Critical Care

Sepsis

Latest AI and machine learning research in sepsis for healthcare professionals.

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Machine Learning-Based Differential Diagnosis of Parkinson's Disease Using Kinematic Feature Extraction and Selection

Parkinson's disease (PD), the second most common neurodegenerative disorder, is characterized by d...

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Nanopore- and AI-empowered microbial viability inference

The ability to differentiate between viable and dead microorganisms in metagenomic data is crucial f...

Large Language Model-assisted text mining reveals bacterial pathogen diversity

Compiling and characterising the diversity of bacterial pathogens of humans is a critical challenge ...

Neural Timescale of Adolescents Major Depressive Disorder

Adolescent major depressive disorder (MDD) is characterized by heterogeneous symptomatology and comp...

SIMPLICITY: an agent-based, multi-scale mathematical model to study SARS-CoV-2 intra- and between-host evolution

Computational tools are frequently used to describe pathogen evolutionary dynamics either within inf...

Molecular unbalances between striosome and matrix compartments characterize the pathogenesis of Huntington’s disease model mouse

The pathogenesis of Huntington’s disease is still incompletely understood, despite the remarkable ad...

Synaptic sign switching mediates online dopamine updates

In the mammalian brain, excitatory and inhibitory synapses are generally distinct and have fixed syn...

Individual differences in learning and decision-making: the role of COMT Val158Met polymorphism in transitive inference

Understanding the ordinal relationships between items requires constructing a rank order supporting ...

Functional immune state classification of unlabeled live human monocytes using holotomography and machine learning

Precise evaluation of immune status is critical for managing diseases such as sepsis, in which the i...

Mechanistically Informed Machine Learning Links Non-Canonical TCA Cycle Activity to Warburg Metabolism and Hallmarks of Malignancy

Cancer cells undergo extensive metabolic rewiring to support growth, survival, and phenotypic plasti...

A unified derivative-like dopaminergic computation across valences

Dopamine activity in the brain affects decision-making and adaptive behaviors. A wealth of studies i...

Neurometabolic predictors of mental effort in the frontal cortex

Motivation drives individuals to overcome costs to achieve desired outcomes, such as rewards or avoi...

Non-polio enteroviruses compromise the electrophysiology of a human iPSC-derived neural network

The non-polio enteroviruses enterovirus-D68 (EV-D68) and enterovirus-A71 (EV-A71) are highly prevale...

Mesocorticolimbic reinforcement learning of reward representation and value provides an integrated mechanistic account for schizophrenia

Mesocorticolimbic dopamine projections are crucial for value learning, motivational control, and cog...

Subtype-Specific Roles of Nigrostriatal Dopaminergic Neurons in Motor and Associative Learning

Nigrostriatal dopaminergic neurons (DANs) in the substantia nigra pars compacta (SNc) comprise disti...

Acetylcholine demixes heterogeneous dopamine signals for learning and moving

Midbrain dopamine neurons promote both reinforcement learning and movement vigour1–12. A major outst...

Decoding the interconnected splicing patterns of hepatitis B virus and host using large language and deep learning models

Hepatitis B virus (HBV) infection causes approximately one million deaths annually and remains a maj...

Moremi Bio Agent: Leveraging Agentic Large Language Model for the Discovery of Broad-Spectrum Antibiotics for Enterobacteriaceae

Antimicrobial resistance (AMR) is a pressing global health crisis, exacerbated by a stagnating antib...

Large-language-model-based antibiotic resistance gene prediction and resistomes mining in cyanobacterial blooms

The rapid spread of antibiotic resistance genes (ARGs) in aquatic ecosystems poses a serious public ...

Effects of the Neutral CB1 Receptor Antagonist AM6527 on Spontaneous, Consummatory, and Motivated Behavior in Mice

The cannabinoid type-1 receptor (CB1R) signaling pathway plays a central role in regulating motivati...

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