Rheumatology

Latest AI and machine learning research in rheumatology for healthcare professionals.

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PD-1 Targeted Antibody Discovery Using AI Protein Diffusion.

The programmed cell death protein 1 (PD-1, CD279) is an important therapeutic target in many oncological diseases. This checkpoint protein inhibits T lymphocytes from attacking other cells in the body and thus blocking it improves the clearance of tumor cells by the immune system. While there are already multiple FDA-approved anti-PD-1 antibodies, including nivolumab ( from Bristol-Myers Squibb) a...

Jan 1 2024 39228166
Artificial Intelligence Application for Anti-tumor Drug Synergy Prediction.

Currently, the main therapeutic methods for cancer include surgery, radiation therapy, and chemotherapy. However, chemotherapy still plays an importan...

Jan 1 2024 39420717
USING ARTIFICIAL INTELLIGENCE AND MACHINE LEARNING APPROACHES TO ENHANCE CANCER THERAPY AND DRUG DISCOVERY: A NARRATIVE REVIEW.

BACKGROUND: This paper looks at how AI and machine learning have been applied over the last ten years to the development of anti-cancer drugs. By spee...

Jan 1 2024 39585283
IgE anti-BP180 NC16A autoantibody in both serum and blister fluid samples does not correlate with disease activity of bullous pemphigoid.

The correlation between IgE anti-BP180 NC16A autoantibody and disease activity of bullous pemphigoid (BP) remains disputable. To determine the levels ...

Dec 1 2023 38465539
[Experimental study of APB-DOCK8 transgenic tomato vaccine for caries prevention].

PURPOSE: To observe the anti-caries effect of transgenic tomato anti-caries vaccine after immunization with SD rats by gavage and to explore its immun...

Dec 1 2023 38494961
Skin Changes in Suspected Lyme Disease.

Dear Editor, Ticks carry many diseases, bacteria, and viruses and represent a very important healthcare issue both in Croatia and globally. Although m...

Dec 1 2023 38651851
Visual analysis of autoimmune dry eye studies based on bibliometrics.

BACKGROUND: Dry eye is a chronic ocular surface disease caused by the instability of tear film or the imbalance of the ocular surface microenvironment...

Nov 24 2023 38013305
Moringa oleifera-mediated iron oxide nanoparticles, characterization and their anti-proliferative potential on MDA-MB 231 human breast cancer cells.

Iron oxide nanoparticles (FeO NPs) stabilized with Moringa oleifera (M.O.) were successfully synthesized. The study aimed to explore the cytotoxic, an...

Nov 1 2023 38264893
[Not Available].

Advancing our understanding of complex diseases necessitates an interdisciplinary dialogue beyond artificial intelligence (AI) in the field of medicin...

Sep 1 2023 37529990
Musculoskeletal CT Imaging: State-of-the-Art Advancements and Future Directions.

CT is one of the most widely used modalities for musculoskeletal imaging. Recent advancements in the field include the introduction of four-dimensiona...

Aug 1 2023 37606571
DETERMINATION OF THE PRA POSITIVITY PERCENTAGE IN MALE PATIENTS WITH CHRONIC KIDNEY DISEASE BY USING FLOW CYTOMETRY TECHNIQUE.

The antibodies directed against human leukocyte antigen (HLA) molecules, which play a crucial role in allograft histocompatibility, are called anti-HL...

Aug 1 2023 38549598
DDMut: predicting effects of mutations on protein stability using deep learning.

Understanding the effects of mutations on protein stability is crucial for variant interpretation and prioritisation, protein engineering, and biotech...

Jul 5 2023 37283042
A deep learning system for quantitative assessment of microvascular abnormalities in nailfold capillary images.

OBJECTIVES: Nailfold capillaroscopy is key to timely diagnosis of SSc, but is often not used in rheumatology clinics because the images are difficult ...

Jun 1 2023 36651676
AcrNET: predicting anti-CRISPR with deep learning.

MOTIVATION: As an important group of proteins discovered in phages, anti-CRISPR inhibits the activity of the immune system of bacteria (i.e. CRISPR-Ca...

May 4 2023 37084259
AgeAnno: a knowledgebase of single-cell annotation of aging in human.

Aging is a complex process that accompanied by molecular and cellular alterations. The identification of tissue-/cell type-specific biomarkers of agin...

Jan 6 2023 36200838
Exploring Anti-osteoporosis Medicinal Herbs using Cheminformatics and Deep Learning Approaches.

BACKGROUND: Osteoporosis is a prevalent disease for the aged population. Chinese herbderived natural compounds have anti-osteoporosis effects. Due to ...

Jan 1 2023 36065918
Prescreening in oncology trials using medical records. Natural language processing applied on lung cancer multidisciplinary team meeting reports.

Defining profiles of patients that could benefit from relevant anti-cancer treatments is essential. An increasing number of specific criteria are nece...

Jan 1 2023 36964666
In Vitro Antiviral Activity of a New Indol-3-carboxylic Acid Derivative Against SARS-CoV-2.

The coronavirus disease (COVID-19) pandemic has brought into sharp relief the threat posed by coronaviruses and laid the foundation for a fundamental ...

Jan 1 2023 38234608
First Case Report Of Anca-Associated Vasculitis And Anthracosis Coexistence.

Anthracosis is a type of mild pneumoconiosis secondary to harmless carbon dust deposits. Although anthracosis was previously associated with inhaled c...

Jan 1 2023 38404098
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