Sepsis

Corticosteroid Stewardship: Can it help us avoid the corticosteroid trap? Journal of Allergy and Clinical Immunology: In Practice.

With an almost 20-year experience with asthma biologics, it is now clear that a major impact of all available asthma biologics is the opportunity to reduce the frequency of asthma exacerbations, along with the concomitant use of systemic corticosteroids. The asthma biologics allow for the reduction and occasionally discontinuation of maintenance systemic corticosteroids and permit reduction of hig...

Autonomous Vascular Access Devices: Current Solutions and Future Challenges.

INTRODUCTION: Central venous cannulation is essential for life-saving interventions including resuscitation of critically ill patients, hemodynamic monitoring, endovascular intervention, pressor therapy, dialysis and apheresis, and extracorporeal life support. Cannulation of major arteries is required for cardiac catheterization, endovascular interventions such as arterial stenting or aneurysm rep...

Dehiscence, Infection, Seroma, Haematoma (DISH): Development and Validation of a New Classification of Surgical Site Outcomes.

BACKGROUND: Surgical site outcome (SSO) reporting lacks details of management, focuses on infection, and overlooks dehiscence, seroma and haematoma. A...

Integrated Clinical-Molecular Risk Stratification in Diffuse Large B-Cell Lymphoma: Machine Learning Survival Analysis.

BACKGROUND: The clinical outcomes of diffuse large B-cell lymphoma (DLBCL) are highly heterogeneous. While clinical indices like the international pro...

Robot-assisted rehabilitation therapy for adhesive capsulitis: A pilot randomized controlled trial on clinical and patient-reported outcomes.

BACKGROUND: Adhesive capsulitis, commonly known as frozen shoulder, presents with pain and restricted movement. Treatments include physical therapy fo...

Artificial intelligence-assisted phenotyping of sepsis: Research progress, clinical challenges, and translational prospects.

Sepsis remains a leading cause of mortality in intensive care units worldwide, a challenge exacerbated by pathophysiological and clinical heterogeneit...

Spiramycin (SPR) antibiotics degradation with WO3 photocatalyst and ML XGBoost model for process parameters screening.

The intensification of worldwide urbanization and industrial growth has led to a rise in the release of toxic substances into the environment. Antibio...

Therapeutic targeting of G protein-coupled receptors in central nervous system disorders: from novel mechanisms to precision pharmacology.

G protein-coupled receptors (GPCRs) are major therapeutic targets for central nervous system disorders, with more than 500 approved drugs targeting th...

Development and validation of a machine learning-based model for identifying liver fibrosis in individuals with prior Schistosoma japonicum infection: a step toward precision management.

BACKGROUND: Liver fibrosis caused by Schistosoma japonicum may continue to progress even following successful praziquantel chemotherapy. Although live...

Correction to "Improving Sepsis Mortality Prediction With Machine Learning Using Full Region Synthetic Sampling Approach".

[This corrects the article DOI: 10.1002/hsr2.71556.].

Integrated evaluation of rapid diagnostic testing, genotypic-phenotypic resistance profiling, and AI-Assisted prediction models for antimicrobial stewardship and clinical outcomes in a resource-limited setting.

INTRODUCTION: Antimicrobial resistance (AMR) remains a major global health concern, necessitating timely and accurate diagnostic approaches to guide a...

Gut microbiome signatures during acute infection are associated with long COVID.

BACKGROUND: Long COVID (LC) manifests in 10%-30% of non-hospitalized individuals post-SARS-CoV-2 infection, leading to significant morbidity. The pred...

Targeting FAR1 to inhibit intestinal macrophage ferroptosis: repurposing irinotecan as a novel sepsis therapy.

Intestinal barrier breakdown is a key driver of sepsis-related multiple organ dysfunction; however, the metabolic mechanisms underlying this process r...

Early Sepsis Prediction Using Interpretable Models.

Sepsis remains a major cause of morbidity and mortality in Intensive Care Units (ICUs). Timely identification of sepsis can prevent severe complicatio...

Hydrogen sulfide ameliorates cognitive dysfunction in diabetic encephalopathy by activating PI3K/AKT/GSK-3β signaling to attenuate tau hyperphosphorylation and necroptosis.

Diabetic encephalopathy (DE) is a serious complication of diabetes mellitus characterized by progressive cognitive dysfunction; but its underlying mec...

AI-assisted endoscopic detection of Helicobacter pylori infection in atrophic gastritis: a multicenter diagnostic study.

BACKGROUND: Convolutional neural network (CNN)-based artificial intelligence systems have demonstrated promise in detecting Helicobacter pylori (Hp) i...

Microbiome-Driven Precision Medicine in Asthma: Roles of Targeted Therapies and Artificial Intelligence.

OBJECTIVE: To evaluate the current evidence regarding airway and gut microbiome alterations in asthma pathogenesis and therapeutic response, and to ex...

Deep Learning-Assisted RTP Sensor Array Based on a Melt-Injection Reaction for Visual Discrimination of Fluoroquinolone Antibiotics.

The widespread residue and structural similarity of fluoroquinolone antibiotics (FQs) pose a critical requirement for analytical methods capable of bo...

An Ultrasensitive Multiplexing Approach via Integrating Boosted Nanozyme Activity with Multidimensional Information for Antibiotic Recognition.

Most studies focus on improving the activity of nanozymes to build a nanozyme-based "chemical tongue" for the sensitive discrimination of multiple ana...

Recent advances in the defense mechanisms of arbuscular mycorrhizal fungi in antibiotic-contaminated soil ecosystems.

Arbuscular mycorrhizal fungi (AMF) are important soil symbionts that support plant nutrient acquisition, stress tolerance, and soil ecosystem stabilit...