Stem Cell Research

3D chromatin architecture-related genes orchestrate LUAD evolution and therapy resistance: insights from integrative machine learning and spatial single-cell mapping.

BACKGROUND: Lung adenocarcinoma (LUAD) is a prevalent and lethal malignancy. The three-dimensional (3D) chromatin architecture significantly influences tumor progression, yet the contribution of 3D chromatin structure-related genes (3DCRGs) in LUAD remains unclear. This study was designed to explore the role of 3DCRGs in postoperative recurrence of early-stage LUAD, response to Sorafenib therapy i...

Harnessing Artificial Intelligence for Regeneration of Endometrium in Asherman's Syndrome.

BACKGROUND: Asherman's Syndrome or intrauterine adhesions develop due to acquired endometrium damage, resulting in partial to complete dysfunction of the endometrium within the uterine cavity. The pathophysiology of these adhesions is not clear. Still, the widely accepted mechanism for the development of these adhesions is attributed to three different causes: i. iatrogenic or mechanical, includin...

Development, validation, and user-centric evaluation of an interpretable machine learning decision support tool for the preoperative prediction of mild bleeding disorders (MBD-Check): a prospective diagnostic prediction study.

BACKGROUND: Mild bleeding disorders are the most common inherited bleeding disorders, often leading to perioperative haemorrhages. Preoperative screen...

Analysis of health infrastructure and suicide rates in Brazil: a nationwide ecological spatial-temporal study, 2009-2023.

BACKGROUND: Suicide remains a major global health concern and disproportionately affects low- and middle-income countries (LMICs), where socio-economi...

Immersive virtual reality for cognitive rehabilitation in patients who had a stroke: study protocol for a randomised controlled trial.

INTRODUCTION: Poststroke cognitive impairment (PSCI) is a prevalent complication of stroke, characterised by deficits in one or more cognitive domains...

A multimodal deep learning model predicting hyperprogressive disease for PD-1 blockade in advanced hepatocellular carcinoma.

Immune checkpoint inhibitors, particularly antibodies targeting programmed cell death 1 (PD-1), are increasingly used for advanced hepatocellular carc...

Multi-omics integration reveals convergent extracellular matrix remodelling and lipid metabolic reprogramming as central axes of adipocyte differentiation from mouse embryonic stem cells.

Adipogenesis from mouse embryonic stem cells (mESCs) offers a tractable model for dissecting early adipocyte commitment, yet the mechanisms coordinati...

Magnetoelectric microrobots for spinal cord injury regeneration.

Spinal cord injury remains difficult to treat because of the intrinsically limited regenerative capacity of neurons. Although neural progenitor cell (...

Artificial Intelligence Discontinuation Effects (AI-DICE): An Emerging Phenomenon in Mental Health Applications.

Artificial intelligence (AI) has emerged as a powerful tool for fostering positive behavior change and enhancing mental health support. However, the a...

Construction of liver organoid models by hepatobiliary differentiation from human induced pluripotent stem cells: state of the art, challenges and improving strategies.

Physiologically relevant liver models are essential for advancing hepatic disorder research, especially for disease modeling and drug development, yet...

Landscape of T-cell bispecific antibodies in cancer therapy: therapeutic strategies, challenges and future prospection.

T-cell bispecific antibodies (TCBs), a specialized subclass of bispecific antibodies (BsAbs), are engineered to simultaneously engage T cells and tumo...

Comorbidities for Predicting Progression Independent of Relapse Activity in Multiple Sclerosis Treated With B-Cell Depletion.

BACKGROUND: Progression independent of relapse activity (PIRA) has been shown to account for a majority of the disability accumulation in relapsing-re...

Machine learning in tissue engineering: a comprehensive review of applications, challenges, and prospects.

Tissue engineering, rooted in cell biology and materials science, focuses on repairing or replacing injured tissues and organs, offering groundbreakin...

Is it time to 'cap and trade' credits for research-funding proposals?

Integrative multi-omics analysis identifies a circadian rhythm-associated gene signature for prognosis and therapeutic stratification in lung adenocarcinoma.

BACKGROUND/OBJECTIVES: Circadian rhythm disruption is increasingly implicated in tumor progression and therapy resistance. However, its prognostic val...

Students' Perspectives on Digital Psychotherapy-Possible Solutions for Digital Inpatient-Like Care Concepts: Qualitative Interview Study.

BACKGROUND: The demand for mental health treatment is increasing, while the availability of treatment remains insufficient to meet the rising demand. ...

Beyond Training: Systems Framework for Sustainable Health Informatics Investment in Africa.

Across Africa, substantial investment has built national health information systems (HISs), including the surveillance platforms, reporting tools, and...

Skill Information Representation Imitation Learning for Long-Horizon Dexterous Robot Micromanipulation of Deformable Cell.

Robots performing collaborative long-horizon dexterity cell micromanipulation tasks are challenging and practically significant, such as peeling cell ...

Evaluation of a Collaborative Telehealth Model for Eye Care Between Ophthalmology and Optometry in Western Australia.

OBJECTIVE: Recent advances in technology and the impact of COVID-19 have expanded the adoption of digital health. Synchronous collaborative telehealth...

Professional Ethics in Dietetics: A Global Document Analysis of Codes of Ethics and Conduct.

BACKGROUND: As dietitians actively engage in sectors beyond healthcare, practitioners are expected to uphold ethical standards that reflect both indiv...