Critical Care

Sepsis

Latest AI and machine learning research in sepsis for healthcare professionals.

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Multidrug Resistant Causing Prosthetic Valve Endocarditis: A Genetic-Based Chronicle of Evolving Antibiotic Resistance.

 Successful treatment of infections caused by multidrug-resistant (MDR) is thwarted by the emergence of antibiotic resistance and biofilm formation on prosthetic devices. Our aims were to decipher the molecular basis of resistance in a unique case of prosthetic valve endocarditis (PVE) caused by MDR .  Five sequential MDR blood isolates collected during a 7-month period were recovered from a p...

Oct 21 2016 29057280

Cytotoxic effects of two extracts from garlic ( L.) cultivars on the human squamous carcinoma cell line SCC-15.

Garlic ( L., Alliaceae) has acquired a reputation as a therapeutic agent and herbal remedy to prevent and treat several pathologies. The aim of the present study was to determine the effect of two L. cultivars, HarnaÅ› and Morado, on reactive oxygen species (ROS) production, viability and apoptotic process in human squamous carcinoma cell line SCC-15. The experiments were conducted on SCC-15 cell ...

Oct 12 2016 30591788
Methanol Extract from Anogeissus leiocarpus (DC) Guill. et Perr. (Combretaceae) Stem Bark Quenches the Quorum Sensing of Pseudomonas aeruginosa PAO1.

Due to its extensive arsenal of virulence factors and inherent resistance to antibiotics, is a threat particularly in immunocompromised patients. Co...

Oct 6 2016 28930136
Experimental phage therapy against haematogenous multi-drug resistant pneumonia in mice.

BACKGROUND: Community-acquired haematogenous pneumonia is a rare infection, though it can be acquired nosocomially. Currently, antibiotics used again...

Sep 30 2016 28879116
Tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of HBeAg-positive chronic hepatitis B virus infection: a randomised, double-blind, phase 3, non-inferiority trial.

BACKGROUND: Tenofovir alafenamide is a novel prodrug formulated to deliver the active metabolite to target cells more efficiently than tenofovir disop...

Sep 22 2016 28404091
Tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of patients with HBeAg-negative chronic hepatitis B virus infection: a randomised, double-blind, phase 3, non-inferiority trial.

BACKGROUND: The novel prodrug tenofovir alafenamide delivers the nucleotide reverse transcriptase inhibitor tenofovir to target cells more efficiently...

Sep 22 2016 28404092
Automated Detection of P. falciparum Using Machine Learning Algorithms with Quantitative Phase Images of Unstained Cells.

Malaria detection through microscopic examination of stained blood smears is a diagnostic challenge that heavily relies on the expertise of trained mi...

Sep 16 2016 27636719
Predicting ventriculoperitoneal shunt infection in children with hydrocephalus using artificial neural network.

OBJECTIVES: The relationships between shunt infection and predictive factors have not been previously investigated using Artificial Neural Network (AN...

Sep 14 2016 27638720
Chemogenomics knowledgebase and systems pharmacology for hallucinogen target identification-Salvinorin A as a case study.

Drug abuse is a serious problem worldwide. Recently, hallucinogens have been reported as a potential preventative and auxiliary therapy for substance ...

Aug 8 2016 27810775
Functional Relevance of Different Basal Ganglia Pathways Investigated in a Spiking Model with Reward Dependent Plasticity.

The brain enables animals to behaviorally adapt in order to survive in a complex and dynamic environment, but how reward-oriented behaviors are achiev...

Jul 21 2016 27493625
Non-reward neural mechanisms in the orbitofrontal cortex.

Single neurons in the primate orbitofrontal cortex respond when an expected reward is not obtained, and behaviour must change. The human lateral orbit...

Jul 15 2016 27474915
Detecting the presence of an indwelling urinary catheter and urinary symptoms in hospitalized patients using natural language processing.

OBJECTIVE: To develop a natural language processing pipeline to extract positively asserted concepts related to the presence of an indwelling urinary ...

Jul 9 2016 27404849
Basal Ganglia dysfunctions in movement disorders: What can be learned from computational simulations.

The basal ganglia are a complex neuronal system that is impaired in several movement disorders, including Parkinson's disease, Huntington's disease, a...

Jul 9 2016 27393040
Machine Learning Model Analysis and Data Visualization with Small Molecules Tested in a Mouse Model of Mycobacterium tuberculosis Infection (2014-2015).

The renewed urgency to develop new treatments for Mycobacterium tuberculosis (Mtb) infection has resulted in large-scale phenotypic screening and thou...

Jul 1 2016 27335215
Ombitasvir, paritaprevir, and ritonavir plus ribavirin in adults with hepatitis C virus genotype 4 infection and cirrhosis (AGATE-I): a multicentre, phase 3, randomised open-label trial.

BACKGROUND: Hepatitis C virus (HCV) genotype 4 infection is most commonly reported in sub-Saharan Africa and the Middle East; however, prevalence is i...

Jun 16 2016 28404108
Joint feature-sample selection and robust diagnosis of Parkinson's disease from MRI data.

Parkinson's disease (PD) is an overwhelming neurodegenerative disorder caused by deterioration of a neurotransmitter, known as dopamine. Lack of this ...

Jun 10 2016 27296013
Application of Machine Learning Techniques to High-Dimensional Clinical Data to Forecast Postoperative Complications.

OBJECTIVE: To compare performance of risk prediction models for forecasting postoperative sepsis and acute kidney injury.

May 27 2016 27232332
Detecting borderline infection in an automated monitoring system for healthcare-associated infection using fuzzy logic.

BACKGROUND: Many electronic infection detection systems employ dichotomous classification methods, classifying patient data as pathological or normal ...

Apr 28 2016 27156053
Adsorptive removal of antibiotics from water using magnetic ion exchange resin.

The occurrence of antibiotics in the environment has recently raised serious concern regarding their potential threat to aquatic ecosystem and human h...

Apr 27 2016 28254029
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