AIT) and identifies key ...

Dominance, drivers and thresholds of DEN, ANA, and DNRA quantified using a global dataset of cross-ecosystems and machine-learning.

Nitrogen retention and loss in the critical zone are regulated by denitrification (DEN), anaerobic ammonium oxidation (ANA) and dissimilatory nitrate ...

A mechanism-guided framework for prioritizing membrane-interaction anti-Vibrio peptides from peptidomics data.

A mechanism-guided framework for prioritizing membrane-interaction antimicrobial peptide candidates from proteomics-derived peptide mixtures is presen...

Integrative analysis of machine learning and single-cell sequencing identifies IGHG1 as a therapeutic target for epimedium in diabetes-gastric cancer comorbidity.

BACKGROUND: The clinical comorbidity of diabetes mellitus (DM) and gastric cancer (GC) presents a significant healthcare challenge, as these two condi...

Universal deep learning strategy leveraging peptide atomic 3D structural information identifies diverse bioactive peptides from wheat germ protein hydrolysates.

Existing deep learning strategies for identifying bioactive peptides (BAPs) are often limited by single-task models and shallow sequence-based feature...

[Deep learning-driven high-frequency ultrasound method for skin aging assessment].

Ultraviolet radiation is a primary external factor contributing to skin photoaging, as it induces cellular deoxyribonucleic acid damage and collagen d...

Development of a LASSO-based machine learning model for relapse prediction in lupus nephritis.

OBJECTIVE: To identify the predictors of renal relapse in patients with lupus nephritis (LN) and develop a predictive model. METHODS: The patients wit...

Identification of a 10-protein plasma signature for preclinical gout risk beyond serum urate: a robustness-first proteomic study in 33,147 normouricaemic individuals.

BACKGROUND: Gout risk assessment is currently reactive, relying on hyperuricaemia. However, a significant clinical gap exists for individuals who deve...

Identification of Diagnostic Biomarkers Among Metabolism-related Genes in Rheumatoid Arthritis: Insights into Immune Landscape and Molecular Subtype Characterization.

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation and joint destruction. Metabolic reprogramming and im...