Steroids

Heat shock protein-mediated remodeling of the bone immune microenvironment: mechanisms and precision therapeutic strategies for osteoporosis.

BACKGROUND: Osteoporosis is a systemic bone disorder marked by reduced bone mass and deteriorating bone microstructure, commonly associated with inflammation, oxidative stress, and imbalances in immune homeostasis. Among the key mechanisms underlying Osteoporosis progression, disruption of the bone immune microenvironment has emerged as a critical scientific issue. Heat shock proteins (HSPs), as h...

Integrating Molecular Pathology, Tumor Microenvironment, and Novel Therapies to Overcome Resistance in Glioblastoma.

Glioblastoma multiforme (GBM) represents the most aggressive primary brain tumor in adults, characterized by significant heterogeneity, rapid progression, and resistance to existing therapies. Conventional therapies provide minimal survival advantages due to recurrence influenced by glioma stem-like cells (GSCs), adaptive signaling pathways, and a highly immunosuppressive tumor microenvironment (T...

Separable, nonlinear, and interactive effects of testosterone and cortisol during status competition in humans: Evidence for the context-dependent dual hormone hypothesis.

The Dual Hormone Hypothesis is a biosocial model that describes the interactive effects of testosterone and cortisol on status-relevant behavior. Unde...

Metabolomic machine learning predictor for the diagnosis of alcohol-associated liver disease.

BACKGROUND: It is urgent to find novel non-invasive biomarkers that can accurately diagnose alcohol-associated liver disease (ALD). The objective of t...

Comment on "Integrating machine learning into fracture liaison services: Toward precision risk stratification in osteoporosis care: A prospective cohort study".

Integrated multi-omics and experimental validation reveal CSK and FBLN1 as key targets of stanozolol in accelerating atherosclerosis.

BACKGROUND: Stanozolol, a synthetic anabolic androgenic steroid (AAS) widely abused to enhance performance, has poorly defined toxicological mechanism...

Clinical Implications and Research Progress of Salivary Biomarkers for Endocrine and Metabolic Disorders.

AIMS: Similar to blood, saliva contains a broad range of biomarkers and may offer a non-invasive, repeatable specimen for endocrine and metabolic asse...

How to quickly determine whether patients with chronic cough need corticosteroid treatment--construction of a predictive model for corticosteroid-responsive cough in chronic cough.

Patients with chronic cough need to undergo a wide range of tests and rely on empirical medication to determine the underlying cause. Corticosteroid-r...

Immune cell delivery platforms for tumor therapy: From empirical approaches to AI-integrated frameworks.

The heterogeneity and immunosuppressive characteristics of the tumor microenvironment present significant challenges to traditional treatment strategi...

Nanomedicine in precision treatment of gastric cancer: current clinical landscape.

Gastric cancer (GC) remains a leading cause of cancer-related mortality worldwide, with therapeutic efficacy often hindered by late-stage diagnosis, c...

ABCA8 drives bone loss via disrupting Th17/Treg imbalance: a novel immunometabolic target for osteoporosis.

BACKGROUND: Osteoporosis is a metabolic bone disease characterized by reduced bone mass and microarchitectural deterioration, with complex involvement...

An explainable machine learning approach to predict fragility fractures and the identification of important features.

In this study, we developed ML algorithms to predict fragility fractures, considering the occurrence of fractures at different skeletal sites, using t...

Landscape of T-cell bispecific antibodies in cancer therapy: therapeutic strategies, challenges and future prospection.

T-cell bispecific antibodies (TCBs), a specialized subclass of bispecific antibodies (BsAbs), are engineered to simultaneously engage T cells and tumo...

Fractal analysis in dentistry: a bibliometric analysis (1991-2024).

OBJECTIVES: This study aims to provide a comprehensive bibliometric mapping of the scientific evolution and research trends of fractal analysis (FA) i...

Organ-Specific Cancer-Associated Fibroblast Subtypes Across the Digestive System Linked to Cancer Hallmarks.

Cancer-associated fibroblasts (CAFs) are major stromal components of the tumor microenvironment (TME) and play diverse roles in gastrointestinal (GI) ...

A risk stratification framework based on ammonia-induced cell death signatures for prognostic assessment and therapeutic insights in colorectal cancer.

BACKGROUND: Ammonia, which was traditionally regarded as a metabolic by-product, has more recently emerged as a crucial regulator of tumor metabolism ...

Targeting Type 2 and Non-type 2 Asthma: Emerging Biologics and Personalized Strategies.

PURPOSE OF REVIEW: Asthma continues to pose a serious global health issue affecting billions of people and causing significant morbidity. It is immuno...

Human and Robot Assistance for Cognitive Load in Younger and Older Adults: Multimodal Within-Subject Experimental Study.

BACKGROUND: Maintaining cognitive efficiency and independence is a central goal of healthy aging. Socially assistive robots (SARs) are increasingly pr...

Spatially resolved single cell analysis suggests an APOE NCF1 associated immunosuppressive niche and its prognostic signature in thyroid cancer.

BACKGROUND: Thyroid carcinoma (TC) presents a rising global incidence, with a subset of cases progressing aggressively despite standard therapies. The...

Machine-learning prediction of 30-day infection-related hospitalization in advanced CKD.

BACKGROUND: Patients with advanced chronic kidney disease (CKD), defined as having an estimated glomerular filtration rate (eGFR) < 45 ml/min/1.73 m²,...