Sepsis

Sporulated Bacillus as alternative treatment for diarrhea of hospitalized adult patients under enteral nutrition: A pilot randomized controlled study.

BACKGROUND & AIMS: Among hospitalized patients receiving enteral nutrition (EN), malnutrition and antibiotic use are some of the most common causes of diarrhea. Prebiotics and probiotics agents have been used for treatment of diarrhea in such patients. The aim of this study was to assess the efficacy of a sporulated Bacillus strain (Bacillus cereus A 05), compared to a control group using a prebio...

Compatibility, Stability, and Efficacy of Vancomycin Combined With Gentamicin or Ethanol in Sodium Citrate as a Catheter Lock Solution.

Indwelling catheters deliver lifesaving medical treatments for many chronically ill patients but are frequently a source of infection. Treatment may include an antimicrobial agent(s) and anticoagulant solution dwelling within the catheter. In vitro determinations of solution compatibility and stability are necessary prior to use in patients. The aim of this study was to determine the physical co...

Learning representations for the early detection of sepsis with deep neural networks.

BACKGROUND: Sepsis is one of the leading causes of death in intensive care unit patients. Early detection of sepsis is vital because mortality increas...

Global and local excitation and inhibition shape the dynamics of the cortico-striatal-thalamo-cortical pathway.

The cortico-striatal-thalamo-cortical (CSTC) pathway is a brain circuit that controls movement execution, habit formation and reward. Hyperactivity in...

Physical and chemical stability of ceftaroline in an elastomeric infusion device.

BACKGROUND: Severe infections such as endocarditis and osteomyelitis require long-term treatment with parenteral antibiotics and hence prolonged hospi...

Impairment of Thyroid Function in Critically Ill Patients in the Intensive Care Units.

Unexplained hypotension in the intensive care unit is commonly attributed to volume depletion, cardiorespiratory failure, sepsis, or relative adrenal ...

Hyperspectral Imaging for Presymptomatic Detection of Tobacco Disease with Successive Projections Algorithm and Machine-learning Classifiers.

We investigated the feasibility and potentiality of presymptomatic detection of tobacco disease using hyperspectral imaging, combined with the variabl...

Nanoarmoring: strategies for preparation of multi-catalytic enzyme polymer conjugates and enhancement of high temperature biocatalysis.

We report a general and modular approach for the synthesis of multi enzyme-polymer conjugates (MECs) consisting of five different enzymes of diverse i...

Antifungal properties and biocompatibility of silver nanoparticle coatings on silicone maxillofacial prostheses in vitro.

Patients with facial prostheses suffer from yeast, Candida albicans, infections. This study aimed to determine the biocompatibility and antifungal pro...

Simulating the fate of indigenous antibiotic resistant bacteria in a mild slope wastewater polluted stream.

The fate of indigenous surface-water and wastewater antibiotic resistant bacteria in a mild slope stream simulated through a hydraulic channel was inv...

A sensitive species-specific reverse transcription real-time PCR method for detection of and .

As the global burden of malaria decreases and countries strive towards disease elimination, there is a greater demand for sensitive diagnostics to tar...

Creating an automated trigger for sepsis clinical decision support at emergency department triage using machine learning.

OBJECTIVE: To demonstrate the incremental benefit of using free text data in addition to vital sign and demographic data to identify patients with sus...

Machine-learning algorithms define pathogen-specific local immune fingerprints in peritoneal dialysis patients with bacterial infections.

The immune system has evolved to sense invading pathogens, control infection, and restore tissue integrity. Despite symptomatic variability in patient...

Antidepressant-like effects of Gan-Mai-Dazao-Tang via monoamine regulatory pathways on forced swimming test in rats.

Depression is a highly prevalent and recurrent mental disorder that impacts all aspects of human life. Undesirable effects of the antidepressant drugs...

Prediction of Adverse Events in Patients Undergoing Major Cardiovascular Procedures.

Electronic health records (EHR) provide opportunities to leverage vast arrays of data to help prevent adverse events, improve patient outcomes, and re...

Accelerating Chart Review Using Automated Methods on Electronic Health Record Data for Postoperative Complications.

Manual Chart Review (MCR) is an important but labor-intensive task for clinical research and quality improvement. In this study, aiming to accelerate ...

Learning by stimulation avoidance: A principle to control spiking neural networks dynamics.

Learning based on networks of real neurons, and learning based on biologically inspired models of neural networks, have yet to find general learning r...

Diagnostic value of sTREM-1 and procalcitonin levels in the early diagnosis of sepsis.

OBJECTIVE: Sepsis is still major cause of morbidity and mortality, despite improvements in diagnosis and treatment in modern medicine. Therefore, labo...

Natural language processing to ascertain two key variables from operative reports in ophthalmology.

PURPOSE: Antibiotic prophylaxis is critical to ophthalmology and other surgical specialties. We performed natural language processing (NLP) of 743 838...

Chemical colitis caused by hydrogen peroxide enema in a child: case report and literature review.

A 2-year-old girl, previously healthy, was brought to the emergency department because of significant cramping abdominal pain with recurrent hematoche...