Skin Cancer

Novel biomarkers driving treatment selection in metastatic castration-sensitive prostate cancer: fundamentals of personalized clinical decision making.

INTRODUCTION: Prostate cancer is well known to be androgen-dependent, with growth directly relying on the androgen receptor signaling pathway. In fact, androgen deprivation therapy, with or without Docetaxel and/or newer hormonal drugs such as Abiraterone acetate, Enzalutamide, Apalutamide, and Darolutamide, remains the most effective systemic treatment for metastatic disease. Beyond PSA detection...

Nanomedicine carrier-based combined antitumor strategy integrating phototherapy and immunotherapy.

INTRODUCTION: The combination of phototherapy (PTT/PDT) and immunotherapy holds promise for cancer treatment but is hindered by poor spatiotemporal coordination and inadequate targeted co-delivery. Nanomedicine carriers offer a platform to overcome these barriers by enabling precise control over drug release kinetics and reducing off-target toxicity. Methods This review systematically analyzes the...

Genome-wide variation in cell-free DNA end motif entropy predicts immunotherapy response in head and neck cancer.

BACKGROUND: Minimally invasive biomarkers predicting immunotherapy response in head and neck squamous cell carcinoma (HNSCC) remain an unmet clinical ...

Development and validation of artificial intelligence-based model for bladder cancer immunophenotyping using whole slide images.

The classification of immunophenotypes in muscle-invasive bladder cancer (MIBC) is critical for predicting immunotherapy response and clinical outcome...

Synthetic Inducible Bacteria Normalize the Microenvironment of Refractory Tumors, Potentiating Checkpoint Inhibitor Responses.

Immunotherapy has transformed cancer treatment but remains ineffective in many solid tumors, largely due to the immunosuppressive tumor microenvironme...

Clinical outcomes and predictors of response to PD-(L)1 blockade in patients with NSCLC without actionable genomic alterations who never used tobacco.

PURPOSE: Predictive biomarkers of response to immune checkpoint inhibitors (ICI) remain poorly defined in patients with non-small cell lung cancer (NS...

Calcite nanoparticles as advanced, pH-responsive platforms for cancer therapy: a comprehensive and critical review.

Nanomedicine offers powerful opportunities to overcome the pharmacokinetic and microenvironmental limitations of conventional chemotherapy, particular...

A longitudinal whole-body CT dataset with manually annotated tumor lesions.

We introduce Longitudinal-CT, a publicly available resource of whole-body computed tomography (CT) studies with exhaustive expert manual annotations o...

A robust stacked ensemble strategy with multi-optimizer CNN models for skin cancer classification.

Skin cancer is one of the most prevalent and potentially life-threatening cancers globally, making it a critical area of focus in medical research. Ea...

Cytokines and immunologic checkpoint molecules in predicting success of allergen immunotherapy.

There are large variations in how individual patients respond to allergen immunotherapy (AIT) against grass and/or birch allergy. There are currently ...

Machine learning-based integrative analysis identifies CXCL13-driven tertiary lymphoid structures as favorable immune and prognostic features in osteosarcoma.

BACKGROUND: Osteosarcoma, an aggressive bone malignancy with limited response to immunotherapy, remains a major clinical challenge. Tertiary lymphoid ...

cGAS-STING pathway regulated by spatiotemporal heterogeneity of tumor microenvironment and precision therapy strategies in lung cancer.

The cGAS-STING pathway is a central regulator of innate immunity and exhibits a complex dual function in lung cancer: it can activate anti-tumor immun...

Prognostic Significance and Therapeutic Implications of Migrasome-related genes in Sorafenib Treatment for Primary Liver Cancer.

PURPOSE: This study aimed to reveal the mechanism and prognostic significance of migrasome-related genes (MGs) in primary liver cancer (PLC) treated w...

Advancing equity in endometrial cancer: A narrative synthesis using a cluster-informed framework for resource-stratified implementation.

Endometrial cancer incidence and mortality are rising globally, disproportionately affecting health systems facing diagnostic, therapeutic, and surviv...

Integrating spatial and single-cell transcriptomics via machine learning to characterize efferocytosis in hepatocellular carcinoma prognosis and immunotherapy.

BACKGROUND: The intratumoral heterogeneity and immunosuppressive microenvironment of hepatocellular carcinoma (HCC) significantly limit therapeutic ef...

Artificial intelligence with deep learning driven entropy-curvature attention mechanism for detection and segmentation of skin lesions using biomedical images.

In medical image analysis, skin lesion diagnosis remains a complicated task. Skin lesions are a prevalent form of skin disease that exists globally. A...

Crotonylation: A Novel Layer of the Epigenetic Landscape in Disease.

Crotonylation is a lysine acylation modification that links cellular metabolism to epigenetic regulation. Its rigid planar crotonyl group is specifica...

Micropeptides in Cancer and Immunity: Diagnostic, Therapeutic, and Synthetic Biology Frontiers.

Micropeptides are emerging as a previously hidden layer of the human proteome, redefining the long-standing separation between coding and noncoding ge...

Political determinants of melanoma: Global inequities in skin cancer care.

BACKGROUND: Melanoma outcomes differ across countries, income settings, and skin tones, reflecting not only variable environmental and genetic risks b...

Droplet microfluidic profiling of NK cell cytotoxicity with machine learning-enabled target-cell death analysis.

Predicting the clinical efficacy of Natural Killer (NK) cell immunotherapies remains challenging due to functional heterogeneity within effector popul...