Hospital-Based Medicine

Risk Management

Latest AI and machine learning research in risk management for healthcare professionals.

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A protocol for evaluating robustness to H&E staining variation in computational pathology models

Sensitivity to staining variation remains a major barrier to deploying computational pathology (CPath) models as hematoxylin and eosin (H&E) staining varies across laboratories, requiring systematic assessment of how this variability affects model prediction. In this work, we developed a three-step protocol for evaluating robustness to H&E staining variation in CPath models. Step 1: Select referen...

Mar 13 2026 2603.12886v1

A Standardized Framework For Evaluating Gene Expression Generative Models

The rapid development of generative models for single-cell gene expression data has created an urgent need for standardised evaluation frameworks. Current evaluation practices suffer from inconsistent metric implementations, incomparable hyperparameter choices, and a lack of biologically-grounded metrics. We present Generated Genetic Expression Evaluator (GGE), an open-source Python framework that...

Mar 11 2026 2603.11244v1
Automated extraction and optimization of protein purification protocols using multi-agent large language models

Recent advances in Large Language Models (LLMs) present new opportunities for automating critical bottlenecks in scientific workflows such as literatu...

A dataset of medication images with instance segmentation masks for preventing adverse drug events

Medication errors and adverse drug events (ADEs) pose significant risks to patient safety, often arising from difficulties in reliably identifying pha...

Mar 11 2026 2603.10825v1
SwiftTCR: Efficient Computational Docking protocol of TCRpMHC-I Complexes Using Restricted Rotation Matrices

The T cell's ability to discern self and non-self depends on its T cell receptor (TCR), which recognizes peptides presented by MHC molecules. Understa...

From Days to Minutes: An Autonomous AI Agent Achieves Reliable Clinical Triage in Remote Patient Monitoring

Background: Remote patient monitoring (RPM) generates vast data, yet landmark trials (Tele-HF, BEAT-HF) failed because data volume overwhelmed clinica...

Mar 10 2026 2603.09052v1
ICDAR 2025 Competition on End-to-End Document Image Machine Translation Towards Complex Layouts

Document Image Machine Translation (DIMT) seeks to translate text embedded in document images from one language to another by jointly modeling both te...

Mar 10 2026 2603.09392v1
QualiTeacher: Quality-Conditioned Pseudo-Labeling for Real-World Image Restoration

Real-world image restoration (RWIR) is a highly challenging task due to the absence of clean ground-truth images. Many recent methods resort to pseudo...

Mar 9 2026 2603.08030v1
Multimodal Large Language Models as Image Classifiers

Multimodal Large Language Models (MLLM) classification performance depends critically on evaluation protocol and ground truth quality. Studies compari...

Mar 6 2026 2603.06578v1
ICHOR: A Robust Representation Learning Approach for ASL CBF Maps with Self-Supervised Masked Autoencoders

Arterial spin labeling (ASL) perfusion MRI allows direct quantification of regional cerebral blood flow (CBF) without exogenous contrast, enabling non...

Mar 5 2026 2603.05247v1
Large language models for self-administered conversational vignette assessment of provider competencies: A pilot and validation study in Vietnam with automated LLM-powered transcript classification

We developed and validated a self-administered clinical vignette platform powered by a large language model (LLM), deployed through a SurveyCTO web su...

Improved Classification of Acute Physical Fatigue Using Salivary Proteomic Biomarkers: An Exploratory Study

Introduction: Physical fatigue is a key determinant of operational readiness in the physically demanding occupations of tactical athletes. Specific ho...

QCAgent: An agentic framework for quality-controllable pathology report generation from whole slide image

Recent methods for pathology report generation from whole-slide image (WSI) are capable of producing slide-level diagnostic descriptions but fail to g...

Mar 2 2026 2603.01647v1
DLEBench: Evaluating Small-scale Object Editing Ability for Instruction-based Image Editing Model

Significant progress has been made in the field of Instruction-based Image Editing Models (IIEMs). However, while these models demonstrate plausible a...

Feb 27 2026 2602.23622v1
Early Risk Stratification of Dosing Errors in Clinical Trials Using Machine Learning

Objective: The objective of this study is to develop a machine learning (ML)-based framework for early risk stratification of clinical trials (CTs) ac...

Feb 25 2026 2602.22285v1
Development and Validation of CPX-MATE: An End-to-End Medical Education Platform Integrating Voice-Based Virtual Patient Simulation and Automated Real-time Evaluation

Background: Objective Structured Clinical Examination (OSCE; Clinical Performance Examination [CPX] in South Korea) is a high-stakes assessment of cli...

How Agent Role Structure Alters Operating Characteristics of Large Language Model Clinical Classifiers: A Comparative Study of Specialist and Deliberative Multi-Agent Protocols

Large language models (LLMs) are increasingly evaluated for structured clinical decision support tasks, often using multi-agent architectures. Prior w...

Randomized Trial Protocol: Epic Generative AI Chart Summarization Tool to Reduce Ambulatory Provider Cognitive Task Load

Background: EHR documentation and chart review contribute to clinician workload and burnout. To alleviate pre-charting burden, Epic has released a new...

Learning lifetime disease liability reveals and removes genetic confounding in electronic health records

Electronic health records (EHRs) have become the cornerstone of population-scale genetic studies1, but factors including patterns of healthcare use sh...

Agentic Trial Emulation to Learn Health System-specific Drug Effects At Scale

Objective: Electronic Health Record (EHR)-based trial emulation can support translation of randomized clinical trial (RCT) evidence into practice, yet...

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