Latest AI and machine learning research in skin cancer for healthcare professionals.
BACKGROUND: Sjögren's disease (SjD), mucosa-associated lymphoid tissue lymphoma (MALT lymphoma), and thyroid cancer (THCA) are clinically distinct yet immunologically intertwined diseases characterized by chronic inflammation and aberrant immune activation. However, the shared molecular basis linking autoimmunity and oncogenesis remains poorly defined. METHODS: We performed an integrative transcri...
The tumor immune microenvironment (TME) is pivotal in regulating cancer initiation, progression, and therapeutic response. Despite major advances in immunotherapy, clinical outcomes remain limited by low response rates and unpredictable immune-related adverse events (irAEs). Surface-enhanced Raman scattering (SERS) technology, with its single-molecule sensitivity and multiplexing capabilities, off...
BACKGROUND: Hepatocellular carcinoma (HCC) is a common and aggressive form of cancer. There is an interplay between ferroptosis and lipid metabolism i...
BACKGROUND: Cutaneous melanoma is one of the most aggressive forms of skin cancer, marked by rapid progression, early metastasis, and high resistance ...
BACKGROUND: Renal cell carcinoma (RCC) is a common, often lethal kidney cancer that originates in the renal cortex. Its incidence is rising, and major...
RATIONALE AND OBJECTIVES: PD-L1 expression is a critical biomarker in guiding immunotherapy for gastric cancer (GC). This study aims to investigate th...
B-cell-directed immunotherapy holds great promise for treating solid tumors, where barriers such as desmoplastic stroma and low immunogenicity have li...
Non-small cell lung cancer (NSCLC) presents persistent challenges in immunotherapy, as the clinical benefit of programmed cell death protein 1 (PD-1) ...
Hepatocellular carcinoma (HCC), the most common form of primary liver cancer, remains a major global health concern due to its high incidence and mort...
The immunosuppressive tumor microenvironment (TME) enables cancer cells to evade clinical immunotherapies. Neural networks are vital components of the...
BACKGROUND: Cancer-associated fibroblasts (CAFs) are key players in the tumor microenvironment (TME), but their roles in prognosis and immunotherapy r...
The gut microbiome is recognized as a determinant of response to immune checkpoint inhibitor (ICI) therapies in cancer. However, the clinical translat...
Direct reprogramming of immune cells holds promise for immunotherapy but is constrained by limited knowledge of transcription factor (TF) networks. He...
The rapid development of multimodal large language models (LLMs) such as GPT and Med-PaLM is reshaping medical practice. Skin cancer, one of the most ...
Chimeric antigen receptor T-cell (CAR-T) therapy has achieved unprecedented success in hematological malignancies but faces formidable challenges in s...
PURPOSE: This study aims to develop an artificial intelligence (AI) model to assist ophthalmologists in distinguishing ocular surface squamous neoplas...
RNA therapeutics have come of age as clinically validated modalities including mRNA, siRNA, antisense oligonucleotides (ASOs), and in vivo genome edit...
Melanoma, an aggressive form of skin cancer, demands innovative immunotherapeutic strategies to improve patient outcomes. This review explores recent ...
Cancer cells face a hostile microenvironment characterized by hypoxia, nutrient deprivation, endoplasmic reticulum (ER) stress, and oxidative imbalanc...
Neoadjuvant immunochemotherapy (NAIC) is a standard treatment for triple-negative breast cancer (TNBC), but there is no reliable biomarker to identify...