Steroids

Development of a Predictive Model for the Latency Period in Preterm Premature Rupture of Membranes Before 32 Weeks' Gestation.

BACKGROUND: Only 13.7% of corticosteroid treatments occurred within the most effective treatment time window for preterm premature rupture of membranes (PPROM), mainly due to the lack of relevant predictive models. This study aims to analyze the risk factors associated with the duration of the latency period in PPROM to develop a predictive model for the latency period in cases of PPROM before 32 ...

Personalized neoantigen cancer vaccines: Why clinical benefit remains inconsistent.

Personalized cancer vaccines have re-emerged as a promising strategy in precision immunotherapy, driven by advances in tumor sequencing, neoantigen identification, and vaccine delivery platforms. Early-phase clinical trials have consistently demonstrated feasibility, safety, and induction of neoantigen-specific immune responses, with clinical benefit observed in a subset of patients. Despite these...

Bone Magnetic Resonance Imaging: From Conventional Methods to AI-Driven Solutions.

With global population aging and increased life expectancy, bone diseases affect a substantial proportion of individuals worldwide, imposing a signifi...

A multiparameter model (OsteoSC-M3) for early detection and risk stratification of osteoporosis in women: a multicentre cohort study in China.

BACKGROUND: Osteoporosis is a major global health issue, but current early screening tools lack accuracy, and the gold-standard diagnostic method, dua...

Application of machine learning in osteoporosis screening: a narrative review.

Machine learning has the potential to address limitations of traditional osteoporosis screening through advanced data processing and pattern recogniti...

Regulatory B cells and SIVA1-LAG3 immune suppression predict poor prognosis in prostate cancer.

Prostate cancer (PCa) is among the most prevalent malignancies affecting men globally. The immunosuppressive characteristics of the tumor microenviron...

Efferocytosis-related biomarkers and immune infiltration in pancreatic ductal adenocarcinoma based on single-cell sequencing and machine learning: a comprehensive bioinformatics analysis and experimental validation.

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is a highly invasive and lethal malignancy, with its complex tumor microenvironment (TME) severely...

Comment on "Assessing deep learning model performance in osteoporosis screening with lumbar spine radiographs".

Predicting Osteoporosis Risk from Knee Radiographs and Clinical Features through Deep Learning: A Multimodal Approach.

BACKGROUND: Osteoporosis is a prevalent skeletal disease with high morbidity rates in developing countries due to limited access to gold-standard dual...

Targeting cholesterol metabolism: a core regulator of tumor-associated macrophage plasticity and immunotherapy response.

Tumor-associated macrophages (TAMs) are one of the main immunosuppressive components in the tumor microenvironment (TME). Growing evidence indicates t...

Machine learning-based programmed cell death gene signature for prognosis and drug sensitivity in breast cancer.

Breast cancer (BRCA) heterogeneity necessitates robust prognostic biomarkers. Programmed cell death (PCD) serves a key role in tumor progression and t...

Linking brain structure to stress reactivity: cingulate surface area predicts acute cortisol responses.

BACKGROUND: Altered stress responses are closely linked to mental disorders, but the role of brain structure in acute cortisol responses to psychosoci...

NQO1-Mediated Anoikis Resistance and Immune Evasion Define a High-Risk Multi-Omic Subtype for Precision Management of T1 High-Grade Bladder Cancer.

T1 high-grade (T1HG) bladder cancer represents an aggressive subset of non-muscle-invasive bladder cancer (NMIBC) with frequent Bacillus Calmette-Guér...

A palmitoylation-related prognostic risk scoring model and tumor microenvironment characterization in lung adenocarcinoma, using single-cell RNA sequencing data.

BACKGROUND: Lung adenocarcinoma (LUAD) is the predominant pathological subtype of non-small cell lung cancer. Its considerable tumor heterogeneity and...

Integrating Machine Learning into Fracture Liaison Services: Toward precision risk stratification in osteoporosis care: A prospective cohort study.

BACKGROUND: Traditional fracture risk assessment tools have limitations in accurately predicting re-fracture risk. Machine learning (ML) approaches of...

LILRB3 inhibition reverses immunosuppression in glioma: a nanoparticle-based therapeutic strategy.

Glioma is a highly aggressive brain tumor characterized by a profoundly immunosuppressive tumor microenvironment dominated by M2-polarized tumor-assoc...

Apoptotic extracellular vesicles act as master regulators of the bone healing niche.

Apoptotic extracellular vesicles (ApoEVs), natural bilayer nanoparticles released during programmed cell death, have emerged as pivotal regulators and...

Exploratory prediction model for deep vein thrombosis in intensive care patients after anticoagulation therapy: An observational study.

BACKGROUND: Despite low-molecular-weight heparin (LMWH) prophylaxis, the incidence of deep vein thrombosis (DVT) remains high in intensive care unit (...

Deciphering risk factors for severe postherpetic neuralgia in patients with herpes zoster: an interpretable machine learning approach.

INTRODUCTION: Postherpetic neuralgia (PHN) is a common complication of herpes zoster (HZ). This study aimed to use a large real-world electronic medic...

Models Integrating Disease Heterogeneity and MPA Exposure Predict Systemic and Renal Efficacy of Mycophenolate in Pediatric Lupus Nephritis.

OBJECTIVES: This study aimed to develop and validate integrated prediction models for pediatric lupus nephritis (LN) treated with a mycophenolate mofe...