Latest AI and machine learning research in stem cell research for healthcare professionals.
Background: Caspase-3 and -7 are key effector caspases in the apoptotic pathway, a form of programmed cell death, and their activities serve as a well-established biomarker for evaluating environmental chemical toxicity and informing chemical risk assessment. Loss of mitochondrial membrane potential is a key event in the activation of Caspase-3/7 signaling and the subsequent induction of apoptosis...
Recent spatial multi-omics technologies enable the simultaneous in situ profiling of multiple omics modalities on the same tissue section; however, they face challenges in experimental complexity and high costs. This technical limitation can be circumvented by diagonal integration methods, which integrate omics data from different modalities. However, existing single-cell diagonal integration appr...
The zebrafish yolk sac (YS) is traditionally viewed as a nutrient reservoir. By reconstructing the complete progression of embryonic neural developmen...
Maternal transcripts are stored in the oocyte cytoplasm during oogenesis and play a pivotal role in early embryonic development after fertilization. H...
The genomic basis of limb adaptations in tetrapods is thought to be largely driven by changes in gene regulation. However, the mechanisms by which reg...
Objective Accurate prognostication of recurrence risk in HR+/HER2- early breast cancer is central for therapeutic decision-making, including identifyi...
Assigning functions to genes remains a major challenge in biology, as a large fraction of genes remain unannotated despite the availability of complet...
Introduction Obstructive lung diseases (OLDs) are responsible for high rates of illness and death worldwide. Inflammation, chronic airflow limitation,...
Background Artificial intelligence-enhanced electrocardiography (AI-ECG) enables scalable, low-cost cardiac dysfunction screening, but existing models...
Understanding and modeling how a single human genome concurrently encodes gene regulatory programs for thousands of cell types remains a central chall...
Liver sinusoidal endothelial cells (LSECs) are increasingly recognized as a critical yet underexplored cell type in anti-fibrotic drug development. Th...
Cells that store lipids for other cells or organs can contain ''giant'' or large lipid droplets (LLDs) greater than 2 m in diameter. In this study, hu...
Treatment of advanced head and neck squamous cell carcinoma (HNSCC) often involves radiotherapy combined with chemotherapy, targeted therapy, or immun...
How combinatorial cell signaling controls cellular decisions in the face of crosstalk is a fundamental problem in biology. A key open question is whet...
Introduction: Infectious and wound-healing complications after colorectal surgery often increase the complexity of local care and the need for special...
Drug repurposing offers a cost-effective strategy to accelerate therapeutic discovery, but most computational approaches fail to model noncoding genet...
Tuberculosis (TB) continues to pose a significant global public health challenge with substantial morbidity and mortality. Current TB biomarkers lack ...
The Post-baccalaureate Research Education Program (PREP), established by the National Institute of General Medical Sciences (NIGMS) at the National In...
Zebrafish embryos are a valuable model for drug discovery due to their optical transparency and genetic similarity to humans. However, current evaluat...
Neuroectoderm-derived tissues are highly metabolically active and exhibit minimal regenerative turnover, rendering them uniquely vulnerable to age-rel...