Stem Cell Research

Increasing motor cortex activation during grasping via novel robotic mirror hand therapy: a pilot fNIRS study.

BACKGROUND: Mirror therapy (MT) has been used for functional recovery of the affected hand by providing the mirrored image of the unaffected hand movement, which induces neural activation of the cortical hemisphere contralateral to the affected hand. Recently, many wearable robots assisting the movement of the hand have been developed, and several studies have proposed robotic mirror therapy (RMT)...

A Research Ethics Framework for the Clinical Translation of Healthcare Machine Learning.

The application of artificial intelligence and machine learning (ML) technologies in healthcare have immense potential to improve the care of patients. While there are some emerging practices surrounding responsible ML as well as regulatory frameworks, the traditional role of research ethics oversight has been relatively unexplored regarding its relevance for clinical ML. In this paper, we provide...

Magnetic Biohybrid Microrobot Multimers Based on Cells for Enhanced Targeted Drug Delivery.

Magnetic micro-/nanorobots have been regarded as a promising platform for targeted drug delivery, and tremendous strategies have been developed in rec...

PRCTC: a machine learning model for prediction of response to corticosteroid therapy in COVID-19 patients.

Corticosteroid has been proved to be one of the few effective treatments for COVID-19 patients. However, not all the patients were suitable for cortic...

Integrated Machine Learning and Bioinformatic Analyses Constructed a Novel Stemness-Related Classifier to Predict Prognosis and Immunotherapy Responses for Hepatocellular Carcinoma Patients.

Immunotherapy has made great progress in hepatocellular carcinoma (HCC), yet there is still a lack of biomarkers for predicting response to it. Cancer...

An RNA-based theory of natural universal computation.

Life is confronted with computation problems in a variety of domains including animal behavior, single-cell behavior, and embryonic development. Yet w...

Transient hypercalcemia followed by hypocalcemia in a preterm infant after maternal magnesium sulfate therapy.

Maternal use of magnesium sulfate has been associated with neonatal hypocalcemia and bone changes. We report the case of a preterm male infant who pre...

Manipulation of Multiple Cell-Cell Interactions by Tunable DNA Scaffold Networks.

Manipulation of cell-cell interactions via cell surface engineering has potential biomedical applications in tissue engineering and cell therapy. Howe...

Safe and Ethical Artificial Intelligence in Radiotherapy - Lessons Learned From the Aviation Industry.

Ethical artificial intelligence (AI) frameworks can be the catalyst in improving the safety and wellbeing of people when developing AI systems. In 202...

The sustainability of upper limb robotic therapy for stroke survivors in an inpatient rehabilitation setting.

PURPOSE: To investigate the sustainability of Robot-assisted upper limb therapy (RT-UL) as part of routine occupational therapy and physiotherapy clin...

Molecular Biology in Treatment Decision Processes-Neuro-Oncology Edition.

Computational approaches including machine learning, deep learning, and artificial intelligence are growing in importance in all medical specialties a...

Profiling epigenetic age in single cells.

DNA methylation dynamics emerged as a promising biomarker of mammalian aging, with multivariate machine learning models ('epigenetic clocks') enabling...

AI ethics in computational psychiatry: From the neuroscience of consciousness to the ethics of consciousness.

Methods used in artificial intelligence (AI) overlap with methods used in computational psychiatry (CP). Hence, considerations from AI ethics are also...

Compensating the cell-induced light scattering effect in light-based bioprinting using deep learning.

Digital light processing (DLP)-based three-dimensional (3D) printing technology has the advantages of speed and precision comparing with other 3D prin...

Robotic high-throughput biomanufacturing and functional differentiation of human pluripotent stem cells.

Efficient translation of human induced pluripotent stem cells (hiPSCs) requires scalable cell manufacturing strategies for optimal self-renewal and fu...

Using systems thinking methodologies to address health care complexities and evidence implementation.

BACKGROUND: Despite health care advances, artificial intelligence and government interventions aiming to improve the health and wellbeing of citizens,...

The Effects of Over-Ground Robot-Assisted Gait Training for Children with Ataxic Cerebral Palsy: A Case Report.

Poor balance and ataxic gait are major impediments to independent living in ataxic cerebral palsy (CP). Robot assisted-gait training (RAGT) has been s...

Abnormal synergistic gait mitigation in acute stroke using an innovative ankle-knee-hip interlimb humanoid robot: a preliminary randomized controlled trial.

Abnormal spasticity and associated synergistic patterns are the most common neuromuscular impairments affecting ankle-knee-hip interlimb coordinated g...

Personalized Cell Therapy for Patients with Peripheral Arterial Diseases in the Context of Genetic Alterations: Artificial Intelligence-Based Responder and Non-Responder Prediction.

Stem/progenitor cell transplantation is a potential novel therapeutic strategy to induce angiogenesis in ischemic tissue, which can prevent major ampu...

Demystifying the long noncoding RNA landscape of small EVs derived from human mesenchymal stromal cells.

INTRODUCTION: The regenerative capacity of mesenchymal stromal cells or medicinal signaling cells (MSCs) is largely mediated by their secreted small e...