Skin Cancer

Early ctDNA stratifies survival in locally advanced and oligometastatic lung cancer treated with radiotherapy.

PURPOSE: Circulating tumor fraction estimate (ctFE) is a machine learning-derived composite metric o...

Integration of Single-Cell RNA Sequencing and Machine Learning to Identify and Validate Prognostic Genes With Lymph Node Metastasis and Immune Cell Signatures in Lung Adenocarcinoma.

The poor prognosis of lung adenocarcinoma (LUAD) remains unimproved. This study aimed to identify ly...

Multi-Omics and Machine Learning-Uncovered FLT1-Mediated Epithelial-Endothelial Crosstalk in Cellular Senescence Driving Clear Cell Renal Cell Carcinoma Malignancy.

Clear cell renal cell carcinoma (ccRCC) is distinguished by the absence of definitive diagnostic mar...

Radiomics for predicting microsatellite instability-high status in colorectal cancer: a systematic review and meta-analysis.

OBJECTIVE: Microsatellite instability (MSI) has emerged as a key predictive biomarker for chemothera...

Integrating single-cell transcriptomics and machine learning to predict breast cancer prognosis and immunotherapy sensitivity: a study based on proliferating T cells.

Multi-Omics and Machine Learning Analyses Reveal PIK3CG, PRKCD, and TRIM22 as Potential Markers of Poor Prognosis and Immune Activation in Glioblastoma.

BACKGROUND: Glioblastoma (GBM) is one of the most aggressive brain tumors with a poor prognosis desp...

A machine learning-driven framework integrating cell death and senescence signatures for multi-target drug design and immunotherapy optimization in ovarian cancer.

Ovarian cancer (OC) remains therapeutic challenge due to its complex molecular heterogeneity and the...

Reinventing miRNA cancer therapy through immunomodulation and AI.

Despite the rational therapeutic premise of microRNA (miRNA) replacement or inhibition for cancer tr...

A macrophage co-expression signature enables robust prognostic prediction in glioblastoma.

BACKGROUND: Glioblastoma (GBM) exhibits profound cellular heterogeneity and a highly immunosuppressi...

3D-printed real-time biosensing system integrating deep learning for label-free in vitro T cell culture analysis.

Recent advances in T cell-based immunotherapies highlight the urgent need for precise and dynamic mo...

Gene-level gut microbiome signatures as predictive biomarkers for response to immune checkpoint inhibitors across multiple cancer types.

Targeting programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CT...

Deep Learning and Experimental Validation of BRCA1-Associated Protein-1 Missense Variant Pathogenicity in Uveal Melanoma.

OBJECTIVE: To benchmark the pathogenicity predictions of AlphaMissense, a deep learning model, again...

Nanomaterials reshaping cancer radiotherapy: Radiosensitization mechanisms, delivery and theranostic platforms, multimodal synergy, and clinical translation strategies.

Radiotherapy (RT) remains a cornerstone of cancer management but is fundamentally constrained by nor...

Crosstalk between immune and programmed cell death and their application in colorectal cancer risk stratification.

Programmed cell death (PCD) and cellular immunity play pivotal roles in colorectal cancer (CRC) prog...

Optimal treatment selection for hepatocellular carcinoma in the era of immunotherapy.

Immunotherapy has revolutionized hepatocellular carcinoma (HCC) management, necessitating personaliz...

Clinician-deployable deep hypergraph model integrating clinical and CT radiomics predicts immunotherapy outcomes in NSCLC.

Current image-based deep learning models that predict the benefits of immunotherapy in non-small cel...

A Roadmap to Transform Lung Cancer Outcomes: Priorities in Biology, Therapeutic Innovation, Early Detection, Prevention and Interception.

Advances in targeted therapies, immunotherapy, and early detection have revolutionized lung cancer t...

[Current status and future perspectives of precision treatment for locally advanced rectal cancer].

The treatment paradigm for locally advanced rectal cancer is undergoing a fundamental transformation...

[Research progress in clinical pathology and molecular mechanisms of pancreatic adenosquamous carcinoma].

Pancreatic adenosquamous carcinoma (PASC) is a rare exocrine malignancy of the pancreas with an incr...

Beyond chemotherapy: The rise of nucleic acid nanoformulations in personalized lung cancer therapy.

Lung cancer remains the leading cause of cancer-related mortality worldwide, driven by complex cross...

Macrophage polarization as a therapeutic target in lung diseases: From pathogenesis to precision intervention.

Macrophages serve as core effector cells of the innate immune system, exerting dual regulatory roles...