Stem Cell Research

Digital Skills Assessments in Occupational Therapy: A Scoping Review.

IMPORTANCE: Digital skills are increasingly essential in performing daily activities. Occupational therapy practitioners require valid and accessible assessments to evaluate and address these competencies. However, the availability and quality of these assessments have not been established. OBJECTIVE: To identify and map existing, accessible, low-cost measures to assess digital skills in adult pop...

Integrated approaches to preventing macrovascular complications in type 2 diabetes mellitus: Advances in secondary prevention.

BACKGROUND: Type 2 diabetes mellitus (T2DM) substantially increases the risk of macrovascular complications, including coronary artery disease, cerebrovascular disease and peripheral arterial disease, which collectively represent the leading causes of morbidity and mortality among affected individuals. Evidence from clinical trials has demonstrated that intensive glycemic control alone provides li...

An AI Tutorial for Speech and Language Therapists: Translating Concepts From the AI Literature Into Accessible Knowledge and Clinically Relevant Applications.

BACKGROUND: Artificial Intelligence (AI) is increasingly discussed as a tool that can support speech and language therapy (SLT). However, clinical ado...

Tailored AI ethics: Enacting geriatric care with AI-based patient monitoring.

Artificial intelligence (AI) systems are increasingly integrated into clinical practice, where they demonstrate potential to mitigate adverse events t...

Addressing multiple pregnancies in in vitro fertilization-embryo transfer: Current status, challenges, and solutions.

With the rising global incidence of infertility and the growing proportion of infants conceived via in vitro fertilization-embryo transfer (IVF-ET), m...

Examining media coverage of ethical dimensions of advanced algorithmic technology.

The rapid integration of artificial intelligence, machine learning, and data science into daily life raises ethical concerns and stimulates discussion...

Regenerative and Stem Cell-Based Therapies for Arthritis: Harnessing Mesenchymal Stem Cells, Exosomes, and Bioengineered Scaffolds for Functional Joint Repair.

Arthritis, encompassing degenerative disorders such as osteoarthritis (OA) and autoimmune diseases like rheumatoid arthritis (RA), remains a leading c...

Nanozymes for Liver Disease Therapy: Advances in Catalytic Activity, Targeting Strategies, and Clinical Translation.

Natural and artificial enzymes have emerged as promising candidates for biomedical applications, possessing the potential to address redox imbalances ...

Single-nucleus multi-omics dissection of dysregulated trophoblast development and disrupted immune microenvironment in complete hydatidiform moles.

Hydatidiform mole (HM) is driven by aberrant trophoblast proliferation, disrupting embryonic development and leading to pregnancy loss with increased ...

Ethics training competencies and leadership enable responsible AI in hospitality and tourism.

Artificial intelligence (AI) is reshaping the service industries, increasing demand for fair, transparent, and ethical systems. This study examined ho...

Impact of quality routine health data utilisation on health service delivery outcomes in low-income and middle-income countries: a systematic review protocol.

BACKGROUND: Evidence-based decision-making in healthcare relies heavily on routine health information. However, in many low-income and middle-income c...

Transcriptome-based high-frequency recurrence index predicts frequent recurrence in non-muscle-invasive bladder cancer after Bacillus Calmette-Guérin therapy.

BACKGROUND: High-frequency recurrence (HfR, ≥ 2 recurrences) in non-muscle-invasive bladder cancer (NMIBC) poses a significant clinical burden. Curren...

Materiobiology-guided regulation of mesenchymal stromal cell fate for aging-related diseases: From basic parameter design to clinical application.

Mesenchymal stromal cells (MSCs) possess potent immunomodulatory, pro-angiogenic, and regenerative capacities, offering broad clinical promise in rege...

Molecular basis of muscle wasting and emerging therapeutic strategies targeting degenerative muscle disorders.

Muscle degenerative conditions, including sarcopenia, muscular dystrophies, and trauma-induced muscle loss, severely compromise mobility, metabolism, ...

Deep Learning-Enhanced Biomarker Interpretation on Cytology Cell Blocks - Foundations and Emerging Opportunities in Spatial Pathobiology.

Cytology cell block specimens are essential diagnostic materials in patients with advanced-stage malignancy and often represent the only available sub...

Normalized QRS Duration by LV Dimension: Eliminating Sex-Specific Differences and Predicting Cardiac Resynchronization Therapy Outcomes.

BACKGROUND: Increasing evidence shows sex-specific differences in the efficacy of cardiac resynchronization therapy (CRT). Without a clear cardiac rat...

Radiopharmaceuticals: Status, Regulatory Landscape and Future Perspective.

Radiopharmaceuticals are biologically active molecules labeled with radionuclides that have advanced the possibility of the nuclear medicine. They sup...

Deep learning-assisted tumor radiomic dynamics on MRI predict pathological complete response in HCC undergoing immune-based therapy followed by hepatectomy.

BACKGROUND AIMS: Pathological complete response (pCR) following conversion therapy for initially unresectable hepatocellular carcinoma (uHCC) remains ...

Ryanodine receptor 2 mutations in catecholaminergic polymorphic ventricular tachycardia: From molecular mechanisms to precision medicine.

Catecholaminergic polymorphic ventricular tachycardia is a classic example of the successful transfer of genetic cardiology from gene discovery to imp...

AI-driven quality control of cell-based ATMPs: automated, accurate, and affordable.

BACKGROUND AIMS: The production of neuroepithelial stem (NES) cells, a promising therapeutic candidate for neurological conditions such as stroke and ...