Sports Medicine

Peak strain dispersion as a nonlinear mediator in HFpEF: Unraveling subtype-specific pathways via SHAP-augmented ensemble modeling.

BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) represents a heterogeneous syndrome with diverse pathophysiological mechanisms and limited therapeutic options. Peak strain dispersion (PSD) has emerged as a potential mediator in HFpEF pathophysiology. This study aimed to identify distinct HFpEF subtypes and investigate PSD's subtype-specific mediating pathways. METHODS: This pros...

Plasma proteomics biomarkers for predicting anti-tuberculosis drug-induced liver injury: A comprehensive assessment.

AIMS: This study aims to identify predictive plasma protein biomarkers for anti-tuberculosis drug-induced liver injury (ATB-DILI) and develop machine learning models for pre-treatment risk stratification. METHODS: In this retrospective nested case-control study, proteomic profiling of pre-treatment plasma from 24 patients (12 ATB-DILI, 12 controls) identified differentially expressed proteins, whi...

Next-generation lung-cancer-on-a-chip: toward personalized therapy, AI, and CRISPR-driven models.

Lung-cancer-on-a-chip (LCOC) technologies have advanced rapidly, yet most models evaluate mechanical strain, patient-derived tumors, multi-organ inter...

Can OMFS experts distinguish AI from human manuscripts? A double-blind evaluation using ChatGPT-4.

OBJECTIVE: As generative AI tools like ChatGPT-4 gain traction in academic writing, questions arise regarding their credibility, scientific depth, and...

Bergenin attenuates traumatic brain injury via inhibition of microglial PFKFB3-driven glycolytic-inflammatory crosstalk.

Traumatic brain injury (TBI) initiates a complex cascade of neuroinflammatory and metabolic disturbances that exacerbate neuronal loss and neurologica...

Unlocking 2D/3D+T myocardial mechanics from cine MRI: a mechanically regularized space-time finite element correlation framework.

Accurate and biomechanically consistent quantification of cardiac motion remains a major challenge in cine MRI analysis. While classical feature-track...

Metabolic engineering of Pichia pastoris for high-efficiency production of branched-chain amino acids -enriched single-cell protein.

Branched-chain amino acids (BCAAs), including leucine, isoleucine, and valine, are essential nutrients for animals that must be obtained from the diet...

FGA Serves as a Potential Diagnostic Marker and Therapeutic Target for Elderly Acute Kidney Injury.

To identify potential biomarkers and explore the underlying mechanisms of elderly acute kidney injury (e-AKI), we performed integrative plasma proteom...

Strain-specific metabolic endpoints and predictive phase classification in gnotobiotic kimchi fermentation.

Fermentation is driven by dynamic interactions between substrates and microbial communities. However, the complexity of natural consortia limits their...

Predicting activities of daily living at discharge in stroke patients using rehabilitation robot training-induced functional connectivity.

BACKGROUND: Predicting activities of daily living (ADL) in stroke patients optimizes discharge planning, which relies on accurate functional assessmen...

Mitigating psychological stress-induced cardiac injury: The impact of CB2R agonists on endoplasmic reticulum stress and mitophagy.

BACKGROUND: Psychological stress is a recognized contributor to cardiac injury and disease; however, the molecular mechanisms underlying this relation...

Acute kidney injury: Detection, risk stratification, and predictive biomarkers.

BACKGROUND: Acute kidney injury (AKI) is a complex multifactorial syndrome characterized by a rapid decline in kidney function, frequently observed in...

From bench to bedside: The clinical relevance of atrial electrical remodeling in atrial fibrillation therapy.

Atrial electrical remodeling spans molecular, electrical, and structural alterations that shorten refractoriness, facilitate reentry, and ultimately c...

Physical exercise protects cardiovascular fitness in long-term spaceflight: what have we learned?

As space exploration advances into the era of deep space exploration, humanity faces unprecedented challenges in maintaining astronaut health, not onl...

Machine learning prediction for identifying individuals requiring rotator cuff repair: Shoulder muscle strength and questionnaires as the related factors.

BackgroundRotator cuff tears, a common cause of shoulder pain, often require surgery when conservative treatment fails. Arthroscopic repair is standar...

Spoof Surface Plasmon Polariton Enabled Flexible e-Skin for Cross-Media Proximity Sensing and Material Identification.

With the increasing deployment of intelligent robotics in medical rehabilitation and elderly care, sensing modalities and functionalities eventually b...

Adolescents with non-suicidal self-injury exhibit increased pain empathic neural reactivity and personal distress to physical but not affective pain.

BACKGROUND: Non-suicidal self-injury (NSSI) in adolescents represents a critical public health issue. While symptomatic links between NSSI and alterat...

Synergistic mitochondrial homeostasis regulation and cholinergic circuits reconstruction via a one-step synthesized multifunctional hydrogel facilitates spinal cord injury repair.

Neural Stem Cells (NSCs) possess significant potential to form new neural networks. However, following spinal cord injury (SCI), mitochondrial dysfunc...

Shared inflammation in takotsubo syndrome and sepsis: Lipocalin-2 mediates neutrophil infiltration and cardiac damage.

BACKGROUND: Takotsubo syndrome (TTS) and sepsis often co-occur with poor outcomes, yet their underlying molecular mechanisms remain to be elucidated. ...

Letter to the editor regarding "ChatGPT delivers satisfactory responses to the most frequent questions on meniscus surgery".

BACKGROUND: This letter addresses methodological aspects of a study that evaluated a large language model's responses to frequently asked patient ques...