Rheumatology

iMFP-LG: Identify Novel Multi-functional Peptides Using Protein Language Models and Graph-based Deep Learning.

Functional peptides are short amino acid fragments that have a wide range of beneficial functions for living organisms. The majority of previous studies have focused on mono-functional peptides, but an increasing number of multi-functional peptides have been discovered. Although there have been enormous experimental efforts to assay multi-functional peptides, only a small portion of millions of kn...

COX-2 Inhibitor Prediction With KNIME: A Codeless Automated Machine Learning-Based Virtual Screening Workflow.

Cyclooxygenase-2 (COX-2) is an enzyme that plays a crucial role in inflammation by converting arachidonic acid into prostaglandins. The overexpression of enzyme is associated with conditions such as cancer, arthritis, and Alzheimer's disease (AD), where it contributes to neuroinflammation. In silico virtual screening is pivotal in early-stage drug discovery; however, the absence of coding or machi...

A data-driven approach to discover and quantify systemic lupus erythematosus etiological heterogeneity from electronic health records

Systemic lupus erythematosus (SLE) is a complex heterogeneous disease with many manifestational facets. We propose a data-driven approach to discove...

DivTrackee versus DynTracker: Promoting Diversity in Anti-Facial Recognition against Dynamic FR Strategy

The widespread adoption of facial recognition (FR) models raises serious concerns about their potential misuse, motivating the development of anti-f...

Guiding Treatment Strategies: The Role of Adjuvant Anti-Her2 Neu Therapy and Skin/Nipple Involvement in Local Recurrence-Free Survival in Breast Cancer Patients

This study explores how causal inference models, specifically the Linear Non-Gaussian Acyclic Model (LiNGAM), can extract causal relationships betwe...

Asynchronous Hebbian/anti-Hebbian networks

Lateral inhibition models coupled with Hebbian plasticity have been shown to learn factorised causal representations of input stimuli, for instance,...

Interpretable Face Anti-Spoofing: Enhancing Generalization with Multimodal Large Language Models

Face Anti-Spoofing (FAS) is essential for ensuring the security and reliability of facial recognition systems. Most existing FAS methods are formula...

ACE: Anti-Editing Concept Erasure in Text-to-Image Models

Recent advance in text-to-image diffusion models have significantly facilitated the generation of high-quality images, but also raising concerns abo...

Machine-Learning-Assisted Exploration of High Entropy-Atom Nanozyme for Anti-Tumor Immunotherapy by Enhancing Enzyme Activity and Disrupting Dual Energy Metabolism

Despite its potential in cancer therapy, single-atom nanozyme (SAzyme) faces challenges like low atomic loading and rapid cancer metabolism. Here, a h...

Multivariate pattern analysis reveals resting-state EEG biomarkers in fibromyalgia

Fibromyalgia (FM) involves widespread musculoskeletal pain and hypersensitivity, often accompanied by neurological, cognitive, and affective disturban...

Semi-supervised detection of natural selection with positive-unlabeled learning

Identifying genomic regions shaped by natural selection is a central goal in evolutionary ge-nomics. Existing machine learning methods for this task a...

Cerebral Organoids Uncover Mechanisms of Neural Activity Changes in Epileptogenesis

Neurological disorders often originate from progressive brain network dysfunctions that start years before symptoms appear. How these changes emerge i...

Influ-BERT: A Domain-Adaptive Genomic Language Model for Advancing Influenza A Virus Research

Influenza A Virus (IAV) poses a persistent threat to global public health due to its broad host adaptability, frequent anti-genic variation, and poten...

Ultrastructural Analysis of Human Uncinate Fasciculus with Spectral-Focusing Coherent Anti-Stokes Raman Spectroscopy

Characterizing the ultrastructure of myelin in the human brain is key to understanding the neurobiology of both health and disease. In postmortem huma...

PRESTIGE-ST: Patch Resolution and Encoder STrategies for Inference of Gene Expression from Spatial Transcriptomics

Spatial Transcriptomics (ST) integrates histology with spatially resolved gene expression, offering rich insights into tissue architecture and functio...

A deep learning approach for rational affinity maturation of anti-VEGF nanobodies

Nanobodies offer several advantages over conventional antibodies due to their lower immunogenicity, enhanced stability, and superior tissue penetratio...

Accuracy and Scalability of Machine Learning Methods for Genotype-Phenotype Association Data

Many machine learning methods can be applied to predicting phenotypes from genetic data. Which of these methods work best remains an open question, ho...

Screening of Oyster Peptides for Anti-Muscle Atrophy Based on Machine Learning and Computer Simulation: Guided by Antioxidant Pathways

Muscle atrophy poses a serious threat to human health, with its primary pathogenic mechanisms closely linked to oxidative stress. This study focuses o...

Integrated analysis implicates novel insights of NMB into lactate metabolism and immune response prediction in primary glioblastoma

Glioblastoma (GBM), the most aggressive primary brain tumor in adults, exhibits profound treatment resistance and poor prognosis. Despite advances in ...

A validated set of neural gene reporter mice and chemical tracers tools for mapping knee innervating neurons

Joint pain is an increasing concern for our aging population, as current therapies to slow joint disease progression or reduce pain are largely ineffe...