Stem Cell Research

In vitro processes alter the embryonic disc epigenome and transcriptome in the pre-implantation elongated bovine embryo†.

The objective was to quantify the effect of the in vitro procedures on the epigenome and transcriptome of the embryonic disc (ED) and extra-embryonic membranes (EEM) of day 15 in vitro produced (IVP) conceptuses compared to in vivo (IVV) counterparts. IVP embryos (n = 7) were cultured serum-free until transfer at day 7. IVV embryos (n = 9) were conceived by artificial insemination. Animals were fl...

3D bioprinting in tissue engineering: current state-of-the-art and challenges towards system standardization and clinical translation.

Over the past decade, 3D bioprinting has made significant progress, transforming into a key innovation in tissue engineering. Despite the early strides, critical challenges remain in 3D bioprinting that must be addressed to accelerate clinical translation. In particular, there is still a long way to go before functionally-mature, clinically-relevant tissue equivalents are developed. Current limita...

Machine learning application for bleeding risk prediction in patients with atrial fibrillation treated with oral anticoagulation.

Atrial fibrillation (AF) is a prevalent cardiac arrhythmia associated with a significantly increased risk of systemic thromboembolism and stroke. Anti...

Integrating Machine Learning Algorithms to Construct a Triaptosis-Related Prognostic Model in Melanoma.

INTRODUCTION: Melanoma is a highly aggressive skin cancer that accounts for a disproportionate number of skin cancer-related deaths due to early metas...

Simulation-free workflow for lattice radiation therapy using deep learning predicted synthetic computed tomography: A feasibility study.

PURPOSE: Lattice radiation therapy (LRT) is a form of spatially fractionated radiation therapy that allows increased total dose delivery aiming for im...

AI Mimicking and Interpreting Humans: Legal and Ethical Reflections.

The increasing prevalence of AI in all facets of human lives raises profound questions of ethics, policy, and law. Interactions with AI in situations ...

Multiscale-fusion models with genomic, topological and pathomic features to predict response to radiation therapy for non-small cell lung cancer patients.

Artificial intelligence models with biomarkers to predict treatment responses to radiation would be necessary to maximise the treatment outcomes of in...

Adipose-Derived Mesenchymal Stem Cells Accelerate Diabetic Foot Ulcer Healing by Promoting Macrophage M2 Polarization Through Downregulation of and .

PURPOSE: Macrophage polarization plays a critical role in the chronic wound healing of diabetic foot ulcers (DFU). Recent studies have shown that adip...

Monitoring of Early Skin Reactions by Optical Coherence Tomography and Dermatoscopy in Patients Receiving Radiation Therapy for Head and Neck Cancer.

PURPOSE: Patients with head and neck cancer undergoing radiation therapy (RT) may experience pronounced acute skin reactions. We tested whether optica...

Intraoperative hypotension during robotic-assisted radical prostatectomy: A randomised controlled trial comparing standard goal-directed fluid therapy with hypotension prediction index-guided goal-directed fluid therapy.

BACKGROUND: Robot-assisted radical prostatectomy (RARP) represents the leading application of robotic surgery in the treatment for prostate cancer wit...

What does evolution make? Learning in living lineages and machines.

How does genomic information unfold, to give rise to self-constructing living organisms with problem-solving capacities at all levels of organization?...

The potential role of AI in research priority setting exercises.

To help achieve the goals of accountability and research excellence, funding organisations often utilise evidence from research priority setting exerc...

Perspectives of Artificial Intelligence Use for In-House Ethics Checks of Journal Submissions.

Artificial intelligence (AI) has shown its ability to transform academic writing and publishing. It offers significant benefits, including enhancing e...

Recent Advancements in Smart Hydrogel-Based Materials in Cartilage Tissue Engineering.

Cartilage tissue engineering (CTE) is an advancing field focused on developing biomimetic scaffolds to overcome cartilage's inherently limited self-re...

The Effects of Robot-Assisted Therapy on Upper Extremity Functions and Functional Independence in Geriatric Individuals With Chronic Stroke: A Randomized Controlled Study.

AimStroke often leads to impaired motor functions, particularly in upper extremities, making functional recovery essential for quality of life and ind...

Prediction of Ligand-Receptor Interactions Based on CatBoost and Deep Forest and Their Application in Cell-Cell Communication Analysis.

Cell-to-cell communication (CCC) is prominent for cell growth and development as well as tissue and organ formation. CCC inference can help us to deep...

Development and validation of the Immune Profile Score (IPS), a novel multiomic algorithmic assay for stratifying outcomes in a real-world cohort of patients with advanced solid cancer treated with immune checkpoint inhibitors.

BACKGROUND: Immune checkpoint inhibitors (ICIs) have transformed the oncology treatment landscape. Despite substantial improvements for some patients,...

A solution to the postantibiotic era: phages as precision medicine.

Antibiotic-resistant bacterial infections pose a significant global health challenge. Phage therapy provides a promising alternative to antibiotics th...

It Takes More Than Enthusiasm: The Missing Infrastructure to Unlock AI's Potential in Medical Education.

Generative artificial intelligence (AI), including large language models (LLMs), is rapidly transforming health care delivery, yet medical education r...

18F-FDG PET/CT Radiomics for Predicting Therapy Response in Primary Mediastinal B-Cell Lymphoma: A Bi-Centric Pilot Study.

PURPOSE: This bi-centric pilot study investigates the predictive value of pre-treatment [F]FDG PET/CT radiomics for assessing therapy response in prim...