Sepsis

Anastomotic Leak is Increased With Infection After Colectomy: Machine Learning-Augmented Propensity Score Modified Analysis of 46 735 Patients.

BACKGROUND: infection (CDI) is now the most common cause of healthcare-associated infections, with increasing prevalence, severity, and mortality of nosocomial and community-acquired CDI which makes up approximately one third of all CDI. There are also increased rates of asymptomatic colonization particularly in high-risk patients. is a known collagenase-producing bacteria which may contribute t...

Intraosseous Regional Administration of Antibiotic Prophylaxis in Total Knee Arthroplasty.

BACKGROUND: Periprosthetic joint infection (PJI) is a devastating complication following total knee arthroplasty (TKA), and perioperative antibiotics are commonly administered to try to mitigate the chance of infection. Intraosseous regional administration (IORA) of prophylactic antibiotics during TKA is a method of antibiotic delivery that has been shown to achieve markedly higher tissue concentr...

Repurposing potential of FDA-approved and investigational drugs for COVID-19 targeting SARS-CoV-2 spike and main protease and validation by machine learning algorithm.

The present study aimed to assess the repurposing potential of existing antiviral drug candidates (FDA-approved and investigational) against SARS-CoV-...

Active contour regularized semi-supervised learning for COVID-19 CT infection segmentation with limited annotations.

Infection segmentation on chest CT plays an important role in the quantitative analysis of COVID-19. Developing automatic segmentation tools in a shor...

Detection of transient neurotransmitter response using personalized neural networks.

Measurement of stimulus-induced dopamine release and other types of transient neurotransmitter response (TNR) from dynamic positron emission tomograph...

Necrotic enteritis challenge regulates peroxisome proliferator-1 activated receptors signaling and β-oxidation pathways in broiler chickens.

Necrotic enteritis (NE) is an important enteric disease in poultry and has become a major concern in poultry production in the post-antibiotic era. Th...

Outcomes of surgical and/or medical treatment in patients with prolactinomas during long-term follow-up: a retrospective single-centre study.

OBJECTIVES: Prolactinoma is the most common cause of pituitary tumours. Current medical guidelines recommend dopamine agonists (cabergoline or bromocr...

Computing SARS-CoV-2 Infection Risk From Symptoms, Imaging, and Test Data: Diagnostic Model Development.

BACKGROUND: Assigning meaningful probabilities of SARS-CoV-2 infection risk presents a diagnostic challenge across the continuum of care.

Label-Free Detection of Based on Bacteria-Imprinted Polymer and Turn-on Fluorescence Probes.

The effective identification and quantitative determination of is a major public health concern. Here, an innovative strategy that combines a bacteri...

Nested active learning for efficient model contextualization and parameterization: pathway to generating simulated populations using multi-scale computational models.

There is increasing interest in the use of mechanism-based multi-scale computational models (such as agent-based models (ABMs)) to generate simulated ...

Scaffold-Constrained Molecular Generation.

One of the major applications of generative models for drug discovery targets the lead-optimization phase. During the optimization of a lead series, i...

Hepatitis C viral load and genotypes among Nigerian subjects with chronic infection and implication for patient management: a retrospective review of data.

INTRODUCTION: Hepatitis C Virus (HCV) is highly infectious with no currently available vaccine. Prior to treatment, it is recommended to confirm HCV i...

Moderate to severe leukocytosis with vasopressor use is associated with increased mortality in trauma patients.

BACKGROUND: Leukocytosis is a rise in white blood cell (WBC) count and clinical outcomes of moderate to severe leukocytosis in trauma patients have no...

Selecting Children with Vesicoureteral Reflux Who are Most Likely to Benefit from Antibiotic Prophylaxis: Application of Machine Learning to RIVUR.

PURPOSE: Continuous antibiotic prophylaxis reduces the risk of recurrent urinary tract infection by 50% in children with vesicoureteral reflux. Howeve...

A scaffold hopping strategy to generate new aryl-2-amino pyrimidine MRSA biofilm inhibitors.

Infections that stem from bacterial biofilms are difficult to eradicate. Within a biofilm state, bacteria are upwards of 1000-fold more resistant to c...

Predicting 30-days mortality for MIMIC-III patients with sepsis-3: a machine learning approach using XGboost.

BACKGROUND: Sepsis is a significant cause of mortality in-hospital, especially in ICU patients. Early prediction of sepsis is essential, as prompt and...

Super resolution microscopy and deep learning identify Zika virus reorganization of the endoplasmic reticulum.

The endoplasmic reticulum (ER) is a complex subcellular organelle composed of diverse structures such as tubules, sheets and tubular matrices. Flavivi...

Essential gene prediction using limited gene essentiality information-An integrative semi-supervised machine learning strategy.

Essential gene prediction helps to find minimal genes indispensable for the survival of any organism. Machine learning (ML) algorithms have been usefu...

Intravenous iron therapy and the cardiovascular system: risks and benefits.

Anaemia is a common complication of chronic kidney disease (CKD). In this setting, iron deficiency is frequent because of the combination of increased...

Noninvasive diagnostic of periprosthetic joint infection by urinary peptide markers: A preliminary study.

Previous immunohistochemical analyses revealed altered protein expression in the periprosthetic membranes of patients with periprosthetic joint infect...