Latest AI and machine learning research in stem cell research for healthcare professionals.
Background: Cognitive behavioural therapy (CBT) is the most frequently used and recommended therapy program for mental health conditions, including for eating disorders. Despite decades of use, little is known about how change is produced in CBT across mental illnesses, and there has been no empirical validation of the causal structure of change for CBT treatment of eating disorders. Progress in o...
Background Childhood neurodegenerative disorders are usually rare, genetic, and life-limiting. Whilst targeted approaches present huge potential, significant hurdles include disease rarity, geographical dispersion of patients, funding, clinical trial design, and execution. Crucially, the paucity of robust biomarkers and objective measures of disease progression hampers evaluation of efficacy, drug...
Key regulators of neural network activity in multiple advanced cognitive processes and essential components of the blood-brain barrier, astrocytes con...
The human immune system is composed of [~]30-50 distinct cell types, each of which can exist in different states of activation or differentiation. Ind...
Background The faecal immunochemical test (FIT) is central to triaging symptomatic patients with suspected colorectal cancer (CRC) in UK primary care,...
Despite major advances in the study of cerebellar neurogenesis, cerebellar angiogenesis during embryogenesis remains poorly described. Recent advances...
Recent visual place recognition (VPR) studies have increasingly relied on large-scale datasets to train more robust and discriminative models. Althoug...
Classification of research articles according to translational research stages enables funding bodies, academic and medical institutes, and policymake...
Background: Motor complications, such as motor fluctuations and Levodopa-induced dyskinesias (LID), significantly impair quality of life in persons wi...
Background: Lewy body diseases (LBD) collectively share alpha-synuclein Lewy pathology, yet present wide clinical heterogeneity, with overlapping moto...
Background Pretreatment prediction of primary resistance to anti-PD-(L)1 therapy in advanced non-small-cell lung cancer (NSCLC) remains an unmet clini...
BackgroundHealth care organizations are increasingly required to make strategic decisions about artificial intelligence (AI) systems before their clin...
In vivo CAR-T cell therapy eliminates manufacturing complexities associated with ex vivo autologous approaches, but safety concerns have limited adopt...
Background: Artificial intelligence (AI), including generative and foundation-based methods, has rapidly expanded within medical imaging research. How...
Aging is caused, fully in large part, by the progressive accumulation of damage, yet quantifying age-related damage across tissues and conditions rema...
Introduction: Generative artificial intelligence (AI) can produce realistic clinical scenarios on demand and deliver immediate, individualized feedbac...
Background: Existing electronic frailty indices (eFI) are typically based on structured data and designed for older adults. We developed an eFI that i...
Immune checkpoint inhibitors (ICI) are central to the treatment of metastatic clear cell renal cell carcinoma (ccRCC), yet only a subset of patients d...
Chromatin is organized into self-interacting topologically associating domains partitioned by boundary elements that insulate adjacent domains and res...
Single-cell RNA sequencing provides high-resolution snapshots of cellular states but lacks direct information about transcriptional dynamics. Metaboli...