Critical Care

Sepsis

Latest AI and machine learning research in sepsis for healthcare professionals.

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Critical-Care Subcategories: Sepsis
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The Evaluation of Machine Learning Models Using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF-MS) Spectra for the Prediction of Antibiotic Resistance in Klebsiella pneumoniae.

Antimicrobial resistance in Klebsiella pneumoniae poses a major clinical challenge, driving development in rapid, diagnostic strategies that extend beyond conventional susceptibility testing. Twenty-three studies demonstrate that using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) spectra to create machine learning (ML) models yields rapid and accurate...

Apr 1 2026 41771780

Models Integrating Disease Heterogeneity and MPA Exposure Predict Systemic and Renal Efficacy of Mycophenolate in Pediatric Lupus Nephritis.

OBJECTIVES: This study aimed to develop and validate integrated prediction models for pediatric lupus nephritis (LN) treated with a mycophenolate mofetil (MMF)-based induction regimen (combined with glucocorticoids and hydroxychloroquine), incorporating both disease heterogeneity and pharmacokinetic variability. The primary model predicts the achievement of low disease activity (Systemic Lupus Ery...

Apr 1 2026 41801808
Development and Internal Validation of a Gradient Boosting Model for Pressure Injury Risk in the ICU.

Pressure injury (PI) is common in the ICU and not well captured by single-risk tools such as the Braden scale. We aimed to develop and internally vali...

Apr 1 2026 41895787
Short-chain fatty acid-producing microbes differentiate non-infectious and infectious neutropenic fever in leukemia.

UNLABELLED: Neutropenic fever (NF) is often the first sign of infection in patients with hematologic malignancies, but its cause is frequently unknown...

Mar 31 2026 41914747
Perspective: Depression in Persons with Parkinson's Disease.

Depression is a prevalent and disabling syndrome characterized by sustained sadness and/or anhedonia, as well as cognitive and physical symptoms. In P...

Mar 31 2026 41916878
A Systematic Review and Meta-analysis of Externally Validated Epic Clinical Decision Support Tools.

BACKGROUND: Clinical Decision Support (CDS) tools integrated with Electronic Health Records increasingly guide clinical practice. Epic Systems, storin...

Mar 31 2026 41917292
Conventional and novel platelet parameters: Clinical and laboratory approaches.

INTRODUCTION: Platelet count and related indices obtained from the complete blood count (CBC) play an important role in the diagnosis, monitoring, and...

Mar 30 2026 41921724
Revisiting the NETs-CYBB-p38 MAPK axis in bronchiectasis: The underlying oxidative injury mechanism.

BACKGROUND: Bronchiectasis is a chronic neutrophilic respiratory disease frequently complicated by Pseudomonas aeruginosa (P. aeruginosa) infection. N...

Mar 30 2026 41916025
Automated hemodynamic management system for the prevention of hypotension and cardiac output reduction during general anesthesia: preclinical experimental validation.

PURPOSE: Intraoperative hypotension and cardiac output (CO) reduction adversely affect outcomes and require cause-specific treatment against vasodilat...

Mar 30 2026 41910643
AI-guided multi-omics analysis identifies NPC1-modulated susceptibility to SARS-CoV-2 infection under PM2.5 exposure.

Exposure to airborne fine particulate matter (PM2.5) has been linked to increased risk of the severe acute respiratory syndrome coronavirus 2 (SARS-Co...

Mar 30 2026 41912520
WGCNA and machine learning identify mitochondria programmed cell death-related genes as diagnostic biomarkers for septic shock.

Septic shock (SS), the most severe stage of sepsis, has a high mortality rate. Mitochondria-mediated programmed cell death (MPCD) plays a key role in ...

Mar 28 2026 41902830
Clinical Care Practices Shape Microbiome-Associated Bloodstream Infection Risk in Geographically Distinct NICUs.

BACKGROUND: Bloodstream infections (BSI) remain a major cause of morbidity and mortality in preterm infants. Although BSI pathogens vary geographicall...

Mar 28 2026 41903180
Artificial intelligence and multi-omic empowered-tracing macrophage diagnostic and druggable implications in coronavirus pneumonia.

BACKGROUND: As the innate immune barrier, macrophages play an important role in coronavirus infection pneumonia and post-infection regeneration. OBJEC...

Mar 27 2026 41916102
Adaptive acoustic streaming microbial system for oxytetracycline removal.

Microalgae-bacteria symbiosis has been demonstrated to possess the ability to remove antibiotics from water. Appropriate granulation strategies enhanc...

Mar 27 2026 41905672
Proteomic profiling and pathway analyses reveal molecular signatures and immune networks in pediatric sepsis.

BACKGROUND: Sepsis remains a leading cause of childhood mortality worldwide. Most deaths occur within the first few days of presentation, underscoring...

Mar 27 2026 41896381
PTBD: a machine learning-based non-invasive diagnostic model for pulmonary tuberculosis using large-scale blood transcriptomes.

BACKGROUND: Accurate and rapid diagnosis is essential for controlling pulmonary tuberculosis (PTB) by enabling timely intervention and reducing diseas...

Mar 27 2026 41888771
An improved dataset for predicting mammal infecting viruses from genetic sequence information.

There have been several attempts to develop machine learning (ML) models to identify human infecting viruses from their genomic sequences, with varyin...

Mar 27 2026 41894437
At the Edge of Chaos: Complexity Science and Critical Care in the Era of Artificial Intelligence.

Critical care unfolds at the crossroads of highly complex, nonlinear systems. The intersection of pathophysiology, human behavior, and clinical operat...

Mar 26 2026 41894662
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