Steroids

UHRF2 related to sumoylation : assessment of its role in immune suppression and therapeutic potential in colorectal cancer.

SUMOylation is a critical post-translational modification of proteins. However, the roles of SUMOylation-related genes in regulating the tumor immune microenvironment and their potential as therapeutic targets in CRC remain unclear. We integrated transcriptomic data from TCGA and GEO to identify 200 SUMOylation-related genes associated with prognosis. Among these, 58 genes exhibiting significant s...

Multi-dimensional dynamic monitoring of gut microbiota-emotion axis and precision exercise intervention in compulsory drug rehabilitation: A 24-week randomized controlled trial.

BACKGROUND/OBJECTIVES: Substance use disorders (SUDs) present a global health challenge with high relapse rates. Emerging evidence implicates gut microbiota dysbiosis in SUD pathophysiology via the gut-brain axis. This 24-week randomized controlled trial investigated whether precision exercise interventions could modulate the gut microbiota-emotion axis to improve psychological outcomes in individ...

CXCL9 as a key feature for deep learning-based immune subtyping and prediction of immune checkpoint blockade response in triple-negative breast cancer.

BACKGROUND: Immune checkpoint blockade (ICB) therapy has provided a promising treatment option for patients with triple-negative breast cancer (TNBC)....

Random forest-based QSAR and molecular dynamics insights into steroidal pregnanes as 11β-hydroxysteroid dehydrogenase type 1 modulators for type 2 diabetes.

The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a validated therapeutic target for type 2 diabetes mellitus due to its role in local ...

Deep Learning-Based Prediction of Trabecular Bone Mineral Density From Lumbar CT: A Superior Alternative to DEXA in Hyperostosis.

Study DesignRetrospective Cohort Study.ObjectivesThis study explores using deep learning to predict lumbar spine bone mineral density (BMD) from CT im...

Phosphoenolpyruvate carboxykinase 2 as a prognostic biomarker: expression and clinical significance in Group 3 and Group 4 medulloblastoma.

PURPOSE: Despite Phosphoenolpyruvate carboxykinase 2 (PCK2) has attracted growing attention as a potential biomarker in cancer research, its role in m...

PAST, PRESENT and FUTURE OF LUPUS NEPHRITIS.

INTRODUCTION: Our objective is to delineate the evolution of lupus nephritis (LN) histological classifications and management, from their origins to t...

Machine learning derived proliferating T cell-related signature: a novel biomarker for prognosis and treatment efficacy in clear cell renal cell carcinoma.

BACKGROUND: Clear cell renal cell carcinoma (ccRCC) exhibits profound molecular heterogeneity, and reliable biomarkers for predicting clinical outcome...

Diagnostic accuracy of deep learning vs. human raters for detecting osteoporotic vertebral compression fractures in routine CT scans.

OBJECTIVES: Vertebral fractures are severe complications of osteoporosis but are frequently missed on computed tomography (CT). Differentiating true f...

Two -stage contrastive learning framework for vertebral compression fracture screening in frontal chest X-ray.

Vertebral Compression Fractures (VCFs) are early signs of osteoporosis and the most common type of osteoporotic fracture. In clinical practice, the pi...

Machine learning and metabolic signatures of drowning: A pathway to uncovering cause of death in aquatic environments.

The postmortem diagnosis of drowning is challenging due to the nonspecific and transient nature of classical autopsy findings. This study aimed to inv...

Multicentre development and validation of a risk model integrating immunotherapy and coagulation biomarkers for thrombosis in autoimmune neurological disorders.

PURPOSE: Patients with Autoimmune Neurological Disorders (ANDs) require routine immunomodulatory therapy, which inherently increases thrombosis risk. ...

Emerging trends and converging evidence in tumor evolution: A comprehensive review.

BACKGROUND: Tumor evolution is a spatiotemporal dynamic process orchestrated by the interplay of genetic mutations, epigenetic reprogramming, and bidi...

Single-cell transcriptomic analysis and machine learning identify ATAD3A as a key gene that stabilizes mitochondrial-endoplasmic reticulum membranes, promoting bladder cancer progression.

BACKGROUND: Mitochondria-associated endoplasmic reticulum membranes (MAM) play a critical regulatory role in cancer, yet their function in bladder can...

Outer Retinal Erosion and Outer Retinal Pinching at the Origin of Subretinal Fluid in Central Serous Chorioretinopathy.

PURPOSE: To characterize early outer retinal changes at the site of origin of subretinal fluid (SRF) in central serous chorioretinopathy (CSCR). To in...

NPHS2 Revisited Through 208 Cases and Podocin Complex Modeling.

INTRODUCTION: Steroid-resistant nephrotic syndrome (SRNS) is the leading cause of chronic glomerular disease in individuals under 25 years of age. Bia...

Bulk and single-cell transcriptomics for identification of potential diagnostic biomarkers associated with pulmonary arterial hypertension and integrated stress response and experimental validation.

BACKGROUND: Pulmonary arterial hypertension (PAH) is a lethal vascular disorder characterized by irreversible remodeling of the pulmonary arteries, bu...

Advancements in ex vivo bone biomechanics: multimodal technologies and their integration with artificial intelligence.

Bone biomechanics is essential for understanding how bone structure, composition, and mechanical function interact in healthy and diseased states. Con...

Contemporary Management of Radiation Necrosis: Insights and Avenues.

Radiation necrosis (RN) remains a challenging complication of upfront radiation therapy for both brain metastases and primary tumors. Despite developm...

Serum metabolomic signatures of relapse recovery in early multiple sclerosis.

BACKGROUND: Relapses in relapsing-remitting multiple sclerosis (RRMS) are acute neuroinflammatory events that shape long-term disease trajectory. Yet,...