Stem Cell Research

From Multi-Omics to Visualization and Beyond: Bridging Micro and Macro Insights in CAR-T Cell Therapy.

Chimeric antigen receptor T (CAR-T) cell therapies, a cornerstone of immunotherapy, have demonstrate...

Impact of dental pulp cells-derived small extracellular vesicles on the properties and behavior of dental pulp cells: an in-vitro study.

BACKGROUND: Dental pulp cells-derived small extracellular vesicles (DPCs-sEVs) had shown immunomodul...

Polysorbates and poloxamer rescue filter-induced serotype-dependent loss of AAVs.

Adeno-associated viruses (AAVs) are the leading viral vector for in-vivo gene therapy, and their use...

Simultaneous initiation of dolutegravir-based antiretroviral therapy and once-weekly rifapentine and isoniazid for tuberculosis prevention in antiretroviral-naive people with HIV: an open-label, non-randomised, phase 1/2 trial.

BACKGROUND: Tuberculosis preventive treatment with 3 months of once-weekly isoniazid (900 mg) and ri...

In vitro effects of laser-activated irrigation methods on apical extrusion of indocyanine green mediated photodynamic therapy.

OBJECTIVES: This study aimed to compare the effects of different laser-activated irrigation (LAI) me...

The risks and benefits of AI therapy tools.

Efficacy and safety of first-line CDK4/6 inhibitors plus AI therapy for patients with HR +/HER2- advanced breast cancer: a network meta-analysis.

BACKGROUND: CDK4/6 inhibitors plus aromatase inhibitors (AI) significantly improve the therapeutic e...

Step up to triple therapy versus switch to dual bronchodilator therapy in patients with COPD on an inhaled corticosteroid/long-acting β-agonist: post-hoc analyses of KRONOS.

BACKGROUND: In people with chronic obstructive pulmonary disease (COPD) on inhaled corticosteroid/lo...

Predicting the outcome of psychological treatments for borderline personality disorder and posttraumatic stress disorder: a machine learning approach to predict long-term outcome of Narrative Exposure Therapy vs. Dialectical Behavioral Therapy based treatment.

: A comorbidity between Borderline Personality Disorder (BPD) and Posttraumatic Stress Disorder (PTS...

Branding a New Technological Outlook for Future Orthopaedics.

Orthopedics is undergoing a transformative shift driven by personalized medical technologies that en...

Precise Electromagnetic Modulation of the Cell Cycle and Its Applications in Cancer Therapy.

Precise modulation of the cell cycle via electromagnetic (EM) control presents a groundbreaking appr...

Gradient-driven deep penetration of self-electrophoretic nanoparticles in acidic tumor microenvironments for enhanced antitumor therapy.

Difficulty of nanomedicines to effectively penetrate the tumor core and achieve effective killing of...

Modification of the toronto rehabilitation institute-hand function test for integration into robot-assisted therapy: technical validation and usability.

BACKGROUND: Effective rehabilitation of the upper extremity function is vital for individuals recove...

Exploring the complex nature of implementation of Artificial intelligence in clinical practice: an interview study with healthcare professionals, researchers and Policy and Governance Experts.

Artificial Intelligence (AI)-based tools have shown potential to optimize clinical workflows, enhanc...

Evaluation of Hepatic Progenitor and Hepatocyte-Like Cell Differentiation Using Machine Learning Analysis-Assisted Surface-Enhanced Raman Spectroscopy.

Technology has been developed to monitor the differentiation process of human mesenchymal stem cells...

Explainable Machine Learning Models for Colorectal Cancer Prediction Using Clinical Laboratory Data.

IntroductionEarly diagnosis of colorectal cancer (CRC) poses a significant clinical challenge. This ...

Evaluation of the Efficacy of Step-down Therapy with Oral Minocycline for Complicated Pyelonephritis Caused by Extended-Spectrum β-Lactamase-Producing Enterobacterales: A Retrospective Cohort Study.

BACKGROUND: Extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) infections present sig...

Systemic therapy informed self-help and paraprofessional training in a naturalistic setting: study protocol of a digital randomised trial.

BACKGROUND: Multiple studies have shown the efficacy of Systemic Psychotherapy (ST) approaches as a ...

Invited Article: Al guided Dual Antiplatelet Therapy and Anticoagulation.

Artificial intelligence (AI) has emerged as a transformative tool in healthcare through data analysi...

Machine learning-based text mining for cutaneous myiasis and potential value of an accidental maggot therapy for complicated skin and soft tissue infection with sepsis.

BACKGROUND: Cutaneous myiasis, one of the most frequently diagnosed myiasis types, is defined as ski...

Student perceptions of artificial intelligence in Doctor of Physical Therapy Education.

PURPOSE: Health profession education is impacted by developments in artificial intelligence (AI). Wh...