Oncology/Hematology

Skin Cancer

Latest AI and machine learning research in skin cancer for healthcare professionals.

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Integration of graph neural networks and transcriptomics analysis identify key pathways and gene signature for immunotherapy response and prognosis of skin melanoma.

OBJECTIVE: The assessment of immunotherapy plays a pivotal role in the clinical management of skin melanoma. Graph neural networks (GNNs), alongside other deep learning algorithms and bioinformatics approaches, have demonstrated substantial promise in advancing cancer diagnosis and treatment strategies.

Apr 9 2025 40205338

Integrated bioinformatics analysis to develop diagnostic models for malignant transformation of chronic proliferative diseases.

The combined analysis of dual diseases can provide new insights into pathogenic mechanisms, identify novel biomarkers, and develop targeted therapeutic strategies. Polycythemia vera (PV) is a chronic myeloproliferative neoplasm associated with a risk of acute myeloid leukemia (AML) transformation. However, the chronic nature of disease transformation complicates longitudinal high-throughput sequen...

Apr 7 2025 40201199
Combining multi-omics analysis with machine learning to uncover novel molecular subtypes, prognostic markers, and insights into immunotherapy for melanoma.

BACKGROUND: Melanoma (SKCM) is an extremely aggressive form of cancer, characterized by high mortality rates, frequent metastasis, and limited treatme...

Apr 7 2025 40200221
Large-scale bulk and single-cell RNA sequencing combined with machine learning reveals glioblastoma-associated neutrophil heterogeneity and establishes a VEGFA neutrophil prognostic model.

BACKGROUND: Neutrophils play a key role in the tumor microenvironment (TME); however, their functions in glioblastoma (GBM) are overlooked and insuffi...

Apr 5 2025 40188324
MIST: An interpretable and flexible deep learning framework for single-T cell transcriptome and receptor analysis.

Joint analysis of transcriptomic and T cell receptor (TCR) features at single-cell resolution provides a powerful approach for in-depth T cell immune ...

Apr 4 2025 40184452
101 Machine Learning Algorithms for Mining Esophageal Squamous Cell Carcinoma Neoantigen Prognostic Models in Single-Cell Data.

Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive malignant tumors in the digestive tract, characterized by a high recurrence ra...

Apr 4 2025 40244296
Using Real-World Data for Machine-Learning Algorithms to Predict the Treatment Response in Advanced Melanoma: A Pilot Study for Personalizing Cancer Care.

PURPOSE: The use of real-world data (RWD) in oncology is becoming increasingly important for clinical decision making and tailoring treatment. Despite...

Apr 4 2025 40184559
Prediction of PD-L1 expression in NSCLC patients using PET/CT radiomics and prognostic modelling for immunotherapy in PD-L1-positive NSCLC patients.

AIM: To develop a positron emission tomography/computed tomography (PET/CT)-based radiomics model for predicting programmed cell death ligand 1 (PD-L1...

Apr 2 2025 40375402
Artificial intelligence predicts multiclass molecular signatures and subtypes directly from breast cancer histology: a multicenter retrospective study.

Detection of biomarkers of breast cancer incurs additional costs and tissue burden. We propose a deep learning-based algorithm (BBMIL) to predict clas...

Apr 1 2025 39764584
A weakly supervised deep learning framework for automated PD-L1 expression analysis in lung cancer.

The growing application of immune checkpoint inhibitors (ICIs) in cancer immunotherapy has underscored the critical need for reliable methods to ident...

Mar 31 2025 40230846
Multiomics evaluation and machine learning optimize molecular classification, prediction of prognosis and immunotherapy response for ovarian cancer.

BACKGROUND: Ovarian cancer (OC), owing to its substantial heterogeneity and high invasiveness, has historically been devoid of precise, individualized...

Mar 29 2025 40168774
Deciphering aging-associated prognosis and heterogeneity in gastric cancer through a machine learning-driven approach.

Gastric cancer (GC) is a prevalent malignancy with a high mortality rate and limited treatment options. Aging significantly contributes to tumor progr...

Mar 28 2025 40256325
Machine learning based intratumor heterogeneity related signature for prognosis and drug sensitivity in breast cancer.

Intratumor heterogeneity (ITH) is involved in tumor evolution and drug resistance. Drug sensitivity shows discrepancy in different breast cancer (BRCA...

Mar 28 2025 40155597
Bibliometric and LDA analysis of acute rejection in liver transplantation: Emerging trends, immunotherapy challenges, and the role of artificial intelligence.

With the rising demand for liver transplantation (LT), research on acute rejection (AR) has become increasingly diverse, yet no consensus has been rea...

Mar 28 2025 40152403
Unveiling the power of Treg.Sig: a novel machine-learning derived signature for predicting ICI response in melanoma.

BACKGROUND: Although immune checkpoint inhibitor (ICI) represents a significant breakthrough in cancer immunotherapy, only a few patients benefit from...

Mar 28 2025 40226609
Automated assessment of skin histological tissue structures by artificial intelligence in cutaneous melanoma.

BACKGROUND: Prognostic histopathological features such as mitosis in melanoma are excluded from the staging systems due to inter-observer variability ...

Mar 27 2025 40158269
SIMVI disentangles intrinsic and spatial-induced cellular states in spatial omics data.

Spatial omics technologies enable analysis of gene expression and interaction dynamics in relation to tissue structure and function. However, existing...

Mar 27 2025 40148341
The Role of Eosinophils, Eosinophil-Related Cytokines and AI in Predicting Immunotherapy Efficacy in NSCLC Cancer.

Immunotherapy and chemoimmunotherapy are standard treatments for non-oncogene-addicted advanced non-small cell lung cancer (NSCLC). Currently, a limit...

Mar 27 2025 40305195
Development of an external quality assurance (EQA) structure to evaluate the quality of genetic pathology reporting.

A standard for reporting genetic pathology results currently does not exist as a consensus. While effective reports are produced, there is lack of con...

Mar 25 2025 40147806
Exploring the Views of Dermatologists, General Practitioners, and Melanographers on the Use of AI Tools in the Context of Good Decision-Making When Detecting Melanoma: Qualitative Interview Study.

BACKGROUND: Evidence that artificial intelligence (AI) may improve melanoma detection has led to calls for increased human-AI collaboration in clinica...

Mar 24 2025 40127437
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