Steroids

The knowledge distillation-assisted multimodal model for osteoporosis screening.

BACKGROUND AND OBJECTIVE: Osteoporosis is characterized by reduced bone mass and deterioration of bo...

A labeled dataset for osteoporosis screening based on electromagnetic attenuation.

Resting-State Functional MRI Reveals Altered Seed-Based Connectivity in Diabetic Osteoporosis Patients.

BACKGROUND: Diabetic osteoporosis (DOP) can cause abnormal brain neural activity, but its mechanism ...

Advances of oncolytic vaccinia viruses armed with interleukin in tumor therapy.

Oncolytic vaccinia viruses armed with interleukins represent a promising frontier in tumor therapy. ...

A multi-faceted discovery strategy identifies functional antibodies binding to cysteine-rich domain 1 of hDKK1 for cancer immunotherapy via Wnt non-canonical pathway.

Wnt signaling is important in embryonic development and tumorigenesis. These biological effects can ...

Predicting Treatment Outcomes in Glioblastoma: A Risk Score Model for TMZ Resistance and Immune Checkpoint Inhibition.

Glioblastoma (GBM) presents significant therapeutic challenges due to its invasive nature and resist...

Uncemented hip arthroplasty and denosumab: increased postoperative dipeptide concentrations and identification of potential new bone turnover biomarkers.

Denosumab is a potent antagonist of RANKL and is widely used to treat severe postmenopausal osteopor...

Multi-Steroid Profiling and Machine Learning Reveal Androgens as Candidate Biomarkers for Endometrial Cancer Diagnosis: A Case-Control Study.

OBJECTIVE: To evaluate the diagnostic and prognostic potential of preoperative serum steroid levels ...

Longitudinal changes in minerals are influenced by immunosuppressive treatment in men with granuloma disease.

PURPOSE: To investigate whether granuloma formation following self-administered cosmetic oil injecti...

Step up to triple therapy versus switch to dual bronchodilator therapy in patients with COPD on an inhaled corticosteroid/long-acting β-agonist: post-hoc analyses of KRONOS.

BACKGROUND: In people with chronic obstructive pulmonary disease (COPD) on inhaled corticosteroid/lo...

Comparison of Machine Learning Algorithms and Bayesian Estimation in Predicting Tacrolimus Concentration in Tunisian Kidney Transplant Patients During the Early Post-Transplant Period.

BACKGROUND AND OBJECTIVE: Model-informed precision dosing (MIPD), based on a Bayesian approach and m...

Branding a New Technological Outlook for Future Orthopaedics.

Orthopedics is undergoing a transformative shift driven by personalized medical technologies that en...

The Role of Computed Tomography and Artificial Intelligence in Evaluating the Comorbidities of Chronic Obstructive Pulmonary Disease: A One-Stop CT Scanning for Lung Cancer Screening.

Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. ...

Deep Learning-enhanced Opportunistic Osteoporosis Screening in Ultralow-Voltage (80 kV) Chest CT: A Preliminary Study.

RATIONALE AND OBJECTIVES: To explore the feasibility of deep learning (DL)-enhanced, fully automated...

M3S-GRPred: a novel ensemble learning approach for the interpretable prediction of glucocorticoid receptor antagonists using a multi-step stacking strategy.

Accelerating drug discovery for glucocorticoid receptor (GR)-related disorders, including innovative...

Using artificial intelligence-based software for an unbiased discrimination of immune cell subtypes in the fracture hematoma and bone marrow of non-osteoporotic and osteoporotic mice.

It is well established that the early inflammatory response following fracture is essential for init...

Advancing Cardiovascular, Kidney, and Metabolic Medicine: A Narrative Review of Insights and Innovations for the Future.

Cardiovascular, kidney and metabolic (CKM) conditions are interrelated, significantly contributing t...

Beyond immunosuppression: decoding systemic immune dysregulation in ICU-acquired pneumonia.

Use of a priority lane to increase voluntary visits to a milking robot in dairy cows.

Voluntary visits to the milking robot are the basis of automatic milking system functionality. There...

Automated opportunistic screening for osteoporosis using deep learning-based automatic segmentation and radiomics on proximal femur images from low-dose abdominal CT.

RATIONALE AND OBJECTIVES: To establish an automated osteoporosis detection model based on low-dose a...

ShenJiaoLingCao decoction ameliorates cyclophosphamide-induced splenic injury and immunosuppression via the inhibition of MEK/ERK signaling pathway activity and modulation of amino acid metabolism.

ETHNOPHARMACOLOGICAL RELEVANCE: ShenJiaoLingCao Decoction (SJLCD) is derived from the classic Chines...