Rheumatology

First nomogram for predicting interstitial lung disease and pulmonary arterial hypertension in SLE: a machine learning approach.

BACKGROUND: Interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH) are severe, life-threatening complications of systemic lupus erythematosus (SLE). Early identification of high-risk patients remains challenging due to the lack of validated predictive tools. We aimed to develop and validate the first machine learning-based nomogram integrating routine clinical indicators to pred...

A Digital Score Based on Circulating-Tumor-Cells-Derived mRNA Quantification and Machine Learning for Early Colorectal Cancer Detection.

Circulating tumor cells (CTCs) serve as valuable biomarkers in tumor circulation, carrying essential primary tumor information. The purification of CTCs from peripheral blood samples and the analysis of their characteristic molecules enable the detection of tumors at an early stage. The noninvasive, continuous, real-time dynamic monitoring provides a promising solution for the timely diagnosis of ...

Anti-Inpainting: A Proactive Defense against Malicious Diffusion-based Inpainters under Unknown Conditions

As diffusion-based malicious image manipulation becomes increasingly prevalent, multiple proactive defense methods are developed to safeguard images...

Similarity of immune-associated markers in COVID-19 and Kawasaki disease: analyses from bioinformatics and machine learning.

BACKGROUND: Infection by the SARS-CoV-2 virus can cause coronavirus disease 2019 (COVID-19) and can also exacerbate the symptoms of Kawasaki disease (...

Deep transfer learning approach for automated cell death classification reveals novel ferroptosis-inducing agents in subsets of B-ALL.

Ferroptosis is a recently described type of regulated necrotic cell death whose induction has anti-cancer therapeutic potential, especially in hematol...

Anti-Sensing: Defense against Unauthorized Radar-based Human Vital Sign Sensing with Physically Realizable Wearable Oscillators

Recent advancements in Ultra-Wideband (UWB) radar technology have enabled contactless, non-line-of-sight vital sign monitoring, making it a valuable...

Optimal normalization in quantum-classical hybrid models for anti-cancer drug response prediction

Quantum-classical Hybrid Machine Learning (QHML) models are recognized for their robust performance and high generalization ability even for relativ...

Forecasting Banned Substances: Leveraging GNN and Explainable AI for Sports Anti-Doping.

Ensuring fairness in competitive sports requires robust mechanisms for detecting prohibited substances. Despite established regulations, challenges pe...

A Multitask Network for the Diagnosis of Autoimmune Gastritis.

Autoimmune gastritis (AIG) has a strong correlation with gastric neuroendocrine tumors (NETs) and gastric cancer, making its timely and accurate diagn...

FaceShield: Explainable Face Anti-Spoofing with Multimodal Large Language Models

Face anti-spoofing (FAS) is crucial for protecting facial recognition systems from presentation attacks. Previous methods approached this task as a ...

scPrediXcan integrates deep learning methods and single-cell data into a cell-type-specific transcriptome-wide association study framework.

Transcriptome-wide association studies (TWASs) help identify disease-causing genes but often fail to pinpoint disease mechanisms at the cellular level...

Redefining Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer in the Era of Novel Antibody-Drug Conjugates.

The advent of next-generation antibody-drug conjugates (ADCs), particularly trastuzumab deruxtecan (T-DXd), has transformed our understanding of human...

Targeting high-risk multiple myeloma genotypes with optimized anti-CD70 CAR-T cells.

Despite the success of BCMA-targeting CAR-Ts in multiple myeloma, patients with high-risk cytogenetic features still relapse most quickly and are in u...

Single-cell and spatial transcriptomics reveals an anti-tumor neutrophil subgroup in microwave thermochemotherapy-treated lip cancer.

Microwave thermochemotherapy (MTC) has been applied to treat lip squamous cell carcinoma (LSCC), but a deeper understanding of its therapeutic mechani...

Enhancing PI3Kγ inhibitor discovery: a machine learning-based virtual screening approach integrating pharmacophores, docking, and molecular descriptors.

PI3Kγ is a lipid kinase that is expressed primarily in leukocytes and plays a significant role in tumors, inflammation, and autoimmune diseases. Conse...

Discrimination of Normal from Slow-Aging Mice by Plasma Metabolomic and Proteomic Features.

Tests that can predict whether a drug is likely to extend mouse lifespan could speed up the search for anti-aging drugs. We have applied a machine lea...

A Multichannel Continuum Robot for Diagnosis and Treatment of Vascular Lesions.

In recent years, continuum soft robots have emerged as a promising avenue for the advancement of therapeutic interventions. However, the current cont...

Developing a Machine-Learning Prediction Model for Infliximab Response in Crohn's Disease: Integrating Clinical Characteristics and Longitudinal Laboratory Trends.

BACKGROUND: Achieving long-term clinical remission in Crohn's disease (CD) with antitumor necrosis factor α (anti-TNF-α) agents remains challenging.

AI-Driven Analysis Unveils Functional Dynamics of Müller Cells in Retinal Autoimmune Inflammation.

Müllercell is the most common type of glial cell in the human and mouse retina, playing a crucial role in maintaining retinal homeostasis. In addition...

Biological markers and psychosocial factors predict chronic pain conditions.

Chronic pain is a multifactorial condition presenting significant diagnostic and prognostic challenges. Biomarkers for the classification and the pred...