Stem Cell Research

Regulatory T cells and matrix-producing cancer associated fibroblasts contribute on the immune resistance and progression of prognosis related tumor subtypes in ccRCC.

Clear cell renal cell carcinoma (ccRCC) is a prevalent malignant tumor in the field of urology. The effect of cell heterogeneity on the prognosis and reaction to treatment of ccRCC in large populations is still unclear. By analyzing public single cell RNA-sequencing and bulk RNA-sequencing data with the Scissor algorithm, we have identified three distinct prognosis related cancer cell subtypes whi...

Validation of an AI-enabled exome/transcriptome liquid biopsy platform for early detection, MRD, disease monitoring, and therapy selection for solid tumors.

Effective clinical management of patients with cancer requires highly accurate diagnosis, precise therapy selection, and highly sensitive monitoring of disease burden. Caris Assure is a multifunctional blood-based assay that couples whole exome and whole transcriptome sequencing on plasma and leukocytes with advanced machine learning techniques to satisfy all three clinical testing needs on one pl...

Computed tomography-based radiomics predicts prognostic and treatment-related levels of immune infiltration in the immune microenvironment of clear cell renal cell carcinoma.

OBJECTIVES: The composition of the tumour microenvironment is very complex, and measuring the extent of immune cell infiltration can provide an import...

The impact of an AI-focused ethics education program on nursing students' ethical awareness, moral sensitivity, attitudes, and generative AI adoption intention: a quasi-experimental study.

BACKGROUND: The integration of Generative artificial intelligence (GAI) into healthcare is rapidly evolving, necessitating ethical preparedness among ...

Deep learning for automated segmentation of radiation-induced changes in cerebral arteriovenous malformations following radiosurgery.

BACKGROUND: Despite the widespread use of stereotactic radiosurgery (SRS) to treat cerebral arteriovenous malformations (AVMs), this procedure can lea...

MRI's evolving role in rectal cancer in the era of personalized medicine.

Recent decades have seen great advances in the diagnosis and management of rectal cancer, and magnetic resonance imaging (MRI) has become pivotal for ...

Boosting Checkpoint Blockade Immunotherapy with T Cell Membrane Redox Homeostasis Regulation and Deep Learning Enhanced NIR-II Imaging.

Immune checkpoint blockade therapy has revolutionized clinical oncotherapy by intercepting immunosuppressive pathways in tumor tissues. Nevertheless, ...

Genetic Deconvolution of Embryonic and Maternal Cell-Free DNA in Spent Culture Medium of Human Preimplantation Embryo Through Deep Learning.

Noninvasive preimplantation genetic testing for aneuploidy based on embryonic cell-free DNA (cfDNA) released in spent embryo culture media (SECM) has ...

Optogenetic neural spheroids excite primary neural network.

Optical stimulation ofneurons requires prior transfection with light gated ion channels. This additional step brings complexity and requires optimizat...

Advancing Design Strategy of PROTACs for Cancer Therapy.

Proteolysis targeting chimeras (PROTACs) have emerged as a groundbreaking class of anticancer therapeutics. These bifunctional molecules harness the e...

Personalizing Responsive Neurostimulation for Epilepsy.

Over the past 20 years, responsive neurostimulation (RNS), a closed-loop device for treating certain forms of drug-resistant focal epilepsy, has becom...

Comparison of a novel gamified binocular therapy and standard monocular patching therapy in treating unilateral amblyopia in young children: a prospective, multicenter, randomized controlled trial.

BACKGROUND: Amblyopia is a leading cause of visual impairment in children, and conventional treatments often encounter challenges related to poor comp...

Adolescent lumbar disc herniation: etiology, diagnosis, and treatment options.

Adolescent lumbar disc herniation (ALDH) is a type of disease with a much lower incidence than adult lumbar disc herniation (LDH), which has a trend o...

Biomanufacturing in low Earth orbit: A paradigm shift.

This perspective article explores the transformative potential of biomanufacturing in low Earth orbit (LEO) for regenerative medicine. Building on key...

Droplet microfluidics integrated with machine learning reveals how adipose-derived stem cells modulate endocrine response and tumor heterogeneity in ER breast cancer.

Approximately 70% of breast cancer (BC) diagnoses are estrogen receptor positive (ER) with ∼40% of ER BC patients presenting resistance to endocrine ...

Enhancing image quality in fast neutron-based range verification of proton therapy using a deep learning-based prior in LM-MAP-EM reconstruction.

This study investigates the use of list-mode (LM) maximum(MAP) expectation maximization (EM) incorporating prior information predicted by a convolutio...

Multifunctional nanophotonic photoacoustic biosensors: a new era in molecular imaging-guided deep-tissue cancer monitoring.

Monitoring cancer therapy is difficult because of restricted imaging depth, inadequate molecular specificity, and delayed response evaluation. Moreove...

Unsupervised Machine Learning-Based Process Analytical Tools for Near Real-Time Cell Morphology Analysis During CAR-T Cell Manufacturing.

Cell therapies like Chimeric Antigen Receptor (CAR)-T cell therapy deliver living cells to patients as active pharmaceutical ingredients. Manufacturin...

Machine learning-based models for outcome prediction in skull base and spinal chordomas: a systematic review and meta-analysis.

BACKGROUND: Chordomas are primary bone lesions originating from embryonic notochord remnants, most commonly developing along the skull base and spine....

Stereotactic Body Radiation Therapy for Primary Renal Cancer and Genetic Markers of Response: A Phase 2 Trial.

Controlled outcome assessment of radiotherapy for primary renal cell carcinoma (RCC) remains limited, particularly regarding its impact on ipsilateral...