Skin Cancer

Fairness aware subset selection for advancing equity in skin cancer detection.

OBJECTIVES: Skin cancer is the most common malignancy in the United States, with more than five million cases diagnosed annually among 3.3 million individuals. Melanoma, the deadliest form of skin cancer, accounts for roughly 200 000 new diagnoses each year and nearly 10 000 deaths. AI-based skin cancer detection is being developed and tested in laboratory and academic settings as a promising appr...

Increased Prevalence of Extrathymic Neoplasms in Myasthenia Gravis Patients-A Population-Based, Matched Case-Control Study.

INTRODUCTION/AIMS: Myasthenia gravis (MG) is associated with thymic neoplasms. However, an increased prevalence of extrathymic neoplasms has also been reported. This study aimed to evaluate the rates of malignancy in MG patients while accounting for risk factors such as disease characteristics and immunomodulatory treatments. METHODS: We conducted a case-control study using the Clalit Health Servi...

Enhancing adverse drug event extraction and summarization for cancer drugs through large language models.

PURPOSE: Cancer treatments such as chemotherapy, targeted therapy, and immunotherapy can effectively combat malignant cells but frequently cause serio...

The dual role of the crosstalk between autophagy and ferroptosis in lung cancer treatment: Advances in mechanisms and therapeutic strategies (Review).

The interaction between autophagy and ferroptosis has resulted in the identification of novel approaches for the treatment of lung cancer (LC). The tw...

Artificial intelligence in immunotherapy: revolutionizing diagnostic and therapeutic applications in cancer and autoimmune diseases.

Development of a Classifier for Metabolic Subtypes of Nasopharyngeal Carcinoma to Guide Personalized Immunotherapy Strategies: Biomarker Analysis of the Phase III CONTINUUM and DIPPER Trials.

PURPOSE: Personalized immunotherapy strategies are urgently needed for patients with locoregionally advanced nasopharyngeal carcinoma (NPC). We aim to...

Context-Aware adaptive normalization LSTM (CAAN-LSTM) for immunotherapy decision support in cancer clinical data analysis.

BACKGROUND: Clinical decision-making for cancer immunotherapy is challenged by the heterogeneous and often incomplete nature of patient time-series da...

Reflectance confocal microscopy in the management of lentigo maligna and lentigo maligna melanoma: a systematic review.

BACKGROUND: Lentigo maligna (LM) and lentigo maligna melanoma (LMM) are difficult to manage because of their subclinical extension and ill-defined mar...

Harnessing lipid-driven immunometabolic pathways in omental metastases to enhance immunotherapy in patients with ovarian cancer.

Immunotherapy with immune checkpoint blockade (ICB) in epithelial ovarian carcinoma (EOC) shows limited clinical benefit only for a small subset of pa...

Neoadjuvant Systemic Therapy in Kidney and Bladder Cancer: Current Evidence and Emerging Paradigms.

Neoadjuvant systemic therapy has emerged as a strategy to improve outcomes in high-risk localized genitourinary malignancies. In bladder cancer, neoad...

Integrating machine learning of bulk and single cell RNA data to characterize immune mechanism of m6A related mitophagy genes in malignant gastric cancer.

BACKGROUND AND OBJECTIVE: Gastric cancer is a heterogeneous and complicated epithelial cancers. Chronic H. pylori and EBV infection, as well as intest...

Influence of body composition on the efficacy of nivolumab plus ipilimumab for metastatic clear cell renal cell carcinoma.

BACKGROUND: Immune checkpoint inhibitor therapy (ICI) with nivolumab+ipilimumab is a first-line (1L) standard for metastatic clear cell renal cell car...

TCR sequencing in cancer immunology and immunotherapy: what, when, where, why, and how.

T-cell receptors (TCRs) are generated through somatic recombination of variable (V), diversity (D), and joining (J) gene segments, resulting in an ext...

A high density of T-cell lymphocytes and Tregs subset correlate to a worse survival in major salivary gland carcinomas.

Salivary gland carcinomas (SGC) are rare and heterogeneous tumors with limited therapeutic options in advanced stages. Recent evidence suggests a pote...

GSDME-mediated pyroptosis modulates the immunosuppressive microenvironment in lung adenocarcinoma.

Despite the increasing recognition of pyroptosis, particularly that involving GSDME, its precise impact on tumor prognosis and the immune microenviron...

Multi-omics profiling reveals cholic acid-mediated immunosuppression driven by peritumoral ductular reactions in hepatocellular carcinoma.

Hepatocellular carcinoma remains a leading cause of cancer mortality worldwide, with peritumoral microenvironment interactions playing a critical role...

Distinct Tumor-Immune Ecologies in Patients with Lung Cancer Predict Progression and Define a Clinical Biomarker of Therapy Response.

UNLABELLED: Multiplexed imaging of tissues is an approach that holds promise for improving early detection, diagnosis, and treatment of cancer. In thi...

Developing a Metabolic-Associated Prognostic Index for Risk Stratification and Therapeutic Guidance in Stage I Lung Adenocarcinoma via Multiomics Analysis.

PURPOSE: Early-stage lung adenocarcinoma (LUAD) exhibits substantial clinical heterogeneity that is not fully explained by TNM staging, highlighting t...

Machine Learning Reveals the Association Between Gene Expression and Immune Infiltration in Colorectal Cancer: A Comprehensive Study From Single-Cell to Survival Analysis.

Colorectal cancer (CRC) is one of the most common causes of cancer mortality globally. Analysis of immune cell infiltration patterns in the tumour mic...

Adverse reactions of PD-1/PD-L1 inhibitors in cancer: FAERS database analysis and protocols to mitigate immune-related events in elderly patients and when using pembrolizumab and atezolizumab.

OBJECTIVE: This study aimed to characterize adverse drug reactions (ADRs) associated with programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) in...